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| 1 | Hepatitis B virus replication显示文摘Hepadnaviruses,including human hepatitis B virus(HBV),replicate through reverse transcription of an RNAintermediate,the pregenomic RNA(pgRNA).Despite thiskinship to retroviruses,there are fundamental differencesbeyond the fact that hepadnavirions contain DNAinstead of RNA.Most peculiar is the initiation of reversetranscription:it occurs by protein-priming,is strictlycommitted to using an RNA hairpin on the pgRNA,ε,as template,and depends on cellular chaperones;moreover,proper replication can apparently occur onlyin the specialized environment of intact nucleocapsids.This complexity has hampered an in-depth mechanisticunderstanding.The recent successful reconstitution inthe test tube of active replication initiation complexesfrom purified components,for duck HBV(DHBV),now allows for the analysis of the biochemistry ofhepadnaviral replication at the molecular level.Here wereview the current state of knowledge at all steps of thehepadnaviral genome replication cycle,with emphasison new insights that turned up by the use of such cell-free systems.At this time,they can,unfortunately,not be complemented by three-dimensional structurainformation on the involved components.However,atleast for the ε RNA element such information is emerging,raising expectations that combining biophysics withbiochemistry and genetics will soon provide a powerfuintegrated approach for solving the many outstandingquestions.The ultimate,though most challenging goal,will be to visualize the hepadnaviral reverse transcriptasein the act of synthesizing DNA,which will also havestrong implications for drug development. | Juergen Beck Michael Nassal | 2007 | World Journal of Gastroenterology2007，13，1： | 54 |
| 2 | Hypertriglyceridemia-induced pancreatitis: A case-based review显示文摘Hypertriglyceridemia is an established cause of pancreatitis. In a case-based approach, we present a review of hypertriglyceridemia and how it can cause pancreatitis. We outline how to investigate and manage such patients. A 35 year old man presented to the emergency department with abdominal pain and biochemical evidence of acute pancreatitis. There was no history of alcohol consumption and biliary imaging was normal. The only relevant past medical history was that of mild hyperlipidemia, treated with diet alone. Physical exam revealed epigastric tenderness, right lateral rectus palsy, lipemia retinalis, bitemporal hemianopsia and a delay in the relaxation phase of his ankle reflexes. Subsequent laboratory investigation revealed marked hypertriglyceridemia and panhypopituarism. An enhanced CT scan of the head revealed a large suprasellar mass impinging on the optic chiasm and hypothalamus. The patient was treated supportively; thyroid replacement and lipid lowering agents were started. He underwent a successful resection of a craniopharyngioma. Post- operatively, the patient did well on hormone replacement therapy. He has had no further attacks of pancreatitis. This case highlights many of the factors involved in the regulation of triglyceride metabolism. We review the common causes of hypertriglyceridemia and the proposed mechanisms resulting in pancreatitis. The incidence and management of hypertriglyceridemia- induced pancreatitis are also discussed. | S Ian Gan Alun L Edwards Christopher J Symonds Paul L Beck | 2006 | World Journal of Gastroenterology2006，12，44： | 35 |
| 3 | 对护理本科生压力的影响因素调查显示文摘目的 :调查护理本科生常见的压力影响因素。方法 :对我国 3所医学院校的2 5 2名护理本科生 ,采用“个人资料问卷”及“Beck -Sri vastava压力量表”进行调查 ,对结果进行描述性相关分析。结果 :对压力有影响的个人资料依次为 :家庭子女数、家庭关系、社会实践(负相关 )、家庭收入 (负相关 )。结论 :家庭子女数、家庭关系、社会实践及家庭收入对护理本科生压力的产生有一定影响。 | 何贵蓉 Deborah Beck | 2003 | 护理研究2003，17，09A： | 39 |
| 4 | Multilineage potential of adult human mesenchymal stem cells显示文摘 | Pittenger MF Mackay AM Beck SC | | 0，，： | 18 |
| 5 | 全球大停电的经验教训显示文摘根据国际能源机构的预测,在未来20多年里,发展中国家和新兴国家的耗电量将增加220%,而工业化国家则仅增加37%。现有电力系统负荷的大幅度增加将产生瓶颈效应和可靠性问题。历年发生的欧美州大停电清楚地表明,相邻系统间的紧密电气耦合对于重负荷互联系统而言,可能存在无法控制的级联事故风险。介绍美加大停电和欧洲大停电事件,讨论大停电的经验教训。对避免环流、防止电压崩溃等解决大型电力系统稳定性问题的措施及“防火墙”的实施进行了说明。阐述涉及系统改善的高压直流输电(HVDC)和灵活交流输电(FACTS)技术的优点。 | Gǖnther Beck Dusan Povh Dietmar Retzmann Erwin Tehsch | 2007 | 中国电力2007，40，10： | 11 |
| 6 | 亚洲首个500kV可控串补(TCSC)工程(Ⅱ)——天广交流输变电平果变电站可控串补控制与保护系统设计方案显示文摘串联补偿广泛应用于增加高电压、长距离和大负荷送电系统的稳定性。电力电子技术的使用使串联补偿具有更大的灵活性与实用性,其优势可以从分2段布置的电容器组中看出来,其中可控串补(TCSC)和固定串补(FSC)设备均放在同一平台上。每段都使用一个独立的旁路断路器来分别将电容器组投入或退出(旁路)。《国际电力》在2004年第4期上介绍了西门子公司承接的中国天广平果站可控串补工程的一次系统设计,本期将介绍该工程的控制与保护系统设计方案。 | K Braun H Spachtholz M Beck 周彦 彭饱书 龚天森 | 2004 | 国际电力2004，8，6： | 8 |
| 7 | Finance and the sources of growth显示文摘 | Thorsten Beck Ross Levine Norman Loayza | 2000 | Journal of Financial Economics2000，，1： | 7 |
| 8 | 包括p16、ProExC或HPV原位杂交在内的一组3个标记物最适于区分原发性子宫内膜腺癌和宫颈腺癌显示文摘 | Kong C S Beck A H Longacre T A 黄文斌(摘译) | 2010 | 临床与实验病理学杂志2010，26，5： | 7 |
| 9 | Speckle tracking echocardiography to assess regional ventricular function in patients with apical hypertrophic cardiomyopathy显示文摘AIM To explore regional systolic strain of midwall and endocardial segments using speckle tracking echocardiography in patients with apical hypertrophic cardiomyopathy(HCM).METHODS We prospectively assessed 20 patients(mean age 53 ± 16 years,range:18-81 years,10 were male),with apical HCM. We measured global longitudinal peak systolic strain(GLPSS) in the midwall and endocardium of the left ventricle. RESULTS The diastolic thickness of the 4 apical segments was 16.25 ± 2.75 mm. All patients had a normal global systolicfunction with a fractional shortening of 50% ± 8%. In spite of supernormal left ventricular(LV) systolic function,midwall GLPSS was decreased in all patients,more in the apical(-7.3% ±-8.8%) than in basal segments(-15.5% ±-6.93%),while endocardial GLPPS was significantly greater and reached normal values(apical:-22.8% ±-7.8%,basal:-17.9% ±-7.5%). CONCLUSION This study shows that two-dimensional strain was decreased mainly confined to the mesocardium,while endocardium myocardial deformation was preserved in HCM and allowed to identify subclinical LV dysfunction. This transmural heterogeneity in systolic strain had not been previously described in HCM and could be explained by the distribution of myofibrillar disarray in deep myocardial areas. The clinical application of this novel finding may help further understanding of the pathophysiology of HCM. | María Cristina Saccheri Tomás Francisco Cianciulli Luis Alberto Morita Ricardo JoséMéndez Martín Alejandro Beck Juan Enrique Guerra Alberto Cozzarin Luciana Jimena Puente Lorena Romina Balletti Jorge Alberto Lax | 2017 | World Journal of Cardiology2017，9，4： | 7 |
| 10 | TBCs for Gas Turbines under Thermomechanical Loadings: Failure Behaviour and Life Prediction显示文摘 | Tilmann Beck Olena Trunova Roland Herzog Lorenz Singheiser | 2013 | Journal of Energy and Power Engineering2013，7，4： | 7 |
| 11 | AFP, AFP-L3, DCP, and GP73 as markers for monitoring treatment response and recurrence and as surrogate markers of clinicopathological variables of HCC显示文摘 | Kentaroh Yamamoto Hiroshi Imamura Yutaka Matsuyama Yukio Kume Hitoshi Ikeda Gary L. Norman Zakera Shums Taku Aoki Kiyoshi Hasegawa Yoshifumi Beck Yasuhiko Sugawara Norihiro Kokudo | 2010 | Journal of Gastroenterology2010，，12： | 6 |
| 12 | Reaching out: Access to and use of banking services across countries显示文摘 | Thorsten Beck Asli Demirguc-Kunt Maria Soledad Martinez Peria | 2007 | Journal of Financial Economics2007，，1： | 6 |
| 13 | 血管瘤的临床表现及处理显示文摘The presentation and management of heman- giomas. Beck DO, Gosain AK. Plast Reconstr Surg, 2009, 123(6):181e-91e. | Beck DO Gosain AK | 2009 | 中国口腔颌面外科杂志2009，7，4： | 6 |
| 14 | Pre-osteoblastic MC3T3-E1 cells promote breast cancer growth in bone in a murine xenograft model显示文摘The bones are the most common sites of breast cancer metastasis. Upon arrival within the bone microenvironment, breast cancer cells coordinate the activities of stromal cells, resulting in an increase in osteoclast activity and bone matrix degradation. In late stages of bone metastasis, breast cancer cells induce apoptosis in osteoblasts, which further exacerbates bone loss. However, in early stages, breast cancer cells induce osteoblasts to secrete inflammatory cytokines purported to drive tumor progression. To more thoroughly evaluate the role of osteoblasts in early stages of breast cancer metastasis to the bones, we used green fluorescent protein-labeled human breast cancer cell lines MDA-MB-231 and MDA-MB-435, which both induce osteolysis after intra-femoral injection in athymic mice, and the murine pre-osteoblastic cell line MC3T3-E1 to modulate osteoblast populations at the sites of breast cancer metastasis. Breast cancer cells were injected directly into the femur with or without equal numbers of MC3T3-E1 cells. Tumors grew significantly larger when co-injected with breast cancer cells and MC3T3-E1 cells than injected with breast cancer cells alone. Osteolysis was induced in both groups, indicating that MC3T3-E1 cells did not block the ability of breast cancer cells to cause bone destruction. MC3T3-E1 cells promoted tumor growth out of the bone into the extraosseous stroma. These data suggest that breast cancer cells and osteoblasts communicate during early stages of bone metastasis and promote tumor growth. | Thomas M. Bodenstine Benjamin H. Beck Xuemei Cao Leah M. Cook Aimen Ismail J. Kent Powers Andrea M. Mastro Danny R. Welch | 2011 | Chinese Journal of Cancer2011，30，3： | 5 |
| 15 | Hematopoietic cell transplantation for Crohn’s disease;is it time?显示文摘AIM: To review all studies in the literature that have assessed Hematopoietic cell transplantation (HCT) and Crohn’s disease (CD) with the ultimate aims of determining if this is a viable treatment option for those with CD. A secondary aim was to review the above literature and determine if the studies shed further light on the mechanisms involved in the pathogenesis of CD. METHODS: An extensive Medline search was performed on all articles from 1970 to 2005 using the ; bone marrow transplant, stem cell, hematopoietic cell, Crohn’s disease and inflammatory bowel disease. RESULTS: We identified one case in which a patient developed CD following an allogeneic HCT from a sibling suffering with CD. Evidence for transfer of the genetic predisposition to develop CD was also identified with report of a patient that developed severe CD following an allogeneic HCT. Following HCT it was found that the donor (that had no signs or symptoms of CD) and the recipient had several haplotype mismatches in HLA class Ⅲ genes in the IBD3 locus including a polymorphism of NOD2/CARD15 that has been associated with CD. Thirty three published cases of patients with CD who underwent either autologous or allogeneic HCT were identified. At the time of publication 29 of these 33 patients were considered to be in remission. The median follow-up time was seven years, and twenty months for allogeneic and autologous HCT respectively.For patients who underwent HCT primarily for treatment of their CD there have been no mortalities related to transplant complications. CONCLUSION: Overall these preliminary data suggest that both allogeneic and autologous HCT may be effective in inducing remission in refractory CD. Thissupports the hypothesis that the hematolymphatic cells play a key role in CD and that resetting of the immune system may be a critical approach in the management or cure of CD. | Y Leung M Geddes J Storek R Panaccione PL Beck | 2006 | World Journal of Gastroenterology2006，12，41： | 5 |
| 16 | Randomized Trial Evaluating Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema显示文摘 | Michael J. Elman Lloyd Paul Aiello Roy W. Beck Neil M. Bressler Susan B. Bressler Allison R. Edwards Frederick L. Ferris Scott M. Friedman Adam R. Glassman Kellee M. Miller Ingrid U. Scott Cynthia R. Stockdale Jennifer K. Sun | 2010 | Ophthalmology2010，，6： | 5 |
| 17 | New insights for the catalytic oxidation of cyclohexane to K-A oil显示文摘Au-based catalysts have been reported to be active in the cyclohexane oxidation to K-A oil, but they showed some limitiations in terms of productivity, selectivity and required reaction conditions. The possibility to overcome some of these limits has been explored coupling Au with Cu, which can be suitable for undergoing the electron-switch in the initial step of the cyclohexane oxidation. Hence, a bimetallic 2 wt% Au Cu/Al_(2)O_(3) catalyst was tested in the oxidation of cyclohexane, working at mild conditions of 120 ℃ and 4 bar of O_(2). The combination of the catalyst with a very small amount of benzaldehyde used as cheaper and non-toxic radical initiator allowed to obtain a very high productivity of cyclohexanol and cyclohexanone(45 mmol*m L/mgmet*h) with a selectivity of 94%. Moreover, comparing the catalysed reaction with the non-catalysed one, the role of the catalyst has been disclosed. | Alessandro Vomeri Marta Stucchi Alberto Villa Claudio Evangelisti rea Beck Laura Prati | 2022 | Journal of Energy Chemistry2022，31，7： | 4 |
| 18 | Financial intermediation and growth: Causality and causes显示文摘 | Ross Levine Norman Loayza Thorsten Beck | 2000 | Journal of Monetary Economics2000，，1： | 4 |
| 19 | Stock markets, banks, and growth: Panel evidence显示文摘 | Thorsten Beck Ross Levine | 2002 | Journal of Banking and Finance2002，，3： | 4 |
| 20 | Future impact of integrated high-throughput methylome analyses on human health and disease显示文摘A spate of high-powered genome-wide association studies (GWAS) have recently identified numerous single-nucleotide polymor-phisms (SNPs) robustly linked with complex disease. Despite interrogating the majority of common human variation, these SNPs only account for a small proportion of the phenotypic variance, which suggests genetic factors are acting in concert with non-genetic factors. Although environmental measures are logical covariants for genotype-phenotype investigations, another non-genetic intermediary exists: epigenetics. Epigenetics is the analysis of somatically-acquired and, in some cases, transgenerationally inherited epigenetic modifications that regulate gene expression, and offers to bridge the gap between genetics and environment to understand phenotype. The most widely studied epigenetic mark is DNA methylation. Aberrant methylation at gene promoters is strongly implicated in disease etiology, most notably cancer. This review will highlight the importance of DNA methylation as an epigenetic regulator, outline techniques to character-ize the DNA methylome and present the idea of reverse phenotyping, where multiple layers of analysis are integrated at the individual level to create personalized digital phenotypes and, at a phenotype level, to identify novel molecular signatures of disease. | Lee M Butcher Stephan Beck | 2008 | Journal of Genetics and Genomics2008，35，7： | 3 |
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