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| 1 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 2 | Evidence- based guidelines for cardiovascular disease pre- vention in women: 2007 update 显示文摘 | Mosca L Banka CL Benjamin E J | 2007 | Circulation2007，，： | 1 |
| 3 | Evidence- based guidelines for cardiovascular disease prevention in women: 2007 update 显示文摘 | Mosca L Banka CL Benjamin EJ | 2007 | J Am Coil Cardiol2007，49，11： | 1 |
| 4 | Fetoplacental Oxygenation in an Intrauterine Growth Restriction Rat Model by Using Blood Oxygen Level–Dependent MR Imaging at 4.7 T显示文摘 | Gihad E. Chalouhi Marianne Alison Benjamin Deloison Rokhaya Thiam Gwennhael Autret Daniel Balvay Charles A. Cuenod Olivier Clément Laurent J. Salomon Nathalie Siauve | 2013 | Radiology2013，，1： | 1 |
| 5 | Evidence-based guidelines for cardiovascular disease prevention in women: 2007 update 显示文摘 | Mosca L Banka CL Benjamin EJ | 2007 | J Am Coil Cardiol2007，49，11： | 1 |
| 6 | Effects of exercise on diastasis of the rectus abdominis muscle in the antenatal and postnatal periods : a systematic review 显示文摘 | Benjamin DR van de Water AT Peiris CL | 2014 | Physiotherapy2014，100，1： | 1 |
| 7 | P53 protein and pathogenesis of melanoma and nonmelanoma skin cancer 显示文摘 | Benjamin CL Melnikova VO Ananthas - wamy HN | 2008 | Advances in Experimental Medicine and Biology2008，624，： | 1 |
| 8 | Brief cognitive- behavioral therapy for anxious youth: feasibility and initial outcomes 显示文摘 | Crawley SA Kendall PC Benjamin CL | 2013 | Cogn Behav Pract2013，20，2： | 1 |
| 9 | Anxiety and relat- ed outcomes in young adults 7 to 19 years after receiving treat- ment for child anxiety显示文摘 | Benjamin CL Harrison JP Settipani CA | 2013 | J Consult Clin Psychol2013，81，5： | 1 |
| 10 | Evidence- based guidelines for cardiovascular disease prevention in women: 2007 update显示文摘 | Mosca L Blanka CL Benjamin EJ | 2007 | Circulation2007，115，15： | 1 |
| 11 | Brief cognitive-be- havioral therapy for anxious youth :feasibility and initial outcomes 显示文摘 | Crawley SA Kendall PC Benjamin CL | 2013 | Cogn Behav Pratt2013，20，2： | 1 |
| 12 | Root developmental adaptation to phosphate starvation: better safe than sorry显示文摘 | Benjamin Péret Mathilde Clément Laurent Nussaume Thierry Desnos | 2011 | Trends in Plant Science2011，，8： | 1 |
| 13 | Evidence-based guidelines for cardiovascular disease prevention in women:2007 update 显示文摘 | Mosca L Banka CL Benjamin EJ | 2007 | Circulation2007，115，11： | 1 |
| 14 | Diabetes and cardiovasculardiseas:a statement for vealthcare professionals from the American Heart Association显示文摘 | Gnmdy SM Benjamin CL Burke GL | 1999 | Circulation1999，100，10： | 1 |
| 15 | Use of artificial androgen receptor coactivators to alter myoblast proliferation 显示文摘 | Benjamin CL Jenster G Piedrahita JA | 2004 | J Steroid Biochem n olSiol2004，91，3： | 1 |
| 16 | Evidence-based guidelines for cardiovascular disease prevention in women: 2007 update显示文摘 | Mosca L Banka CL Benjamin EJ | 2007 | Circulation2007，49，11： | 1 |
| 17 | Diabetes and cardiovascular disease Circulation显示文摘 | Grundy SM Benjamin Cl Burke GL | 1999 | 100:11341999，100，： | 1 |
| 18 | Diabetes and cardiovascular diseases显示文摘 | Grundg Sm Benjamin Cl Burke GL | 1999 | Circulation1999，100，： | 1 |
| 19 | Root developmental adaptation to phosphate starvation: better safe than sorry显示文摘 | Benjamin Péret Mathilde Clément Laurent Nussaume Thierry Desnos | 2011 | Trends in Plant Science2011，，： | 1 |
| 20 | Evidence based guidelines for cardiovascular disease prevention in women:2007 update显示文摘 | Mosca L Banka CL Benjamin EJ | 2007 | Circulation2007，115，11： | 1 |
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