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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Polyamines reduces lipid peroxidation induced by different pro-oxidant agents显示文摘 | Nádia Aléssio Velloso Bellé Gerusa Duarte Dalmolin Graciela Fonini Maribel Antonello Rubin Jo?o Batista Teixeira Rocha | 2004 | Brain Research2004，，2： | 3 |
| 3 | Isomeric Mannich bases derived from ethyl 5-hydroxy-2- methylindole-3-carboxylate 显示文摘 | Bell MR Oesterlin R Beyler AL | 1967 | JMed Chem1967，10，： | 2 |
| 4 | CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infeeted individuals regulate CD4(+ ) and CDS(+ ) HIV specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status 显示文摘 | Kinter AL HennesseyM Bell A | 2004 | J Exp Med2004，200，3： | 1 |
| 5 | Gasdynamic model of turbulent combustion in TNT explosions显示文摘 | Kuhl AL Bell J B Beckner V E | 2011 | Proceedings of the Combustion Institute2011，33，2： | 1 |
| 6 | Non-cardiogenic pul-monary oedema in vascular surgery 显示文摘 | Pararajasingam R Nicholson ML Bell PR ef al | 1999 | Eur J Vase Endovasc Surg1999，17，2： | 1 |
| 7 | Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer:molecular analysis of the IDEAL/INTACT gefitinib trials显示文摘 | Bell DW Lynch TJ Haserlat SM ct al | | 0，，31： | 1 |
| 8 | CD25^+ CD4^+ regulatory T- cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4^ and CD8 + HIV-specific T-cell immune responses in vitro and are associated with favorable clinical markers of disease status 显示文摘 | Kinter AL Hennessey M Bell A | 2004 | J Exp Med2004，200，3： | 1 |
| 9 | Hyperbaric oxygen: its uses, mechanisms of actiQn and outcomes 显示文摘 | Gill AL Bell CN | 2004 | Q J Med2004，97，7： | 1 |
| 10 | Isomeric mannich bases derived from ethyl 5 - hydroxy - 2 - methylindole - 3 - carboxylate 显示文摘 | Bell MR Osterlin R Beyler AL | 1967 | J Med Chem1967，10，2： | 1 |
| 11 | Hyperbaric oxygen:its uses, mechanisms of action and outcomes显示文摘 | Gill AL Bell CN | 2004 | QJM2004，97，： | 1 |
| 12 | Association between the dietary approaches to hypertension diet and hypertension in youth with diabetes mellitus显示文摘 | GiJnther AL Liese AD Bell RA | 2009 | Hypertension2009，53，1： | 1 |
| 13 | Multiresponse parameter estimation for finite-element model updating using nondestructive test data 显示文摘 | Bell E S Sanayei M Javdekar C N el al | 2007 | Journal of Structural Engineering2007，133，8： | 1 |
| 14 | Hyperbaric oxygen: its uses, mechanisms of action and outcomes显示文摘 | Gill AL Bell CN | 2004 | QJM2004，97，7： | 1 |
| 15 | CD25+ CD4+ regulatory T cells from the peripheral blood of asymptomarie HIV-infeeted individuals regulate CD4+ and CD8+ HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status显示文摘 | Hennessey M Bell A | 2004 | J Exp MOd2004，200，3： | 1 |
| 16 | Herpes zoster and postherpetic neuralgiaprevention and management显示文摘 | Fashner J Bell AL | 2011 | Am Fam Physician2011，83，12： | 1 |
| 17 | Herpes zoster and postherpetic neuralgia: pre- vention and management 显示文摘 | Fashner J Bell AL | 2011 | Am Fam Physician2011，83，12： | 1 |
| 18 | Study of erythropoietin in treatment of anemia in patients with rheumatoid arthritis显示文摘 | Murphy EA Bell AL Wojtulewski J | 1994 | Br Med J1994，309，： | 1 |
| 19 | Low temperature nano-tribological study on a functionally graded tribological coating using nanoscratch tests显示文摘 | CHEN J BELL G A BEAKE B D ct al | 2011 | Tribology Letters2011，43，3： | 1 |
| 20 | Hyperbaric oxygen its uses mechanisms of action and outcomes显示文摘 | Gill AL Bell CAN | 2004 | Quart J Med2004，97，： | 1 |
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