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| 1 | Hepatitis B-specific T helper cell responses in uninfected infants born to HBsAg^(+)/HBeAg^(-) mothers显示文摘Vertically transmitted hepatitis B virus(HBV)usually causes chronic infection.While combined active–passive immunoprophylaxis in neonates of hepatitis B surface antigen-positive(HBsAg1)mothers at birth prevents vertical transmission,it is not yet clear whether neonates encounter the virus or its products in the absence of hepatitis B e antigen(HBeAg).This study was undertaken to investigate HBV antigen-specific T-cell responses in vaccinated neonates of HBsAg1/HBeAg2 mothers.Blood was collected from 46 HBsAg1 mothers and their neonates(subjects)as well as 24 age-matched controls.All neonates of HBsAg1 mothers received appropriate immunoprophylaxis,and HBsAg and hepatitis B surface antibody(anti-HBs)antibody titers were determined after completion of the vaccination course.Peripheral blood mononuclear cells(PBMCs)from infants at birth,1 and 6 months of age were stimulated with recombinant HBsAg,hepatitis B core antigen(HBcAg)and mitogen,and interferon(IFN)-c concentrations were determined by ELISA.HBsAg-induced production of IL-2,IL-5,IL-6 and IL-10 was assessed using a cytometric bead array kit on cells from 6-month-old neonates post-vaccination.All neonates were HBsAg2 and responded to vaccination.Increased IFN-c production following HBcAg stimulation was seen in 30.4%of neonates born to HBsAg1/HBeAg2 mothers.Subjects demonstrated significantly higher IL-2 production post-HBsAg stimulation,whereas IL-5,IL-6 and IL-10 cytokine responses were not significantly different.Almost one-third of uninfected neonates developed viral antigen-induced IFN-c production,suggesting that they had been exposed to virions or viral derivatives.This encounter,however,did not impair their T-cell responses to vaccination. | Lemonica Koumbi Antonio Bertoletti Vassiliki Anastasiadou Maria Machaira Winnie Goh Nikolaos G Papadopoulos Dimitris A Kafetzis Vassiliki Papaevangelou | 2010 | Cellular & Molecular Immunology2010，7，6： | 4 |
| 2 | Different cytokine profiles of intraphepatic T cells in chronic hepatitis B and hepatitis C virus infections显示文摘 | Bertoletti A D'Elios MM Boni C | | 0，，： | 2 |
| 3 | Control or persistence of hepatitis B virus: the critical role of initial host-virus interactions显示文摘 | Webster G J Bertoletti A | 2002 | Immunol Cell Biol2002，80，1： | 2 |
| 4 | Role of hepatitis B virus specific cytotoxie T cells in liver damage and viral control显示文摘 | Bertoletti A MainiM Williams R | 2003 | J Antivial Research2003，60，： | 1 |
| 5 | The immune response during hepatitis B virus infection 显示文摘 | Bertoletti A Gehring AJ | 2006 | J Gen Viro12006，87，6： | 1 |
| 6 | Protection or damage : a dual role for the virus specific cytotoxin T lymphocyte response in hepatitis B and C infection? 显示文摘 | Bertoletti A Maini MK | 2000 | Curr Opin Microbiol2000，3，4： | 1 |
| 7 | Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B显示文摘 | Boni C Bertoletti A Penna A | | 0，，： | 1 |
| 8 | Kinetics of the immune response during HBV and HCV infection 显示文摘 | Bertoletti A Ferrari C | 2003 | Hepatology2003，38，： | 1 |
| 9 | Control or persistence of hepatitis B virus: The critical role of initial host-virus interactions显示文摘 | Webster GJM Bertoletti A | 2002 | Immunol Cell Biology2002，80，： | 1 |
| 10 | Natural variants of cytotoxic epitopes are T-cell receptor antaganists for antiviral cytotoxic T cell显示文摘 | Bertoletti A Sette A Chisari FV | 1994 | Nature1994，369，6479： | 1 |
| 11 | Innate and adaptive immune respon- ses in chronic hepatitis B virus infections,, towards restora- tion of immune control of viral infection显示文摘 | Bertoletti A Ferrari C | 2011 | Gut2011，，： | 1 |
| 12 | Cancer immunotherapy: targeting the difference显示文摘 | Koh S Bertoletti A | 2014 | J Hepatol2014，61，5： | 1 |
| 13 | Role of hepatitis B virus specific cytotoxic T cells in liver damage and viral control显示文摘 | Bertoletti A Maini M Willians R | 2003 | Antiviral Research2003，60，： | 1 |
| 14 | Underwhelming the immune response: effect of slow virus growth on CD8+-T-lymphocyte responses显示文摘 | Bocharov G Ludewig B Bertoletti A | 2004 | J Virol2004，78，5： | 1 |
| 15 | Protection or damage: a dual role for the virus-specific cytotoxic T lymphocyte response in hepatitis B and C virus显示文摘 | Bertoletti A Maini MK | 2000 | Curr Opin Immunol2000，12，4： | 1 |
| 16 | Cytotoxic T lymphocytes recognize an HLA-A2 restricted epitope within the hepatitis B virus nucleocapsid antigen显示文摘 | Penna A Chisari FV Bertoletti A | 1991 | J Exp Med1991，174，6： | 1 |
| 17 | Immune therapeutic strategies in chronic hepatitis B virus infection:virus or inflammation control显示文摘 | Bertoletti A Gehring A J | 2013 | PLoS pathogens2013，9，10： | 1 |
| 18 | Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid Protein显示文摘 | Bertoletti A Chisari FV Penna A | 1993 | J Virol1993，67，： | 1 |
| 19 | Computer-aided detection (CAD) in lung cancer screening at chest MDCT:ROC analysis of CAD versus radiologist performance显示文摘 | Fraioli F Bertoletti L Napoli A | 2007 | J Thorac Imaging2007，22，： | 1 |
| 20 | Role of hepatitis B virus specific cytotoxic T cells in liver damage and viral control 显示文摘 | Bertoletti A Maini M Williams R | 2003 | J Antivial Research2003，60，： | 1 |
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