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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | 黑龙江省发现马铃薯晚疫病菌(Phytophthora infestans)A2交配型显示文摘对2005-2012年间采集自黑龙江省哈尔滨、望奎、漠河、塔河、呼玛、加格达奇、嫩江、克山、甘南、鹤岗、肇东、林口12个市县的133个马铃薯晚疫病菌株进行了交配型鉴定。结果表明,采集自2005-2010年间的51个菌株均为A1交配型,未发现A2交配型;采集自2011年的52个菌株中12个为A2交配型,占23.08%;2012年鉴定的30个菌株中9个为A2交配型,占30%。这是自2004年朱杰华报道发现一株A2交配型六年后,黑龙江省首次确认在甘南、哈尔滨、肇东发现马铃薯晚疫病菌A2交配型。 | 郭梅 César Vincent 闵凡祥 吕军 高云飞 杨帅 王晓丹 Rolot Jean-louis | 2015 | 中国马铃薯2015，29，3： | 4 |
| 3 | 金属诱导非晶硅横向晶化形成的多晶硅的生长研究显示文摘详细研究了金属诱导非晶硅横向晶化时间、温度对晶化生长的影响。结果显示 ,晶化生长速度受温度影响较大 ,其最大生长速度在 6 2 5℃附近。在较高的温度下 ,非晶自发成核和晶化 ,从而限制了金属诱导晶体生长速度。镍诱导源的长度和厚度也对晶体生长有影响 。 | 秦明 Yuen C Y Poon Vincent M C 黄庆安 | 2001 | 固体电子学研究与进展2001，21，3： | 4 |
| 4 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 5 | Fretting wear and cracking in sintered metal matrix composites显示文摘 | Martin B Vincent L Wright C S | 2001 | Wear2001，248，1： | 2 |
| 6 | Use of discrete fourier transform in the measurement of frequencies and levels of tones显示文摘 | Rife D C Vincent G A | | 0，，02： | 2 |
| 7 | Myofibroblast:a prognostic marker and target cell in progressive renal disease显示文摘 | Badid C Vincent M Fouque D | 2001 | Renal Fail2001，23，： | 2 |
| 8 | Dendritic cells harbor infectious porcine circovirus type 2 in the absence of apparent cell modulation or replication of the virus显示文摘 | Vincent I E Carrasco C P Herrmann B | 2003 | J Virol2003，77，13： | 1 |
| 9 | A comparision of three different approaches to tourism arrival forecasting显示文摘 | Vincent C | 2003 | Tourism Management2003，24，3： | 1 |
| 10 | Selection of new Kynarbased electrolytes for lithium-ion batteries显示文摘 | Christie A M Christie L Vincent C A | 1998 | J Power Sources1998，74，1： | 1 |
| 11 | α-synucleinLowersp 53-dependent apoptotic response of neuronal cells显示文摘 | Aires da Costa C Paitel E Vincent B | 2002 | J Biological Chemistry2002，277，50： | 1 |
| 12 | Antipernulear factor compared with the so called 'antikeratin' antibodies to human epidermis filaggrin,in the diagnosis of arthritis显示文摘 | Vincent c de Keyser F Masson-Bessiere C | 1999 | Ann Rheum Dis1999，58，1： | 1 |
| 13 | Shorterm hyperglycemia produce- soxdative damage and apoptosis in neurons显示文摘 | Vincent AM Melean LL Backus C | 2005 | FASEB J2005，19，6： | 1 |
| 14 | Sample preparation strategy for the simultaneous determination of macrolide antibiotics in animal feedingstuffs by liquid chroma- tography with electrochemical detection (HPLC-ECD)显示文摘 | Gonzdlez de la Huebra M J Vincent Uvon Hoist C | 2007 | J Pharm Biomed Anal2007，43，5： | 1 |
| 15 | Percutaneous fixation of thoracolumbar fractures : current concepts显示文摘 | Court C Vincent C | 2012 | OrthopTraumatol Surg2012，8，： | 1 |
| 16 | Sepsis in European intensive care units : results of the soap study 显示文摘 | Vincent J L Sakr Y Sprung C L | 2006 | Crit Care Med2006，34，2： | 1 |
| 17 | Neurosurgical outcomes after intracerebral hemorrhage:results of the factor seven for acute hemorrhagic stroke trial(FAST)显示文摘 | Steiner T Vincent C Morris S | 2011 | J Stroke Cerebrovasc Dis2011，20，4： | 1 |
| 18 | Chromium oligopeptide activates insulin receptor tyrosin kinase activity 显示文摘 | Davis C M Vincent J B | 1997 | Biochem1997，36，15： | 1 |
| 19 | Influence of carbide coatings on the oxidation behavior of carbon fibers显示文摘 | Piquero T Vincent H Vincent C | 1995 | Carbon1995，33，1： | 1 |
| 20 | Nonspecific interstitial pneumonia individuali-zation of a clinico- pathologic entity in a series of 12 patients显示文摘 | Vincent C Donsbeck AV Revel D | 1998 | Am J Respir Crit Care Med1998，158，： | 1 |
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