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| 1 | Prevalence of Carbapenem-Resistant Klebsiella Pneumoniae (CRKP) and the Distribution of Class 1 Integron in Their Strains Isolated from a Hospital in Central China显示文摘我们的学习的目的是调查 Carbapenem 抵抗的 Klebsiella pneumoniae (CRKP ) 和班的基因特征的流行的目的在临床的 Klebsiella pneumoniae 拉紧的多药 resistance.Methods 上的 CRKP 的 1 integron 在华中从一所医院的多重部门被收集。CRKP 紧张在 isolates 之中被识别,并且 CRKP 紧张的抗菌素危险性被分析。聚合酶链反应(PCR ) 被采用放大类 1 个 integron 变量区域。integron 基因结构与酶消化和 DNA 定序技术被分析。在班 1 integron 和药抵抗之间的关系被分析完全, 955 Klebsiella pneumoniae 拉紧的 statistically.Results 从医院的改变的地点被孤立,并且(12.3%) 117 作为 CRKP 他们被识别,与在 2013 的8.9%的分离率( 26/292 ),11.3%( 38/336 )在 2014 和16.2%( 53/327 )在 2015 ,哪个表演到年的一个增加的趋势。(52/117 )44.4% 与 ICU 的标本 CRKP 紧张被分开,并且(72/117 )61.5% 从唾沫。超过 95% CRKP 紧张对 ampicillin/sulbactam, aztreonam, imipenem, meropenem, ceftazidme, cefotaxime, cefepime,和 piperacillin 抵抗,当相对低的抵抗的率在 tigecycline (12.8%) 和 colistin (35.9%) 被发现时。班 1 integron 在 77.8% 被检测(91/117 ) CRKP 紧张。CRKP 的班 1 integron 显著地与抗菌素抵抗被相关到 tobramycin, gentamicin 和 amikacin (所有 P < 0.01 ) 。班 1 integron 的可变区域的基因盒子分析证明 aadA2 占 64.8%(59/91 ) , aacA4-catB8-aadA1 23.1%(21/91 ) ,并且 aadA2-dfrA25 12.1%(11/91 ).Conclusions CRKP 在他们的中国,和大多数在临床的设置有一个增加的趋势对多重抗菌素抵抗。在 CRKP 的班 1 integron 有强壮的能力从环境捕获对 aminoglycosides 抗菌素抵抗的基因,与象最流行的 aadA2 基因。 | QinOu WenfangLi BeiLi ChunfangYu | 2017 | Chinese Medical Sciences Journal2017，32，2： | 8 |
| 2 | Vaterite or aragonite observed in the prismatic layer of freshwater-cultured pearls from South China显示文摘A prismatic layer is present in both freshwater-cultured pearls and seawater-cultured pearls. The phase structure of the prismatic layer of freshwater-cultured pearls is investigated for the first time and novel findings are reported in this paper. X-ray diffraction (XRD), optical microscopy (OM) and micro-infrared (IR) spectroscopy were used to characterize the crystallized layers of high and low-quality freshwater-cultured pearls. Results show that there is no calcite in the prismatic layer of freshwater-cultured pearls, which is different from what was found for seawater-cultured pearls. We found that an aragonite phase was present in the prismatic layer of high-quality freshwater-cultured pearls and that a vaterite or aragonite phase was present in low-quality pearls. Based on this study an internal factor that influences the quality of freshwater-cultured pearls is discussed. | Hongyan Ma Anan Su Beili Zhang Ru-Kang Li Longchang Zhou Baoli Wang | 2009 | Progress in Natural Science:Materials International2009，19，7： | 7 |
| 3 | TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer显示文摘Gastric can cer is one of the most comm on cancers worldwide and is the third leadi ng cause of cancer-related deaths globally. Although significant progress has been made in the diagnosis and treatment for the cancer, less improvement has been made in overall survival rate. Thus, there is an urgent need for a better understanding of the biological aspects of the cancer. The transcription factor transcription factor 7-like 1 (TCF7L1) is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in gastric cancer has seldom been discussed. In the present study, by using the Cancer Genome Atlas dataset analysis, we demonstrated that patients with higher expression of TCF7L1 could be used to reflect prognosis. An examination of the mechanisms demonstrated that TCF7L1 could positively regulate antioxidant response in gastric cancer cells by positively regulating Keap1/NRF2 [Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2] pathway. Collectively, our data demonstrated that TCF7L1 is a novel marker for predicting overall survival of gastric cancer and provided the possible underlying molecular mechanism. | Beili Zhang Jugang Wu Yantao Cai Meng Luo Bing Wang Yan Gu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，4： | 3 |
| 4 | Multi-objective optimization in quantum parameter estimation显示文摘We investigate quantum parameter estimation based on linear and Kerr-type nonlinear controls in an open quantum system, and consider the dissipation rate as an unknown parameter. We show that while the precision of parameter estimation is improved,it usually introduces a significant deformation to the system state. Moreover, we propose a multi-objective model to optimize the two conflicting objectives:(1) maximizing the Fisher information, improving the parameter estimation precision, and(2)minimizing the deformation of the system state, which maintains its fidelity. Finally, simulations of a simplified ε-constrained model demonstrate the feasibility of the Hamiltonian control in improving the precision of the quantum parameter estimation. | BeiLi Gong Wei Cui | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，4： | 2 |
| 5 | EGFR/BRAF/MEK co-inhibition for EGFR-mutated lung adenocarcinoma patients with an acquired BRAF^(V600E) mutation: a case report and review of literature显示文摘Despite the promising initial anti-tumor efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors(EGFR-TKIs),most advanced non-small-cell lung cancers(NSCLCs)progress eventually due to therapeutic resistance.V-Raf murine sarcoma viral oncogene homolog B1(BRAF)^(V600E) mutation has been considered as an uncommon mutation that contributes to acquired resistance for EGFR-TKIs.In the presented case,BRAF^(V600E) mutation was detected as an acquired resistance-mediated mutation in a patient treated with osimertinib(a third-generation EGFR-TKI).The presented patient achieved partial regression and ongoing PFS of four months after the co-inhibition of osimertinib plus dabrafenib(BRAF inhibitor)and trametinib(MEK inhibitor).Our case further enriches the clinical evidence of the efficacy of EGFR/BRAF/MEK co-inhibition in patients with an acquired BRAF^(V600E) mutation,consistent with the review of the literature(eight cases).Additionally,our case highlights the important role of sample type,method,and platform of gene detection in patient management,life quality,and prognosis,as well as the understanding of acquired resistance mechanism. | Ran Zeng Lifeng Luo Xianwen Sun Zhiyao Bao Wei Du Ranran Dai Wei Tang Beili Gao Yi Xiang | 2021 | Cancer Drug Resistance2021，4，4： | 2 |
| 6 | T-cell vaccination leads to suppression of intrapancreatic Th17 cells through Stat3-mediated RORyt inhibition in autoimmune diabetes显示文摘有使失去活性的 autoreactive T 房间的免疫是改善的一条有效治疗学的途径自体免疫的疾病,当调整 autoreactive T 房间的内在的机制完全没被理解时。这研究测试了 T 房间种痘(TCV ) 禁止的假设在通过 Th17 房间的抑制的老鼠的自体免疫的糖尿病。结果显示出在类型 1 糖尿病(T1D ) 的减少的多糖症作为与控制相比由多重低剂量的 streptozotocin (MLD-STZ ) 导致了的那个 TCV 处理,保存了健康胰腺的小岛的数字并且增加了在小岛的胰岛素的生产。进一步的学习表明 TCV 显著地减少了在通过 mRNA 的显著抑制渗入淋巴细胞(IPL ) 的 intrapancreatic 的 -17 和 IL-23 retinoic 铺平的两 interleukin (IL ) 的生产酸相关的孤儿受体 γ t (RORγ t ) 并且信号变换器和抄写 3 的使活跃之物(Stat3 ) phosphorylation。导致 TCV 的 Th17 抑制的角色进一步在 sub-diabetogenic 老鼠与极化的 Th17 房间在采纳转移实验被验证,它类似于 anti-IL-17 抗体处理的效果。一起,我们的学习证明 intrapancreatic Th17 房间抑制和健康小岛保藏由 TCV 在 T1D 的处理起一个重要作用。 | Min Wang Liu Yang Xiaoyan Sheng Weilei Chen Haiqing Tang Hongguang Sheng Beili Xi Ying Qin Zang | 2011 | Cell Research2011，21，9： | 2 |
| 7 | Lessons from the Development of Regulation of General Insurance in Australia显示文摘 | Beilis | 2002 | Actuarial Communications2002，3，2： | 1 |
| 8 | The psychobiology of neglect 显示文摘 | De Beilis MD | 2005 | Child Mal-treat2005，10，2： | 1 |
| 9 | Steel surface modifica-tion by pulsed air arc treatment显示文摘 | Parkansky N Beilis I I Gindin D | 2010 | Surface&Coatings Technolo-gy2010，205，： | 1 |
| 10 | Electrode erosion and coating properties in pulsed air arc deposition of WC-based hard alloys显示文摘 | Parkansky N Beilis I I Rapoport L | 1998 | Surface and Coatings Technology1998，，105： | 1 |
| 11 | Androgen receptand de- fects:histandical,clinical,and molecular perspectives显示文摘 | Quigley CA Beilis AD Marschke KB | 1995 | Endocrine Reviews1995，16，： | 1 |
| 12 | Electrode erosion and coating properties in pulsed air arc deposition of WC-based hard alloys 显示文摘 | Parkansky N Beilis I I Rapoport L | 1998 | Surface and Coatings Technology1998，105，1： | 1 |
| 13 | Anode mass loss during pulsed air arc deposition显示文摘 | Parkansky N Beilis I I Boxman R L | 1998 | Surface and Coatings Technology1998，，108： | 1 |
| 14 | Brain natriuretic peptide is related to carotid plaques and predicts atherosclerosis in pre-dialysis patients with chronic kidney disease显示文摘 | Wenyan Zhou Zhaohui Ni Zanzhe Yu Beili Shi Qin Wang | 2012 | European Journal of Internal Medicine2012，，6： | 1 |
| 15 | 2D expansion of the low-density interelectrode vacuum arc plasma jet in an axial magnetic field显示文摘 | Keidar M Beilis I Boxman R L | 1996 | Journal of Physics D: Applied Physics1996，29，7： | 1 |
| 16 | Anodemassloss during pulsed air arc deposition显示文摘 | Beilis II | 1998 | Surface and Coatings Technology1998，，108： | 1 |
| 17 | Theoretical study of plasma expansion in a magnetic field in a disk anode vacuum arc显示文摘 | Beilis I I Keidar M Boxman R L | 1998 | Journal of Physics D- Applied Physics1998，83，2： | 1 |
| 18 | Electrode erosion and coating properties in pulsed air arc deposition of WC-based hard alloys显示文摘 | Beilis II | 1998 | Surface and Coatings Technology1998，，105： | 1 |
| 19 | Prevention and treatment ofnonalcoholic fatty liver disease 显示文摘 | Targher G Beilis A Fomengo P | 2010 | Dig Liver Dis2010，42，5： | 1 |
| 20 | Improvement of thermal stability of UV curable pressure sensitive adhesive by surface modified silica nanoparticles显示文摘 | PANG Beili RYU Chong-Min KIM Hyung-I1 | 2013 | Materials Science and Engineering B2013，178，18： | 1 |
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