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| 1 | Chronic liver failure-consortium acute-on-chronic liver failure and acute decompensation scores predict mortality in Brazilian cirrhotic patients显示文摘AIM To validate prognostic scores for acute decompensation of cirrhosis and acute-on-chronic liver failure in Brazilian patients.METHODS This is a prospective cohort study designed to assess the prognostic performance of the chronic liver failure-consortium(CLIF-C) acute decompensation score(CLIF-C AD) and CLIF-C acute-on-chronic liver failure score(CLIF-C ACLF),regarding 28-d and 90-d mortality,as well as to compare them to other prognostic models,such as Model for End-Stage Liver Disease(MELD),MELD Sodium(MELD-Na),ChildPugh(CP) score,and the CLIF-C Organ Failure score(CLIF-C OF). All participants were adults with acute decompensation of cirrhosis admitted to the Emergency Department of a tertiary hospital in southern Brazil. Prognostic performances were evaluated by means of the receiver operating characteristic(ROC) curves,area under the curves(AUC) and 95%CI.RESULTS One hundred and thirteen cirrhotic patients were included. At admission,18 patients had acute-onchronic liver failure(ACLF) and 95 individuals had acute decompensation(AD) without ACLF,of which 24 eventually developed ACLF during the course of hospitalization(AD evolving to ACLF group). The AD group had significantly lower 28-d(9.0%) and 90-d(18.3%) mortality as compared to the AD evolving to ACLF group and to the ACLF group(both P < 0.001). On the other hand,28-d and 90-d mortalities were not significantly different between AD evolving to ACLF group and ACLF group(P = 0.542 and P = 0.708,respectively). Among patients with ACLF,at 28 d from the diagnosis,CLIF-C ACLF was the only score able to predict mortality significantly better than the reference line,with an AUC(95%CI) of 0.71(95%CI: 0.54-0.88,P = 0.021). Among patients with AD,all prognostic scores performed significantly better than the reference line regarding 28-d mortality,presenting with similar AUCs: CLIF-C AD score 0.75(95%CI: 0.63-0.88),CP score 0.72(95%CI: 0.59-0.85),MELD score 0.75(95%CI: 0.61-0.90),MELD-Na score 0.76(95%CI: 0.61-0.90),and CLIF-C OF score 0.74(95%CI: 0.60-0.88). The same occurred concerning AUCs for 90-d mortality: CLIF-C AD score 0.70(95%CI: 0.57-0.82),CP score 0.73(95%CI: 0.62-0.84),MELD score 0.71(95%CI: 0.59-0.83),MELD-Na score 0.73(95%CI: 0.62-0.84),and CLIF-C OF score 0.65(95%CI: 0.52-0.78).CONCLUSION This study demonstrated that CLIF-C ACLF is the best available score for the prediction of 28-d mortality among patients with ACLF. CLIF-C AD score is also useful for the prediction of mortality among cirrhotic patients with AD not fulfilling diagnostic criteria for ACLF,but it was not superior to other well-established prognostic scores. | Rafael Veiga Picon Franciele Sabadin Bertol Cristiane Valle Tovo Angelo Zambam de Mattos | 2017 | World Journal of Gastroenterology2017，23，28： | 4 |
| 2 | Role of micronutrients in staging of nonalcoholic fatty liver disease:A retrospective cross-sectional study显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD) presents high incidence throughout the world and has been progressively increasing in prevalence. This disease has a heterogeneous natural history, including simple steatosis, nonalcoholic steatohepatitis(NASH), and cirrhosis. The factors that determine its evolution to more severe forms of the disease are still poorly understood, and micronutrients with antioxidant potential may be involved in the pathophysiology of the disease.AIM To evaluate the relationship between serum levels of micronutrients and the severity of NAFLD.METHODS A retrospective, observational and cross-sectional study was conducted. This study included all patients undergoing bariatric surgery who experienced liver biopsy during the procedure, and had serum levels of micronutrients(vitamin D,vitamin B12, zinc, iron, and magnesium), which was assessed in a preoperative evaluation conducted at a reference center in southern Brazil.RESULTS A total of 614 patients were analyzed, of which 93% had steatosis, 70.7% had NASH, and 49.3% had some degree of fibrosis. Serum levels of vitamin D were negatively correlated with the severity of steatosis and NASH, and serum levels of vitamin B12 were positively correlated with the severity of steatosis and fibrosis. The other micronutrients showed no association with NAFLD staging.CONCLUSION Serum levels of vitamin D are inversely related to the severity of steatosis and NASH, and serum levels of vitamin B12 are higher in more advanced stages of simple steatosis and liver fibrosis. Serum levels of zinc, iron, and magnesium were not associated with NAFLD severity. | Franciele Sabadin Bertol Bruna Araujo Brunno Brochado Jorge Natalino Rinaldi Luiz Alberto De Carli Cristiane Valle Tovo | 2020 | World Journal of Gastrointestinal Surgery2020，12，6： | 2 |
| 3 | Multiple sclerosis as a cause of partial complex epilepsy显示文摘 | Bertol V Gros MB Ara JR | 1997 | Rev Neurol1997，25，： | 1 |
| 4 | Phosphorus, potassium and organic carbon concentrations in runoff water and sediments under different soil tillage systems during soybean growth显示文摘 | I. Bertol F.L. Engel A.L. Mafra O.J. Bertol S.R. Ritter | 2006 | Soil & Tillage Research2006，，1： | 1 |
| 5 | Electrochemical affinity biosensors for detection of mycotoxins: A review显示文摘 | Juan C. Vidal Laura Bonel Alba Ezquerra Susana Hernández Juan R. Bertolín Carlota Cubel Juan R. Castillo | 2013 | Biosensors and Bioelectronics2013，，： | 1 |
| 6 | Effect of vitamin E, low dose irradiation, and display time on the quality of pork显示文摘 | Ohene-Adjei S Bertol T Hyun Y | 2004 | Meat Science2004，68，1： | 1 |
| 7 | Phosphorus losses in water and sediments in runoff of the water erosion in oat and vetch crops seed in contour and downhill 显示文摘 | BARBOSA F T BERTOL I LUCIANO R V | 2009 | Soil & Tillage Research2009，106，： | 1 |
| 8 | Phosphorus, potassium and organic carbon concentrations in runoff water and sediments under different soil tillage systems during soybean growth显示文摘 | Bertol I Engel F L Malta A L | 2007 | Soil & Tillage Research2007，94，： | 1 |
| 9 | Critical slopelength for water erosion for three crop residue types andrates in two sowing directions in no-till显示文摘 | Barbosa F T Bertol I Werner R D | 2012 | RevistaBrasileira DE Ciencia Do Solo2012，36，4： | 1 |
| 10 | Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope 显示文摘 | BERTOLEITI A COSTANZO A CHISARI FV | 1994 | J Exp Med1994，180，3： | 1 |
| 11 | Subsurface oxygen显示文摘 | Christopher J Bertole Charles A Mins | 1999 | J Catal1999，184，1： | 1 |
| 12 | Phosphorus losses in water and sediments in runoff of the water erosion in oat and vetch crops seed in contour and downhill 显示文摘 | Barbosa F T Bertol I Luciano R V | 2009 | Soil and Tillage Research2009，106，1： | 1 |
| 13 | Medi- cal design: Direct metal laser sintering o{ Ti-6A1-4V显示文摘 | Bertol L S Jfinior W K Pinto da Silva Fabio | 2010 | Mater Des2010，31，8： | 1 |
| 14 | Lactobacillus plantarum strains isolated from naturally fermented sausages and their technological properties for application as starter cultures显示文摘 | SAWITZKI M C FIORENTINI ? M BERTOL T M | 2009 | Food Science and Technology2009，29，2： | 1 |
| 15 | Effect of vitamin E, low dose irradiation,and display time on the quality of pork显示文摘 | Ohene Adjei S Bertol T | 2004 | Meat Science2004，68，： | 1 |
| 16 | Trajectory tracking of a nonholonomic mobile robot with kinematic disturbances : a variable structure control design 显示文摘 | Martins N A Elyoussef E S Bertol D W | 2011 | Latin America Transactions2011，9，3： | 1 |
| 17 | Effect of surgical fit on integration of cancel ous bone and implant cortical bone shear strength for a porous titanium显示文摘 | Bertol o N Matsubara M Shinoda T | | 0，，07： | 1 |
| 18 | Different cytokine proftles of in trahepatic T cell in chronic hepatitis B and hepatitis C virus infections显示文摘 | Bertoleiti A Delios M M Boni C | 1997 | Gastroenterology1997，112，1： | 1 |
| 19 | Medical design: direct metal laser sintering of Ti-6A1-4V显示文摘 | Bertol LS J6nior WK Silva FP | 2010 | Mater Des2010，31，8： | 1 |
| 20 | Epicardial fat:definition,measurements and systematic review of main outcomes显示文摘 | Bertaso AG Bertol D Duncan BB | 2013 | Arq Bras Cardiol2013，101，1： | 1 |
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