|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatitis B-specific T helper cell responses in uninfected infants born to HBsAg^(+)/HBeAg^(-) mothers显示文摘Vertically transmitted hepatitis B virus(HBV)usually causes chronic infection.While combined active–passive immunoprophylaxis in neonates of hepatitis B surface antigen-positive(HBsAg1)mothers at birth prevents vertical transmission,it is not yet clear whether neonates encounter the virus or its products in the absence of hepatitis B e antigen(HBeAg).This study was undertaken to investigate HBV antigen-specific T-cell responses in vaccinated neonates of HBsAg1/HBeAg2 mothers.Blood was collected from 46 HBsAg1 mothers and their neonates(subjects)as well as 24 age-matched controls.All neonates of HBsAg1 mothers received appropriate immunoprophylaxis,and HBsAg and hepatitis B surface antibody(anti-HBs)antibody titers were determined after completion of the vaccination course.Peripheral blood mononuclear cells(PBMCs)from infants at birth,1 and 6 months of age were stimulated with recombinant HBsAg,hepatitis B core antigen(HBcAg)and mitogen,and interferon(IFN)-c concentrations were determined by ELISA.HBsAg-induced production of IL-2,IL-5,IL-6 and IL-10 was assessed using a cytometric bead array kit on cells from 6-month-old neonates post-vaccination.All neonates were HBsAg2 and responded to vaccination.Increased IFN-c production following HBcAg stimulation was seen in 30.4%of neonates born to HBsAg1/HBeAg2 mothers.Subjects demonstrated significantly higher IL-2 production post-HBsAg stimulation,whereas IL-5,IL-6 and IL-10 cytokine responses were not significantly different.Almost one-third of uninfected neonates developed viral antigen-induced IFN-c production,suggesting that they had been exposed to virions or viral derivatives.This encounter,however,did not impair their T-cell responses to vaccination. | Lemonica Koumbi Antonio Bertoletti Vassiliki Anastasiadou Maria Machaira Winnie Goh Nikolaos G Papadopoulos Dimitris A Kafetzis Vassiliki Papaevangelou | 2010 | Cellular & Molecular Immunology2010，7，6： | 4 |
| 2 | Control or persistence of hepatitis B virus: the critical role of initial host-virus interactions显示文摘 | Webster G J Bertoletti A | 2002 | Immunol Cell Biol2002，80，1： | 2 |
| 3 | Underwhelming the immune response: effect of slow virus growth on CD8+-T-lymphocyte responses显示文摘 | Bocharov G Ludewig B Bertoletti A | 2004 | J Virol2004，78，5： | 1 |
| 4 | Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B显示文摘 | Penna A Del Prete G Cavalli A Bertoletti A D'Elios MM Sorrentino R | | Hepatology0，，： | 1 |
| 5 | Identification of a potential proinflammatory genetic profile influencing carotid plaque vulnerability显示文摘 | Biscetti F Straface G Bertoletti G | 2015 | J Vasc Surg2015，61，2： | 1 |
| 6 | Giant osteoid osteoma of ethmoid sinus: role of functional endoscopic sinus surgery 显示文摘 | Bertoletti F Capolunghi B Bertolini G | 2004 | Acta Otorhinolaryngol Ital2004，24，： | 1 |
| 7 | Characterization of hepatitis B virus(HBV)-specific T-cell dysfunction in chronic HBV infection显示文摘 | Boni C Fisicaro P Valdatta C Amadei B Di Vincenzo P Giuberti T Laccabue D Zerbini A Cavalli A Missale G Bertoletti A Ferrari C | 2007 | J Virol2007，81，8： | 1 |
| 8 | Under- whelming the immune response= effect of slow virus growth on CD81 -T - lymphocyte responses 显示文摘 | BOCHAROV G LUDEWIG B BERTOLETTI A | 2004 | J Virol2004，78，5： | 1 |
| 9 | Quantity and quality of virus-specificCD8 cell response:relevance to the design of a therapeutic vaccine for chronic HBV infection显示文摘 | Webster G Bertoletti A | 2001 | Mol Immunol2001，38，： | 1 |
| 10 | Prognostic value of the Ge- neva prediction rule in patients in whom pulmonary embolism is ruled out 显示文摘 | Bertoletti L Le Gal G Aujesky D | 2011 | J Intern Med2011，269，4： | 1 |
| 11 | Control or persistence of hepatitis B virus: The critical role of initial host-virus interactions显示文摘 | Webster G J Bertoletti A | 2002 | Im- munol Cell Biol2002，80，： | 1 |
| 12 | Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen显示文摘 | Penna AF Chisari A Bertoletti G | 1991 | J Exp Med1991，174，： | 1 |
| 13 | Underwhelming the immune response:effect of slow virus growth on CD8+ -T-lymphocytes response显示文摘 | Bocharov G Ludewig B Bertoletti A | | Journal of Virology0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员