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| 1 | Cilostazol for secondary stroke prevention:systematic review and meta-analysis显示文摘Background Stroke is one of the leading causes of death worldwide.Cilostazol,an antiplatelet and phosphodiesterase 3 inhibitor,has not been clearly established for ischaemic stroke use.We aim to determine the efficacy and safety of cilostazol for secondary stroke prevention.Methods MEDLINE,EMBASE,Cochrane Library,Web of Science and ClinicalTrials.gov were searched from inception to 25 September 2020,for randomised trials comparing the efficacy and safety of cilostazol monotherapy or dual therapy with another antiplatelet regimen or placebo,in patients with ischaemic stroke.Version 2 of the Cochrane risk-of-bias tool for randomised trials(RoB 2)was used to assess study quality.This meta-analysis was reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)statement.Results Eighteen randomised trials comprising 11429 participants were included in this meta-analysis.Most trials possessed low risk of bias and were of low heterogeneity.Cilostazol significantly reduced the rate of ischaemic stroke recurrence(risk ratio,RR=0.69,95%CI 0.58 to 0.81),any stroke recurrence(RR=0.64,95%CI 0.54 to 0.74)and major adverse cardiovascular events(RR=0.67,95%CI 0.56 to 0.81).Cilostazol did not significantly decrease mortality(RR=0.90,95%CI 0.64 to 1.25)or increase the rate of good functional outcome(Modified Rankin Scale score of 0–1;RR=1.07,95%CI 0.95 to 1.19).Cilostazol demonstrated favourable safety profile,significantly reducing the risk of intracranial haemorrhage(RR=0.46,95%CI 0.31 to 0.68)and major haemorrhagic events(RR=0.49,95%CI 0.34 to 0.70).Conclusions Cilostazol demonstrated superior efficacy and safety profiles compared with traditional antiplatelet regimens such as aspirin and clopidogrel for secondary stroke prevention but does not appear to affect functional outcomes.Future randomised trials can be conducted outside East Asia,or compare cilostazol with a wider range of antiplatelet agents. | Choon Han Tan Andrew GR Wu Ching-Hui Sia Aloysius ST Leow Bernard PL Chan Vijay Kumar Sharma Leonard LL Yeo Benjamin YQ Tan | 2021 | Stroke & Vascular Neurology2021，6，3： | 2 |
| 2 | Primary osseous tumors of the spine显示文摘 | Bernard SA Brian PL Flemming DJ | 2013 | Semin Musculoskelet Radiol2013，17，2： | 1 |
| 3 | Reproducibility of the time to peak torque and the joint angle at pak torque on knee of young sportsmen on the isokinetic dynamometer 显示文摘 | Bernard PL Amato M Degache F | 2012 | Ann Phys Rehabil Med2012，55，4： | 1 |
| 4 | CD99 acts as an Oncosuppressor in osteosarcoma 显示文摘 | Manara MC Bernard G Lollini PL | 2006 | Mol Biol Cell2006，17，4： | 1 |
| 5 | Reproducibility of isokinetic shoulder testing显示文摘 | Codine P Bernard PL Sablayrolles P | | 0，，： | 1 |
| 6 | Influence of sports discipline on shoulder cuff balance 显示文摘 | Codine P Bernard PL Poeholle M | 1997 | Med Sci Exere1997，29，11： | 1 |
| 7 | CD99 Acts as an Oncosuppressor in Osteosarcoma显示文摘 | Manara MC Bernard G Lollini PL | 2006 | Mol Bio Cell2006，17，4： | 1 |
| 8 | CD99 acts as an oncosuppressor in osteosarcoma 显示文摘 | Manam MC Bernard G Lollini PL | 2006 | Mol Biol Cell2006，17，4： | 1 |
| 9 | Influence of sports discipline on shoulder roator cuff balance显示文摘 | Codine P Bernard PL | 1997 | Med sci Sport Exerc1997，11，： | 1 |
| 10 | Diffusion-negative MRI in acute ischemic stroke:a case report显示文摘 | Rahul R Vijay KS Bernard PL | 2008 | Cases J2008，1，1： | 1 |
| 11 | Influence of lesion level on the eardioventilatory adaptations in paraplegic wheelchair athletes during muscular exercise显示文摘 | Bernard PL Mercier J Varray A | 2000 | Spinal Cord2000，38，： | 1 |
| 12 | CD99 acts as an oncosuppressor in osteosarcoma 显示文摘 | Manara MC Bernard G Lollini PL | 2006 | Mol Biol Cell2006，17，4： | 1 |
| 13 | Influence of soprts discipline on shoulder rotator cuff balance显示文摘 | Codine P Bernard PL Pocholle M Benaim Cbrun V | 1997 | Med Sci Sports Exerc1997，27，： | 1 |
| 14 | Reproducibility of the time to peak torque and the joint angle at peak torque on knee of young sportsmen on the isokinetic dyna- mometer显示文摘 | Bernard PL Amato M DegacheF | 2012 | Annals of physical and rehabilitation medi cine2012，55，4： | 1 |
| 15 | Polyethylene wear after total elbow arthroplasty显示文摘 | Brian PL Robert AA Bernard FM | 2005 | J Bone Joint Surg Am2005，87，： | 1 |
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