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| 1 | Andrographolide Loaded in Micro-and Nano-Formulations: Improved Bioavailability, Target-Tissue Distribution, and Efficacy of the “King of Bitters”显示文摘Andrographolide (AG) is the characteristic constituent of Andrographis paniculata, of the Acanthaceae family. This plant is a well-known Asian medicinal plant that is widely used in India, China, and Thailand. A monograph of Herba Andrographidis (Chuanxinlian) is included in the Chinese Pharmacopoeia, which reports that this decoction can “remove heat, counteract toxicity, and reduce swellings.” The numerous potential activities of AG range from anti-inflammatory to anti-diabetic action, from neuroprotection to antitumor activity, and from hepatoprotective to anti-obesity properties. However, AG has low bioavailability and poor water solubility, which can limit its distribution and accumulation in the body after administration. In addition, AG is not stable in gastrointestinal alkaline and acidic environments, and has been reported to have a very short half-life. Among the diverse strategies that have been adopted to increase AG water solubility and permeability, the technological approach is the most useful way to develop appropriate delivery systems. This review reports on published studies related to microparticles (MPs) and nanoparticles (NPs) loaded with AG. MPs based on polylactic-glycolic acid (PLGA), alginic acid, and glucan derivatives have been developed for parenteral oral and pulmonary administration, respectively. NPs include vesicles (both liposomes and niosomes);polymeric NPs (based on polyvinyl alcohol, polymerized phenylboronic acid, PLGA, human serum albumin, poly ethylcyanoacrylate, and polymeric micelles);solid lipid NPs;microemulsions and nanoemulsions;gold NPs;nanocrystals;and nanosuspensions. Improved bioavailability, target-tissue distribution, and efficacy of AG loaded in the described drug delivery systems have been reported. | Marta Casamonti Laura Risaliti Giulia Vanti Vieri Piazzini Maria Camilla Bergonzi Anna Rita Bilia | 2019 | Engineering2019，5，1： | 5 |
| 2 | Role of sonoelastography in non-palpable breast lesions显示文摘 | Gianfranco Scaperrotta Claudio Ferranti Claudia Costa Luigi Mariani Monica Marchesini Laura Suman Cristina Folini Silvana Bergonzi | 2008 | European Radiology2008，，11： | 1 |
| 3 | Effects of two target- controlled concentrations( 1 and 3 ng/mL) of remifentanil on MAC (BAR) of sevoflurane 显示文摘 | Albertin A Casati A Bergonzi P | 2004 | Anesthesiology2004，100，2： | 1 |
| 4 | Oxcarbazepine reduces seizure frequency in a high proportion of patients with both newly diagnosed and refractory partial seizures in clinical practice显示文摘 | Pauletto G Bergonzi P Triveneto Epilepsy Study Group | 2006 | Seizure2006，15，3： | 1 |
| 5 | Simultaneous analysis of artemisinin and flavonoids of several extracts of Ar- temisia annua L obtained from a commercial sample and a selected cuhivar显示文摘 | Bilia A R de Malgalhaes P M Bergonzi M C | 2006 | Phytomedicine2006，13，7： | 1 |
| 6 | Effects of two target controlled concentrations (1 and 3ng/ml) of remifentanil on MAC (BAR) of sevoflurane显示文摘 | Albertin A Casati A Bergonzi P | 2004 | Anesthesiology2004，100，： | 1 |
| 7 | Effects of two target-controlled concentrations( 1 and 3 ng/ml ) of remifentanil on MAC (BAR) of sevoflurane显示文摘 | Albertin A Casati A Bergonzi P | 2004 | Anesthesiology2004，100，2： | 1 |
| 8 | The effect of addingnitrous oxide on MAC of sevoflurane combined with two target-controlled concentrations of remifentanil in women显示文摘 | Albertin A Casati A Bergonzi PC | 2005 | European Journal of Anaesthesiology2005，22，6： | 1 |
| 9 | Effects of two target controlled concertrations(1 and 3 ng/mL)of remifentanil on MAC (BAR) of sevoflurane显示文摘 | Albertin A Casati A Bergonzi P | 2004 | Anesthesiology2004，100，25： | 1 |
| 10 | Aa TFL1 con- fers an age dependent response to vernalization in perennial Ara- bis alpine 显示文摘 | WANG R ALBANI M C VINCENT C BERGONZI S LUAN M BAI Y KIEFER C CASTILLO R COUPLAND G | 2011 | The Plant Cell2011，23，4： | 1 |
| 11 | 显示文摘 | BILIA A R BERGONZI M C VINCIERI F F | 2002 | J Pharm Sci2002，91，： | 1 |
| 12 | Effects of Two controlled Concentrations (1 and 3 ng/ml) of Remifentanil on MAC(BAR) of Sevoflurane显示文摘 | Albertin A Casati A Bergonzi P | 2004 | Anesthesiology2004，100，： | 1 |
| 13 | Characterization of commercial kava-kava herbal drug and herbal drug preparations by means of nuclear magnetic resonance spectroscopy显示文摘 | Bilia AR Bergonzi MC Lazari D | 2002 | Journal of agricultural and food chemistry2002，50，18： | 1 |
| 14 | Oxcarbazepine reduces seizure frequency in a high proportion of patients with both newly diagnosed and refractory partial seizures in clinical practice显示文摘 | Pauletto G Bergonzi P | 2006 | Seizure2006，15，： | 1 |
| 15 | Effects of two tar- get-controlled concentrations ( 1 and 3 ng/mL ) of remifentanil on Mac(BAR) of sevoflurane显示文摘 | Albertin A Casati A Bergonzi P | 2004 | Anesthesi-ology2004，100，25： | 1 |
| 16 | Validated method for the analysis of goji berry, a rich source of zeaxanthin dipalmitate 显示文摘 | Karioti A Bergonzi MC Vincieri FF | 2014 | J Agric Food Chem2014，62，12： | 1 |
| 17 | Central nervous systern involvement in myasthenia gravis显示文摘 | Bergonzi P Mazza S Mennuni G | 1981 | Ann NY Acad Sci1981，377，： | 1 |
| 18 | The effect of adding nitrous oxide on Mac of sevoflurane combined with two target controlled concentrations of remifentanil in women显示文摘 | Albertin A Casati A Bergonzi PC | 2005 | Eur J Anaesthesiol2005，22，6： | 1 |
| 19 | Dramatic atherosclerotic vascular burden in a patient with familial lecithin - cholesterol acyltransferase (LCAT) deficiency 显示文摘 | Scarpioni R Paties C Bergonzi G | 2008 | Nephrol Dial Transplant2008，23，3： | 1 |
| 20 | Oxcarbazepine reduces seizure frequency in a high proportion ofpatients with both newly diagnosed and refractory partial seizures in clinicalpractice显示文摘 | Pauletto G Bergonzi P | 2006 | Seizure2006，15，3： | 1 |
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