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| 1 | Hematopoietic cell transplantation for Crohn’s disease;is it time?显示文摘AIM: To review all studies in the literature that have assessed Hematopoietic cell transplantation (HCT) and Crohn’s disease (CD) with the ultimate aims of determining if this is a viable treatment option for those with CD. A secondary aim was to review the above literature and determine if the studies shed further light on the mechanisms involved in the pathogenesis of CD. METHODS: An extensive Medline search was performed on all articles from 1970 to 2005 using the ; bone marrow transplant, stem cell, hematopoietic cell, Crohn’s disease and inflammatory bowel disease. RESULTS: We identified one case in which a patient developed CD following an allogeneic HCT from a sibling suffering with CD. Evidence for transfer of the genetic predisposition to develop CD was also identified with report of a patient that developed severe CD following an allogeneic HCT. Following HCT it was found that the donor (that had no signs or symptoms of CD) and the recipient had several haplotype mismatches in HLA class Ⅲ genes in the IBD3 locus including a polymorphism of NOD2/CARD15 that has been associated with CD. Thirty three published cases of patients with CD who underwent either autologous or allogeneic HCT were identified. At the time of publication 29 of these 33 patients were considered to be in remission. The median follow-up time was seven years, and twenty months for allogeneic and autologous HCT respectively.For patients who underwent HCT primarily for treatment of their CD there have been no mortalities related to transplant complications. CONCLUSION: Overall these preliminary data suggest that both allogeneic and autologous HCT may be effective in inducing remission in refractory CD. Thissupports the hypothesis that the hematolymphatic cells play a key role in CD and that resetting of the immune system may be a critical approach in the management or cure of CD. | Y Leung M Geddes J Storek R Panaccione PL Beck | 2006 | World Journal of Gastroenterology2006，12，41： | 5 |
| 2 | Second-generation direct-acting-antiviral hepatitis C virus treatment: Efficacy, safety, and predictors of SVR12显示文摘AIM To gather data on the antiviral efficacy and safety of second generation direct acting antiviral(DAA) treatment with respect to sustained virological response(SVR) 12 wk after conclusion of treatment, and to determine predictors of SVR12 in this setting.METHODS Two hundred and sixty patients treated with SOF combination partners PR(n = 51), R(n = 10), SMV(n = 30), DCV(n = 81), LDV(n = 73), or 3D(n = 15).144/260 were pre-treated, 89/260 had liver cirrhosis, 56/260 had portal hypertension with platelets < 100/nL, 25/260 had a MELD score ≥ 10 and 17/260 were postliver transplantation patients. 194/260 had HCV GT1, 44/260 HCV GT3.RESULTS Two hundred and forty/256(93.7%) patients achieved SVR12(m ITT); 4/260 were lost to follow-up. SVR12 rates for subgroups were: 92% for SOF/DCV, 93% for each SOF/SMV, SOF/PR, 94% for SOF/LDV, 100% for 3D, 94% for pretreated, 87% for liver cirrhosis, 82% for patients with platelets < 100/n L, 88% post-liver transplantation, 95% for GT1 a, 93% for GT1 b, 90% for GT3, 100% for GT2, 4, and 6. 12 patients suffered from relapse, 6 prematurely discontinued treatment, of which 4 died. Negative predictors of SVR12 were a platelet count < 100/nL, MELD score ≥ 10(P < 0.0001), liver cirrhosis(P = 0.005) at baseline. In Interferonfree treatment GT3 had significantly lower SVR rates than GT1(P = 0.016). Side effects were mild. CONCLUSION Excellent SVR12 rates and the favorable side-effect profile of DAA-combination therapy can be well translated into 'real-world'. Patients with advanced liver disease, signs of portal hypertension, especially with platelets < 100/n L and patients with GT3 are in special need for further research efforts to overcome comparatively higher rates of virological failure. | Christoph R Werner Julia M Schwarz Daniel P Egetemeyr Robert Beck Nisar P Malek Ulrich M Lauer Christoph P Berg | 2016 | World Journal of Gastroenterology2016，22，35： | 2 |
| 3 | The use of hyperimmune milk to increase longevity显示文摘 | BECK L R | 1993 | International Patent1993，093，： | 2 |
| 4 | New high-performance gel permeation chromatographic system for the determination of low-molecular-weigh amyloses显示文摘 | Praznik W Beck R H F | 1987 | J of Chromatogr1987，387，： | 1 |
| 5 | Finance and sources of growth 显示文摘 | BECK T LEVINE R LOAYZA N 2000 | 2000 | Journal of Financial Economics2000，58，： | 1 |
| 6 | Analysis of estrogenic activity in coastal surface waters of the Baltic Sea using the yeast estrogen screen 显示文摘 | Beck I C Bruhn R Gandrass J | 2006 | Chemosphere2006，63，11： | 1 |
| 7 | Design of driven piles in sand 显示文摘 | Randolph M F Dolwin J Beck R | 1994 | Geotechnique1994，44，3： | 1 |
| 8 | Zur therapie der ozaena 显示文摘 | Beck R Aurbacb C | 1991 | Laryngol RhinolOtol1991，70，： | 1 |
| 9 | Questioning the author 显示文摘 | Beck I McKeown M Hamilton R | 1997 | Newark DE International Reading Association1997，，5： | 1 |
| 10 | The oxidation of aromatic amine in the presence of 'electron-rich' aromatic systems显示文摘 | ZABROWSKI I) L MOORMANN A E BECK K R | 1988 | Tetrahedron Letters1988，29，36： | 1 |
| 11 | Char- acterization of surface oxidation carbon and their influenceon dynamic adsorption显示文摘 | N V Beck S E Meech P R Noman L A Pears | 2001 | Carbon2001，40，4： | 1 |
| 12 | Financial Intermediation and Growth:Causality and Causes 显示文摘 | Levine R Loayza N Beck T | 2000 | Journal of Monetary Economics2000，，01： | 1 |
| 13 | Financial Intermediation and Growth: Causality and Causes 显示文摘 | Levine R Loayza N Beck T | 2000 | Journal of Monetary Economics2000，46，8： | 1 |
| 14 | Influence of virus strain and antigen mass on efficacy of H5 avian influenza inactivated vaccines显示文摘 | Beck J R Garcia M | 1999 | Avian Pathol1999，28，： | 1 |
| 15 | Continuous glucose monitoring and intensive treatment of type 1 diabetes显示文摘 | JUVENILE DIABETES RESEARCH FOUNDATION CONTINUOUS GLUCOSE MONITORING STUDY GROUP TAMBORLANE W V BECK R W | 2008 | N Engl J Med2008，359，14： | 1 |
| 16 | Development of a PCR-based method for identification of Tilletia indica, causal agent of kamal bunt of wheat 显示文摘 | Smith O P Peterson G L Beck R J | 1996 | Phytopathology1996，86，： | 1 |
| 17 | Strategies to improve combustion and emission characteristics of dual fuel pilot ignited natural gas engine 显示文摘 | GEBERT K BECK N J BARKHIMER R L | 1997 | Society of Automotive Engineering Paper1997，，： | 1 |
| 18 | Dyebath Monitoring显示文摘 | Beck K R | 2003 | AATCC Review2003，3，8： | 1 |
| 19 | Elias N computerized acoustic assessment of treatmentefficiency of nebulized epinephrine and albuterol in RSV bronchi-olitis 显示文摘 | Beck R | 2007 | J BMC Pediatr2007，7，1： | 1 |
| 20 | Holmium: YAG lasertripsy for ureteric calculi : an experience of 300 procedures显示文摘 | Devarajan R Ashraf M Beck R O | 1998 | Br J Urol1998，82，3： | 1 |
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