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| 1 | Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria显示文摘AIM: To investigate the correlation between in vitro and in vivo immunomodulation potential of the probiotic strain and its ability to prevent experimental colitis in mice. METHODS: In vitro immunomodulation was assessed by measuring interleukin (IL)-12p70, IL-10, tumor necrosis factor alpha (TNFa) and interferon g (IFNg) release by human peripheral blood mononuclear cells (PBMCs) after 24 h stimulation with 13 live bacterial strains. A murine model of acute TNBS-colitis was next used to evaluate the prophylactic protective capacity of the same set of strains. RESULTS: A strain-specific in vivo protection was observed. The strains displaying an in vitro potential to induce higher levels of the anti-inflammatory cytokine IL-10 and lower levels of the inflammatory cytokine IL-12, offered the best protection in the in vivo colitis model. In contrast, strains leading to a low IL-10/IL-12 cytokine ratio could not significantly attenuate colitis symptoms. CONCLUSION: These results show that we could predict the in vivo protective capacity of the studied lactic acid bacteria (LAB) based on the cytokine profile we established in vitro. The PBMC-based assay we used may thus serve as a useful primary indicator to narrow down the number of candidate strains to be tested inmurine models for their anti-inflammatory potential. | Benoit Foligne Sophie Nutten Corinne Grangette Véronique Dennin Denise Goudercourt Sabine Poiret Joelle Dewulf Dominique Brassart Annick Mercenier Bruno Pot | 2007 | World Journal of Gastroenterology2007，13，2： | 22 |
| 2 | Seasonal,diurnal and nocturnal variations of carbonyl compounds in the semi-urban environment of Orléans,France显示文摘Atmospheric carbonyls were measured at a semi-urban site in Orléans, France, from October 2010to July2011. Formaldehyde, acetaldehyde and acetone were found to be the most abundant carbonyls, with average concentrations of 3.1, 1.0, 2.0 ppb, respectively in summer, 2.3, 0.7, 2.2 ppb, respectively in autumn, 2.2, 1.0, 2.1 ppb, respectively in spring,and 1.5, 0.7, 1.1 ppb, respectively in winter. Photo-oxidation of volatile organic compounds(VOCs) was found to make a remarkable contribution to atmospheric carbonyls in the semi-urban site based on the distinct seasonal and diurnal variations of the carbonyls, as well as the significantly positive correlations between the carbonyls and ozone. The significantly negative correlations between NO x and O_3 as well as the carbonyls and the positive correlations between wind speed and O_3 as well as the carbonyls implied that the carbonyls and O_3 at the semi-urban site were probably formed during air mass transport from neighboring cities. | Zhaohui Jiang Benoit Grosselin Véronique Daele Abdelwahid Mellouki Yujing Mu | 2016 | Journal of Environmental Sciences2016，28，2： | 10 |
| 3 | Biodegradation and brain tissue reaction to poly(DL- lactide- co- glycolide) microspheres显示文摘 | Menei P Daniel V Benoit J P | 1992 | Biomaterials1992，14，： | 2 |
| 4 | Historical collections reveal patterns of diffusion of sweet potato in Oceania obscured by modern plant movements and recombination显示文摘 | Roullier C Benoit L McKey DB Lebot V | 2013 | PNAS2013，110，6： | 1 |
| 5 | Pationts with inflammatory arthritic diseases harbor eievatcd serum and synovial t:luid levels of free and immune-complexed glucose-6 phosphate isomerase (G6PI) 显示文摘 | Scallme M Stohl W Benoit V | 2006 | Biochem Biophys Res Commun2006，349，2： | 1 |
| 6 | VOC photodegradation at the gas-solid interface of a TiO2 photo-catalyst part I :1 - butanol and 1 - butylanmine 显示文摘 | Benoit Marqui6 F Wilkenh6ner U Simon V | 2000 | Journal of Photochemistry and Photobiology A: Chemistry2000，132，3： | 1 |
| 7 | Multiple-object auctions with budget constrained bidders 显示文摘 | Benoit J P Krishna V | 2001 | Review of Economic Studies2001，68，1： | 1 |
| 8 | Replica placement and access policies in tree networks显示文摘 | Benoit A Rehn-Sonigo V Robert Y | 2008 | IEEE Transactions on Parallel and Distributed Systems2008，19，12： | 1 |
| 9 | Magnitude and direction of vesicle dynamics in growing pollen tubes using spatiotemporal image correlation spectroscopy and fluorescence recover), after photobleaching 显示文摘 | Bore J Benoit V Jens K | 2008 | Plant Physiol2008，147，： | 1 |
| 10 | Characterization of brevicin 27, a bacteriocin synthetized by LactobaciHus brevis SB27显示文摘 | Benoit V Mathis R Lefebvre G | 1994 | Curr Microbiol1994，28，1： | 1 |
| 11 | Patients with inflammalory arthritic disease harbor elevated serum and synovial fluid levels of free and immune-complexed glucose 6-phospbate isomerase(G6PI)显示文摘 | Sclaller M Stohl W Benoit V | 2006 | Biochem Biophys Res Commun2006，349，2： | 1 |
| 12 | GATE V6: a ma-jor enhancement of the GATE simulation platform enablingmodelling of CT and radiotherapy 显示文摘 | JAN S BENOIT V BECHEVA E | 2011 | Phys Med Biol2011，56，4： | 1 |
| 13 | Patients with inflammatory arthritic diseases harbor elevated serum and synovial fluid levels of free and immune-eomplexed glueose-6-phosphate isomerase (G6PI)显示文摘 | Schatler M Stohl W Benoit V | 2006 | Biocbem Biophys Res Commun2006，349，2： | 1 |
| 14 | Complement protein Clq directs maerophage polarization and limits inflammasome ac- tivity during the uptake of apoptotic cells显示文摘 | Benoit M E Clarke E V Morgado P | 2012 | J Immunol2012，，： | 1 |
| 15 | Incidence, kinetics, and risk factors of Epstein-Barr virus viremia in pediatric patients after allogeneic stem cell transplantation 显示文摘 | Bordon V Padalko E Benoit Y | 2012 | Pediatr Transplant2012，16，2： | 1 |
| 16 | Effect of mixing energy levels during batch mixing of cement slurries显示文摘 | Hibert A P Kellingary D J Benoit V | 1995 | SPE Drilling & Completion1995，10，1： | 1 |
| 17 | Phytoplankton community structure and primary production in small intertidal estuarine-bay ecosystem(eastem English Channel,France)显示文摘 | FABIEN J SéBASTIEN L BENOIT V | 2007 | Marine Biology2007，157，3： | 1 |
| 18 | Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nucle ar factor-kappaB显示文摘 | Benoit V de-Moraes E Dar N A | 2006 | Oncogene2006，25，42： | 1 |
| 19 | Traffic accident segmentation by means of latent class clustering显示文摘 | Benoit D Geert W Koen V | 2008 | Accident Analysis and Prevention2008，，40： | 1 |
| 20 | Seasonal variation of acid volatile sulfide concentration in sediment cores from three northeastern minnesota lakes显示文摘 | LEONARD E N MATTSON V R BENOIT D A | 1993 | Hydrobiologia1993，271，2： | 1 |
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