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| 1 | The crystal structure of the non-liganded 14-3-3σ protein: insights into determinants of isoform specific ligand binding and dimerization显示文摘Seven different, but highly conserved 14-3-3 proteins are involved in diverse signaling pathways in human cells. It isunclear how the 14-3-3σ isoform, a transcriptional target of p53, exerts its inhibitory effect on the cell cycle in thepresence of other 14-3-3 isoforms, which are constitutively expressed at high levels. In order to identify structuraldifferences between the 14-3-3 isoforms, we solved the crystal structure of the human 14-3-3σ protein at a resolutionof 2.8 ? and compared it to the known structures of 14-3-3ζ and 14-3-3τ. The global architecture of the 14-3-3σ foldis similar to the previously determined structures of 14-3-3ζ and 14-3-3τ: two 14-3-3σ molecules form a cup-shapeddimer. Significant differences between these 14-3-3 isoforms were detected adjacent to the amphipathic groove, whichmediates the binding to phosphorylated consensus motifs in 14-3-3-ligands. Another specificity determining region islocalized between amino-acids 203 to 215. These differences presumably select for the interaction with specific ligands,which may explain the different biological functions of the respective 14-3-3 isoforms. Furthermore, the two 14-3-3σmolecules forming a dimer differ by the spatial position of the ninth helix, which is shifted to the inside of the ligandinteraction surface, thus indicating adaptability of this part of the molecule. In addition, 5 non-conserved residues arelocated at the interface between two 14-3-3σ proteins forming a dimer and represent candidate determinants of homo-and hetero-dimerization specificity. The structural differences among the 14-3-3 isoforms described here presumablycontribute to isoform-specific interactions and functions. | Anne BENZINGER Grzegorz M. POPOWICZ Joma K. JOY Sudipta MAJUMDAR Tad A. HOLAK Heiko HERMEKING | 2005 | Cell Research2005，15，4： | 6 |
| 2 | 14-3-3 proteins in cell cycle regulation显示文摘 | Heiko Hermeking Anne Benzinger | 2006 | Seminars in Cancer Biology2006，，3： | 1 |
| 3 | Clinical and biomarker changes in dominantly inherited Alzheimer's disease显示文摘 | Bateman R J Xiong C Benzinger TL | 2012 | N Engl J Med2012，367，： | 1 |
| 4 | Clinical and biomarker changes in dominantly inherited Mzheimer' s disease 显示文摘 | Bateman RJ Xiong C Benzinger TL | 2012 | N Engl J Med2012，367，9： | 1 |
| 5 | Lacking prognostic significance of beta 2-microglobulin,MHC class I and class II antigen expression in breast carcinomas显示文摘 | Wintzer H O Benzing M von Kleist S | | 0，，02： | 1 |
| 6 | Postcontrast susceptibility-weighted imaging:a novel techniquefor the detection of arteriovenous shunting in vascular malforma-tions of the brain显示文摘 | Jagadeesan BD Delgado-Almandoz JE Benzinger TL | 2011 | Stroke2011，42，11： | 1 |
| 7 | Assistentenmotivation und -zufriedenheit in der Urologie显示文摘 | T. Enzmann H. Buxel F. Benzing | 2010 | Der Urologe2010，，8： | 1 |
| 8 | The role of imaging in the management of adults with diffuse low grade glioma : A systematic review and evidence-based clinical practice guideline 显示文摘 | Fouke S J Benzinger T Gibson D | 2015 | J Neu- roonco12015，125，3： | 1 |
| 9 | Assessing the role of internships in the career-oriented employment of graduating college students显示文摘 | Callanan G Benzing C | | 0，，02： | 1 |
| 10 | Targeted proteomic analysis of 14-3-3 sigma,a p53 effector commonly silenced in cancer显示文摘 | Benzinger A Muster N Koch H B | 2005 | Mol Cell Proteomics2005，，4： | 1 |
| 11 | Studies on proteinliposome coupling using novel thiol-reactive coupling hpids:influence of spacer length and polarity显示文摘 | Fleiner M Benzinger P Fichert T | 2001 | Bioconjug Chem2001，12，4： | 1 |
| 12 | Chemical vapor infiltration of pyrocarbon:Ⅰ Some kinetics considerations显示文摘 | BENZINGER W H(U)TTINGER K J | 1996 | Carbon1996，34，12： | 1 |
| 13 | Targeted proteomic analysis of 14-3-3 sigma,a p53 effector commonly silenced in cancer显示文摘 | Benzinger A Muster N Koch HB | 2005 | Mol Cell Proteomics2005，4，6： | 1 |
| 14 | Targeted proteomic analysis of 14-3-3 sigma,a p53 effeetor commonly silenced in cancer显示文摘 | Benzinger A Muster N Koch H B | 2005 | Mol Cell Proteomics2005，4，6： | 1 |
| 15 | Using Discriminant Analysis to Predict Financial Distress显示文摘 | Cythia | 2000 | International Advances in Economic Research2000，，6： | 1 |
| 16 | Chemistry and kinetics of chemical vapour deposition of pyrocarbon I: Fundamentals of kinetics and chemical reaction engineering显示文摘 | Benzinger W Becker A Htittinger K J | 1996 | Carbon1996，34，8： | 1 |
| 17 | High temperature ultrafdtration with Kynar poly (vinylidene fluoride) membranes显示文摘 | Benzinger W D Parekh B S Eichelberger J L | 1980 | Sep Sei Technol1980，15，4： | 1 |
| 18 | Improved lifetime measurements of the 3D3/2 and 3D5/2 metastable states of Ca II显示文摘 | F. Arbes M. Benzing T. Gudjons F. Kurth G. Werth | 1994 | Zeitschrift für Physik D Atoms Molecules and Clusters1994，，3： | 1 |
| 19 | Leflunomide Therapy for Polyomavirus-Induced Allograft Nephropathy: Efficient BK Virus Elimination Without Increased Risk of Rejection显示文摘 | S. Teschner P. Gerke M. Geyer J. Wilpert B. Krumme T. Benzing G. Walz | 2009 | Transplantation Proceedings2009，，6： | 1 |
| 20 | Targeted Proteomic Analysis of 14-3-3 Signa, A P53 Effector Commonly Silenced in Cancer显示文摘 | Benzinger A Muster N Koch H B | 2005 | Mol Cell Proteomics2005，4，6： | 1 |
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