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| 1 | OsDMI3 Is a Novel Component of Abscisic Acid Signaling in the Induction of Antioxidant Defense in Leaves of Rice显示文摘Ca2+ 和 calmodulin (凸轮) 被看了抗氧化剂防卫到在 abscisic 酸(骆驼毛的织物) 的一个重要角色导致了的玩。然而, Ca2+/CaM-dependent 蛋白质 kinase (CCaMK ) 是否涉及这个过程,是未知的。在现在的学习,米饭 CCaMK 的角色, OsDMI3,在导致骆驼毛的织物的抗氧化剂,防卫在米饭(Oryza sativa ) 的叶子被调查植物。有骆驼毛的织物, H2O2,和聚乙烯乙二醇(木钉) 的处理导致了 OsDMI3 和 OsDMI3 的活动的表示,并且 H2O2 在水应力下面为表示和 OsDMI3 的活动的导致骆驼毛的织物的增加被要求。Subcellular 本地化分析证明 OsDMI3 位于原子核,细胞质,和血浆膜。在米饭原物和在米饭原物的 OsDMI3 的 silencing 显示出的 RNA 干扰(RNAi ) 的 OsDMI3 的短暂表示的分析那 OsDMI3 为表示和 superoxide dismutase (草皮) 和过氧化氢酶(猫) 的活动的导致骆驼毛的织物的增加被要求。进一步,氧化损坏由木钉的更高的集中导致了, H2O2 在 OsDMI3 的异种被加重。而且,在原物和 OsDMI3 的异种的 OsDMI3 的 RNAi silencing 的分析证明 H2O2 累积的高水平要求在骆驼毛的织物发信号的 OsDMI3 激活,而是起始的 H2O2 生产导致了由骆驼毛的织物不依赖于在米饭植物的叶子的 OsDMI3 的激活。我们的数据表明 OsDMI3 是在在米饭的导致骆驼毛的织物的抗氧化剂防卫的一个重要部件。 | Ben Shi Lan Ni Aying Zhang Jianmei Cao Hong Zhang Tingting Qin Mingpu Tan Jianhua Zhang Mingyi-Jiang | 2012 | Molecular Plant2012，5，6： | 10 |
| 2 | Cytokine and apoptosis gene polymorphisms influence the outcome of hepatitis C virus infection显示文摘BACKGROUND:Hepatitis C virus (HCV) infection is thought to be chronic and the factors leading to viral clearance or persistence are poorly understood.This study was undertaken to investigate the possibility of a significant relationship between the spontaneous clearance or the persistence of hepatitis C virus (HCV) infection and cytokine and apoptosis gene polymorphisms in Tunisian patients on hemodialysis.METHODS:Polymorphisms of the genes IL-1 (-889 IL-1α,-511 and +3954 IL-1β,IL-1Ra),IL-18 (-137 and-607),IL-12 (-1188) and Apo1/Fas (-670) were determined by PCR-RFLP,PCR-SSP and PCR-VNTR in 100 healthy blood donors and 100 patients infected with HCV and undergoing hemodialysis.The patients were classified into two groups:G1 consisted of 76 active chronic hepatitis patients (positive for HCV RNA) and G2 consisted of 24 hemodialysed patients who spontaneously eliminated the virus (negative for HCV RNA).RESULTS:The frequency of genotype association [-137GC/-607CA] IL-18 was higher in G2 (41.7%) than in G1 (15.8%) (P=0.008;OR=0.26;95% CI,0.10-0.73).We also found a higher frequency of the AA genotype of the Apo1/Fas gene in G2 (41.6%) than in G1 (17.5%) (P=0.026;OR=3.49;95% CI,1.13-10.69).Adjustment for known covariate factors (age,gender and genotype) confirmed these univariate findings and revealed that the genotype association GC-CA of the (-137 and-607) IL-18 gene and the AA genotype of the Apo1/Fas gene were associated with the clearance of HCV (P=0.041 and 0.017,respectively).CONCLUSION:The two genotypes GC-CA of the (-137 and-607) IL-18 polymorphism and the AA genotype of the Apo1/Fas gene influence the outcome of HCV infection in Tunisian patients on hemodialysis. | Leila Ksiaa Cheikhrouhou Imen Sfar Hajer Aounallah-Skhiri Houda Aouadi Salwa Jendoubi-Ayed Taieb Ben Abdallah Khaled Ayed Yousr Lakhoua-Gorgi | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 4 |
| 3 | Association of Fas/Apo1 gene promoter (-670 A/G) polymorphism in Tunisian patients with IBD显示文摘AIM: To detect a possible association between the polymorphism of the (-670 A/G) Fas/Apo1 gene promoter and susceptibility to Crohn's disease (CD) and ulcerative colitis (UC) in the Tunisian population. METHODS: The (-670 A/G) Fas polymorphism was analyzed in 105 patients with CD, 59 patients with UC, and 100 controls using the polymerase chain reaction restriction fragment length polymorphism method. RESULTS: Significantly lower frequencies of the Fas -670 A allele and A/A homozygous individuals were observed in CD and UC patients when compared with controls. Analysis of (-670 A/G) Fas polymorphism with respect to sex in CD and UC showed a significant difference in A/A genotypes between female patients and controls (P corrected = 0.004 in CD patients and P corrected = 0.02 in UC patients, respectively). Analysis also showed a statistically significant association between genotype AA of the (-670 A/G) polymorphism and the ileum localization of the lesions (P corrected = 0.048) and between genotype GG and the colon localization (Pcorrected = 0.009). The analysis ofinflammatory bowel disease patients according to clinical behavior revealed no difference. CONCLUSION: Fas-670 polymorphism was associated with the development of CD and UC in the Tunisian population. | Walid Ben Aleya Imen Sfar Leila Mouelhi Houda Aouadi Mouna Makhlouf Salwa Ayed-Jendoubi Samira Matri Azza Filali Taoufik Najjar Taeib Ben Abdallah Khaled Ayed Yousr Gorgi | 2009 | World Journal of Gastroenterology2009，15，29： | 3 |
| 4 | Preparation of magnetic anion exchange resin and their adsorption kinetic behavior of reactive blue显示文摘磁性的阴离子交换树脂(MD-1 ) 从磁性的 copolymeric 树脂(glycidyl methacrylate-co-divinylbenzene ) 的 quaternization 被准备。为比较,没有 quaternization 和无磁性的树脂(D-1 ) 的磁性的树脂 MD-0 也为吸附过程被综合。吸附主要被贡献,这被发现在第四级的铵组和反应蓝 RXHC 之间的化学相互作用。由于更小的尺寸, MD-1 比 D-1 有更快的吸附和解吸附作用动力学。结合了容易的分离的优点,磁性的阴离子交换树脂被认为比在反应染料的移动的普通阴离子交换树脂优异。 | Chen Dong Shuang Feng Yang Fei Pan Qing Zhou Wei Ben Yang Ai Min Li | 2011 | Chinese Chemical Letters2011，22，9： | 3 |
| 5 | Superselective embolisation of bilateral superior vesical arteries for management of intractable hematuria in context of metastatic bladder cancer显示文摘Hematuria due to locally advanced or metastatic bladder cancer is a common condition and is often a management problem.Percutaneous embolisation is a mini-invasive option to handle this situation.We report a case of a patient with a metastatic bladder cancer and who presented with an abundant hematuria and severe anemia.After failure of endoscopic resections and“flush”of radiotherapy haemostatic and refusal of cystectomy by the patient,he was treated by superselective embolisation of bilateral superior bladder arteries with excellent immediate results.The technique is safe and effective in the short term.The longterm effectiveness requires further investigation. | Ahmed Saadi Abderrazak Bouzouita Mohamed Hedi Rebai Mohamed Cherif Walid Kerkeni Haroun Ayed Amine Derouiche Hatem Rajhi Riadh Ben Slama Najla Mnif Mohamed Chebil | 2017 | Asian Journal of Urology2017，4，2： | 2 |
| 6 | Natural evolution of hepatitis C virus infection in hemodialysis Tunisian patients and CTLA-4 SNP's显示文摘AIM: To analyze the polymorphisms of CTLA-4 gene involved in the response against hepatitis C virus(HCV) infection.METHODS: We recruited 500 hemodialysed patients from several hemodialysis centers, all HCV-antibody positive, spread over different regions of Tunisia, as part of a national survey in 2008 conducted in the laboratory of immunology at the Charles Nicolle hospital Tunisia, classified into two groups G1(PCR+) and G2(PCR-) according to the presence or absence of viral RNA. Of these patients, 307 were followed prospectively on a viral molecular level over a period from 2002 to 2008, divided into two groups based on the persistence and viral clearance. PCR-RFLP was performed for the analysis of SNPs(+49) A/G and(+6230) G/A CTLA-4 for these 500 patients and 358 healthy controls.RESULTS: Analysis of clinical and virological charac-teristics of our cohort suggests a nosocomial infection in our hemodialysed patients with transfusion history as a primary risk factor and a predominance of genotype 1b. The haplotype analysis revealed an increase of frequencies of GG(+49)/(CT60) CTLA-4 in the entire patients group compared to controls(P = 0.0036 and OR = 1.42; 95%CI: 1.12-1.79, respectively). This haplotype is therefore associated with susceptibility to HCV infection. CONCLUSION: Our study suggests a possible role of CTLA-4 polymorphisms in the outcome of HCV infection in the Tunisian hemodialysed population. | Leila Ksiaa Cheikhrouhou Yousr Lakhoua-Gorgi Imen Sfar Salwa Jendoubi-Ayed Houda Aouadi Mouna Makhlouf Khaled Ayed Taieb Ben Abdallah | 2015 | World Journal of Gastroenterology2015，21，35： | 2 |
| 7 | Clinical significance of antinucleosome antibodies in Tunisian systemic lupus erythematosus patients显示文摘 | Ben Ayed M Baklouti S | 2005 | Clin Rheumatol2005，24，3： | 1 |
| 8 | Clinical significance of antinueleosome antibodies in Tunisian systemic lupuserythematosus patients显示文摘 | Haddouk S Ben Ayed M Baklouti S | 2005 | Clin Rheumatol2005，24，3： | 1 |
| 9 | Evaluation of a protocol of spinal anesthesia for cesarean section in a Tunisian maternity unit :hemodynamic repercussions and risk factors for hypotension显示文摘 | Frikha N Ben Ayed M Ellouze O | 2012 | Tunis Med2012，90，10： | 1 |
| 10 | Shape optimization of clinching tools using the response sur- face methodology with Moving Least Square approximation 显示文摘 | OUDJENE M BEN AYED L DELAMEZIERE A | 2009 | Journal of Materials Processing Technology2009，209，： | 1 |
| 11 | Quantitative determination of the polyphenolic content of pomegranate peel显示文摘 | BEN C AYED N METCHE M | 1996 | Zeitschrift fur Lebensmittel Untershung und Forshung1996，203，4： | 1 |
| 12 | Isolation and molec- ular characterisation of Mycobacterium boris from raw milk in Tunisia显示文摘 | Ben K I Boschiroli M L Souissi F et aI | 2011 | Air Health Sci2011，11，1： | 1 |
| 13 | Radiation dose to the pancreas and risk of diabetes mellitus in childhood cancer sur- vivors: a retrospective cohort study 显示文摘 | De Vathaire F E1 - Fayech C Ben Ayed FF | 2012 | Lancet Oncol2012，13，： | 1 |
| 14 | Comparative study of microsatellite profiles of DNA from oil and leaves of two Tunisian olive cultivars显示文摘 | Rayda Ben Ayed Naziha Grati-Kamoun Fabienne Moreau | 2009 | Eur Food Res Technol2009，229，： | 1 |
| 15 | Clinical significance of antinucleosome antibodies in Tunisian systemic lupus erythematosus patients显示文摘 | Haddouk S Ben Ayed M BaMouti S | 2005 | Clin Rheumatol2005，24，3： | 1 |
| 16 | Lymphoid tyrosine phosphatase R620W variant and inflammatory bowel disease in Tunisia显示文摘AIM:To assess the possible association between PTPN22(R620W) gene polymorphism and inflammatory bowel disease(IBD).METHODS:One hundred and sixty-four patients with IBD 105 Crohn's disease(CD) and 59 ulcerative colitis(UC) and 100 healthy controls were recruited.Genotyping of the PTPN22 gene 1858C→T polymorphism was performed by restriction fragment length polymorphism-polymerase chain reaction with Rsa Ⅰ digestion.RESULTS:The genotypic and allelic frequencies of(R620W) PTPN22 gene polymorphism reveal a significant association of the PTPN22 620-W allele with IBD,compared to the healthy control group(OR:17.81,95% CI:4.18-21.86,P = 0.00001).Nevertheless,nodifference in this polymorphism was found between CD and UC patients.No significant association was found between the frequencies of genotypes of the PTPN22 gene with either the clinical features such as sex,age,age at disease onset,and extent of colitis,or the production of serological markers(anti-Saccharomyces cerevisiae antibody in CD and perinuclear anti-neutrophil cytoplasmic antibody in UC).CONCLUSION:These observations confirm the association of IBD susceptibility with the PTPN22 1858T(620-W) allele in Tunisian patients. | Imen Sfar Walid Ben Aleya Leila Mouelhi Houda Aouadi Thouraya Ben Rhomdhane Mouna Makhlouf Salwa Ayed-Jendoubi Houda Gargaoui Taoufik Najjar Taieb Ben Abdallah Khaled Ayed Yousr Gorgi | 2010 | World Journal of Gastroenterology2010，16，4： | 1 |
| 17 | Quality control in tumor marker values:methlogy,results and potential problems显示文摘 | Ben Ayed M Ben Hadj Hmida Y Kassis M | 2001 | Tunis Med2001，79，67： | 1 |
| 18 | Flexibleureteroscopy in the treatment of kidney stone between 2 and 3 cm显示文摘 | Ben S M AI-Qahtani S S Ndoye M et aI | 2011 | ProgUrd2011，21，： | 1 |
| 19 | Multiregionlevel set partitioning of synthetic aperture radar Images显示文摘 | BEN AYED I MITICHE A BELHADJ Z | 2005 | IEEE Transactions on Pattern Analysis and MachineIntelligence2005，27，5： | 1 |
| 20 | Generalized allergy due to zinc in insulin treated with zinc-free insulin 显示文摘 | Ben AI Ksouri H Trabelsi N | 2012 | Acta Diabe- tol2012，49，3： | 1 |
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