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| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 3 | The Polycystic Ovary Syndrome Health-Related Quality of Life Questionnaire (PCOSQ) : a validation 显示文摘 | Jones GL Benes K Clark TL Denham R | 2004 | Hum Reprod2004，19，2： | 1 |
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| 5 | Facial aesthetics and theassignment of personality traits before and after orthognathicsurgery 显示文摘 | Sinko K Jagsch R Benes B | 2012 | Int J Oral Maxillofac Surg2012，41，4： | 1 |
| 6 | Multi-fucus thermal image fusion显示文摘 | Benes R Dvorak P Faundez-Zanuy M | 2013 | Pattern Recognition Letters2013，34，5： | 1 |
| 7 | The restructuring of muscarinic receptor subtype gene transcripts in c-fos knock-out mice 显示文摘 | Benes J Mravec B K vetnansky R | 2013 | Brain Res Bull2013，94，： | 1 |
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| 13 | Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion on-cogene EML4-ALK显示文摘 | Katayama R Khan T M Benes C Lifshits E Ebi H Rivera V M | 2011 | Proc Natl Acad Sci USA2011，108，： | 1 |
| 14 | Combination biomarkers to diagnose sepsis in the critically ill patient显示文摘 | Gibot S Bene MC Noel R | 2012 | Am J Respir Crit Care Med2012，186，1： | 1 |
| 15 | The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments 显示文摘 | Bustin SA Benes V Garson JA Hellemans J Huggett J Kubista M Mueller R Nolan T Pfaffl MW Shipley GL Vandesompele J Wittwer CT | 2009 | Clin Chem2009，55，4： | 1 |
| 16 | Neutrophils as a key cellular terget for angiostain : implications for regulation of angiogenesis and inflammation显示文摘 | Beneli R Morni M Carrozzino F | 2002 | FASEB J2002，16，2： | 1 |
| 17 | Reverse dorsal digital island flap显示文摘 | Bene MD Petrohi R Raimondi P at al | 1994 | J Plast Reconstr Surg1994，93，3： | 1 |
| 18 | Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers har- boring the fusion oncogene EML4-ALK 显示文摘 | Katayama R Khan TM Benes C | 2011 | Proc Nad Acad Sci USA2011，108，18： | 1 |
| 19 | Combination biomarkers to diagnose sepsis in the critically ill patient 显示文摘 | Gibot S Bene MC Noel R | 2012 | Am J Respir Crit Care Med2012，186，1： | 1 |
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