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| 1 | 骨髓增生异常综合征表皮生长因子受体的表达及其与细胞凋亡的关系显示文摘目的 探索骨髓增生异常综合征 (MDS)造血细胞中表皮生长因子受体 (EGFR)表达及其与细胞凋亡的关系。方法 取 18例MDS患者骨髓有核细胞经离心涂片机制片 ,用免疫酶标记方法(碱性磷酸酶 抗碱性磷酸酶系统 ,APAAP)及TdT介导的dUTP缺口末端 (荧光素 )标记 (TUNEL)法先后在同一标本上检测EGFR表达和凋亡信号。 9名正常人骨髓作对照。另外 ,18例MDS中有 15例、9名正常人中有 6名经流式细胞仪分选CD3 4+细胞并制备涂片后按上述方法进行EGFR和凋亡检测 ,并分析两者间的关系。结果 ①MDS骨髓细胞EGFR表达 [(38.6± 2 4.6 ) %]高于正常对照 [(18.1±14 0 ) %](P <0 .0 5 ) ;②MDS细胞凋亡主要发生在EGFR阴性细胞 (16 .1%) ,EGFR阳性细胞中凋亡细胞仅占 1.4%(P <0 .0 1) ,EGFR表达与细胞凋亡呈负相关 (r =- 0 .70 1;tr=3.6 0 ;P <0 .0 1) ;③CD3 4+细胞EGFR表达阳性率RAEB RAEB t CMML组高于RA RAS组 ,分别为 (2 0 .6± 2 7.9) %和 (8.9±11 8) %,但差异无显著性 ,细胞凋亡率RAEB RAEB t CMML组低于RA RAS组 ,分别为 (18.2± 12 5 ) %和 (4 5 .2± 2 0 .5 ) %(P <0 .0 5 )。结论 MDS造血细胞过度表达EGFR。EGFR表达增高可能预示MDS的恶性增殖倾向并通过某种途径抑制细胞凋亡。 | 李晓 浦权 Cassandra Beckham Joachim H.Deeg | 2003 | 中华血液学杂志2003，24，1： | 2 |
| 2 | Clinical significance of multi-leaf collimator positional errors for volumetric modulated arc therapy显示文摘 | Mike Oliver Isabelle Gagne Karl Bush Sergei Zavgorodni Will Ansbacher Wayne Beckham | 2010 | Radiotherapy and Oncology2010，，3： | 2 |
| 3 | Initial management of acute bacterial meningitis in adults:summary of IDSA guidelines显示文摘 | Beckham J D Tyler K L | 2006 | Rev Neurol Dis2006，3，2： | 1 |
| 4 | Color preference and flight habit s of thrips associated with cotton显示文摘 | Beckham C M | 1969 | J Econ Entomol1969，62，： | 1 |
| 5 | Bioactivities of gossypol,6-methoxygossypol,and 6,6′-dimethoxygossypol显示文摘 | Wang X Beckham T H Morris J C | 2008 | Journal of Agricultural and Food Chemistry2008，56，12： | 1 |
| 6 | Reductions in platelet contractile force correlate with duration of cardiopulmonary bypass and blood loss in patients undergoing cardiac surgery显示文摘 | Brouse CF Beckham J | 2002 | Thromb Res2002，105，： | 1 |
| 7 | Self-efficacy and Adjustment in Cancer Patients: A Preliminary Report显示文摘 | Beckham J C Burker E J Lytle B L | 1997 | Behav Med1997，23，3： | 1 |
| 8 | 显示文摘 | Deeg HJ Beckham C Loken MR | 2000 | Leuk Lymphoma2000，37，： | 1 |
| 9 | Comparison of methods for improved RNA extraction from blood for early detection of Classical swine fever virus by real-time reverse transcription polymerase chain reaction显示文摘 | Das A Beckham T R McIntosh M T | 2011 | Abstract J Vet Diagn Invest2011，23，4： | 1 |
| 10 | Soluble TNF receptor fusion protein(etanereept) for the treatment of myelodysplastic syndrome: a pilot study显示文摘 | Deeg H J Gotlib J Beckham C | 2002 | Leukemia2002，16，： | 1 |
| 11 | Lignin valorization:Improving lignin processing in the biorefinery 显示文摘 | RAGAUSKAS A J BECKHAM G T BIDDY M J | 2014 | Science2014，344，12： | 1 |
| 12 | 显示文摘 | Gersuk GM Beckham C Loken MR | 1998 | Br J Haematol1998，103，： | 1 |
| 13 | Comparing planning time, delivery time and plan quality for IMRT, RapidArc and Tomotherapy显示文摘 | Oliver M Ansbacher W Beckham W A | 2009 | J Appl Clin Med Phys2009，10，4： | 1 |
| 14 | Lignin valorization:improving lignin processing in the biorefinery显示文摘 | RAGAUSKAS A J BECKHAM G T BIDDY M J | 2014 | Science2014，344，6185： | 1 |
| 15 | Autophagy is in-creased in prostate cancer cells overexpression acid ceram-idase and enhances resistance to C6 ceramide显示文摘 | Turner LS Chenq JC Beckham TH | 2011 | ProstateCancer Prostatic Dis2011，14，1： | 1 |
| 16 | Recovery of cardiac function after standard hypotbermic storage versus preservation with Peg-Hemoglobin 显示文摘 | Jones BU Serna DL Beckham G | 2001 | ASAIO J2001，47，3： | 1 |
| 17 | Comparison of kilo- voltage x-ray and electron beam dose distributions for radiotherapy of the sternum显示文摘 | Keall P Monti di Sopra F Beckham W | 1999 | Med Dosim1999，24，2： | 1 |
| 18 | Trail of trazodone for posttraumatic stress disorder using a multiple baseline group design显示文摘 | Hertzberg MA Feldman ME Beckham JC | 1996 | J Clin Psychopharmacol1996，16，： | 1 |
| 19 | Self efficacy and ad justment in cancer patients: A preliminary report 显示文摘 | Beckham JC Burker Lytle BL | 1997 | Behav Med1997，23，3： | 1 |
| 20 | Supplementary ground geophysics for airborne electromagnetic salinity survey over Jemalong-Wylders area显示文摘 | Odins J A Beckham J O'Neill D J | 1995 | Exploration Geophysics1995，26，： | 1 |
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