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| 1 | 在直肠的癌症的磁性的回声成像调查结果的临床的意义显示文摘 Staging of rectal cancer is essential to help guide clini-cians to decide upon the correct type of surgery and determine whether or not neoadjuvant therapy is indicated. Magnetic resonance imaging (MRI) is currently one of the most accurate modalities on which to base treatment decisions for patients with rectal cancer. MRI can accurately detect the mesorectal fascia, assess the invasion of the mesorectum or surrounding organs and predict the circumferential resection margin. Although nodal disease remains a difficult radiological diagnosis, new lymphographic agents and diffusion weighted imaging may allow identification of metastatic nodes by criteria other then size. In light of this, we have reviewed the literature on the accuracy of specific MRI findings for staging the local extent of primary rectal cancer. The aim of this review is to establish a correlation between MRI findings, prognosis, and available treatment options. | Charles F Bellows Bernard Jaffe Lorenzo Bacigalupo Salvatore Pucciarelli Guiseppe Gagliardi | 2011 | World Journal of Radiology2011，3，4： | 19 |
| 2 | Doublecortin-like kinase 1 exhibits cancer stem cell-like characteristics in a human colon cancer cell line显示文摘Purpose: Colon cancer stem cells (CSCs) are implicated in colorectal cancer carcinogenesis, metastasis, and therapeutic resistance. The identification of these cells could help to develop novel therapeutic strategies. Doublecortin-like kinase 1 (DCLK1) has been viewed as a marker for gastrointestinal stem cells that fuel the self-renewal process, however others view them as a marker of Tuft cells or as an enteroendocrine subtype. The purpose of this study was to use a colon cancer cell line to identify and characterize the stem-like characteristics of the DCLK1+ cell population. Methods: To enrich stem-like cells, HCT116 cells (derived from colon adenocarcinomas) were cultured using serum-free media to form spheres under both normal oxygen and hypoxia condition. DCLK1 transcript expression in the adherent parental cells and spheroids was quantified using quantitative real time reverse transcription- polymerase chain reaction [(q)RT-PCR]. DCLK1 protein expression was determined using flow cytometry. Self-renewal capability from adherent parental cells and spheroids was determined using extreme limiting dilution analysis (ELDA). Results: Under both normal oxygen and hypoxia condition, the adherent parental cells were composed of cells that express low levels of DCLK1. However, spheroids exhibited an increased frequency of cells expressing DCLK1 on both mRNA and protein levels. Cells derived from spheroids also possess stronger self-renewal capability. Conclusions: The higher fraction of DCLK1+ cells exhibited by spheroids and hypoxia reflects the stem-like characteristics of these cells. DCLK1 may represent an ideal marker to study and develop effective strategies to overcome chemo-resistance and relapse of colon cancer. | Lianna Li Charles F. Bellows | 2013 | Chinese Journal of Cancer Research2013，25，2： | 9 |
| 3 | Adipose tissue-derived progenitor cells and cancer显示文摘Recruitment of stem cells and partially differentiated progenitor cells is a process which accompanies and facilitates the progression of cancer.One of the factors complicating the clinical course of cancer is obesity,a progressively widespread medical condition resulting from overgrowth of white adipose tissue(WAT),com-monly known as white fat.The mechanisms by which obesity in uences cancer risk and progression are not completely understood.Cells of WAT secret soluble molecules(adipokines) that could stimulate tumor growth,although there is no consensus on which cell populations and which adipokines are important.Recent reports suggest that WAT-derived mesenchymal stem(stromal) cells,termed adipose stem cells(ASC),may represent a cell population linking obesity and cancer.Studies in animal models demonstrate that adipokines secreted by ASC can promote tumor growth by assisting in formation of new blood vessels,a process necessary for expansion of tumor mass.Importantly,migration of ASC from WAT to tumors has been demonstrated,indicating that the tumor microenvironment in cancer may be modulated by ASC-derived trophic factors in a paracrine rather than in an endocrine manner.Here,we review possible positive and adverse implications of progenitor cell recruitment into the diseased sites with a particular emphasis on the role in cancer progression of progenitors that are expanded in obesity. | Charles F Bellows Mikhail G Kolonin | 2010 | World Journal of Stem Cells2010，2，5： | 2 |
| 4 | Open-angle glaucoma secondary to blood clot in the Schlemm's canal following scleral buckle surgery and its treatment with tPA显示文摘 | Tran CN Bellows AR Hutchinson BT | 2001 | Ophthalmic Surg Lasers2001，32，2： | 1 |
| 5 | 显示文摘 | Bellows DS Howell M Pearson C | 2002 | J Virol2002，76，5： | 1 |
| 6 | Forces on horizontal tubes in gas fluidized beds 显示文摘 | | 1987 | Chem Eng Research Design1987，63，： | 1 |
| 7 | Assessment of yen-tricular function in critically ill patients:limitations of pul-monary artery catheterization显示文摘 | Bellows NL Mangano DT | 1999 | J Cardiothorac Vase Anesth1999，13，5： | 1 |
| 8 | Diabetes mellitus and colorectal cancer prognosis:a meta-analysis显示文摘 | Mills KT Bellows CF Hoffman AE | 2013 | Dis Colon Rectum2013，56，11： | 1 |
| 9 | Surgical management of hemodi alysis-related central venous occlusive disease:atreatment algorithm显示文摘 | Anaya-Ayala JE Bellows PH Ismail N | 2011 | Ann Vasc Surg2011，25，1： | 1 |
| 10 | Observation on 300 cases of ocular war injuries 显示文摘 | Bellows JG | 1947 | Am J Ophthalmol1947，30，3： | 1 |
| 11 | Surgical management of hemodialysis-related central venous oc-clusive disease: a treatment algorithm显示文摘 | Anaya-Ayala JE Bellows PH Ismail N | 2011 | Ann Vase Surg2011，25，1： | 1 |
| 12 | Effects of transforming growth factor-β and epidermal growth factor on cell proliferation and the formation of bone nodules in isolated fetal rat calvaria cells显示文摘 | Antosz ME Bellows CG Aubin JE | 1989 | J Cell Physiol1989，140，2： | 1 |
| 13 | Management of gallstones显示文摘 | Bellows CF Berger DH Crass RA | 2005 | Am Fam Physician2005，72，4： | 1 |
| 14 | Multieentre evaluation of the in vitro activity of linezolid in the Western Pacific显示文摘 | Bell JM Turnidge JD Bellow CH | 2003 | J Antimicrob Chemother2003，51，2： | 1 |
| 15 | Determination of numbers of osteoprogenitors present in isolated fetal rat calvaria cells in vitro 显示文摘 | Bellows CG Aubin JE | 1989 | Der Biol1989，133，： | 1 |
| 16 | insights and applications sustaining ecotourism: insights and implications from two successful case studies显示文摘 | Weinberg A Story Bellows Dara Ekster | 2002 | Society and Natural Resources2002，，15： | 1 |
| 17 | Effect of simulated weightlessness on osteoprogenitor cell number and proliferation in young and adult rats显示文摘 | Basso N Bellows CG Heersche JN | | 0，，01： | 1 |
| 18 | The effects of fluoride on os- teoblast progenitors in vitro 显示文摘 | Bellows CG Heersche JN Aubin JE | 1990 | J Bone Miner Res1990，5，1： | 1 |
| 19 | Whitefly biology显示文摘 | BYRNE D N BELLOWS T S | 1991 | Ann Rev Entomol1991，36，： | 1 |
| 20 | The effect of fluoride on osteoblast progentors in vitor显示文摘 | Bellows CG Heersche JN | 1990 | Bone Miner Res1990，5，11： | 1 |
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