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| 1 | 亚洲首个500kV可控串补(TCSC)工程(Ⅱ)——天广交流输变电平果变电站可控串补控制与保护系统设计方案显示文摘串联补偿广泛应用于增加高电压、长距离和大负荷送电系统的稳定性。电力电子技术的使用使串联补偿具有更大的灵活性与实用性,其优势可以从分2段布置的电容器组中看出来,其中可控串补(TCSC)和固定串补(FSC)设备均放在同一平台上。每段都使用一个独立的旁路断路器来分别将电容器组投入或退出(旁路)。《国际电力》在2004年第4期上介绍了西门子公司承接的中国天广平果站可控串补工程的一次系统设计,本期将介绍该工程的控制与保护系统设计方案。 | K Braun H Spachtholz M Beck 周彦 彭饱书 龚天森 | 2004 | 国际电力2004，8，6： | 8 |
| 2 | Speckle tracking echocardiography to assess regional ventricular function in patients with apical hypertrophic cardiomyopathy显示文摘AIM To explore regional systolic strain of midwall and endocardial segments using speckle tracking echocardiography in patients with apical hypertrophic cardiomyopathy(HCM).METHODS We prospectively assessed 20 patients(mean age 53 ± 16 years,range:18-81 years,10 were male),with apical HCM. We measured global longitudinal peak systolic strain(GLPSS) in the midwall and endocardium of the left ventricle. RESULTS The diastolic thickness of the 4 apical segments was 16.25 ± 2.75 mm. All patients had a normal global systolicfunction with a fractional shortening of 50% ± 8%. In spite of supernormal left ventricular(LV) systolic function,midwall GLPSS was decreased in all patients,more in the apical(-7.3% ±-8.8%) than in basal segments(-15.5% ±-6.93%),while endocardial GLPPS was significantly greater and reached normal values(apical:-22.8% ±-7.8%,basal:-17.9% ±-7.5%). CONCLUSION This study shows that two-dimensional strain was decreased mainly confined to the mesocardium,while endocardium myocardial deformation was preserved in HCM and allowed to identify subclinical LV dysfunction. This transmural heterogeneity in systolic strain had not been previously described in HCM and could be explained by the distribution of myofibrillar disarray in deep myocardial areas. The clinical application of this novel finding may help further understanding of the pathophysiology of HCM. | María Cristina Saccheri Tomás Francisco Cianciulli Luis Alberto Morita Ricardo JoséMéndez Martín Alejandro Beck Juan Enrique Guerra Alberto Cozzarin Luciana Jimena Puente Lorena Romina Balletti Jorge Alberto Lax | 2017 | World Journal of Cardiology2017，9，4： | 7 |
| 3 | Hematopoietic cell transplantation for Crohn’s disease;is it time?显示文摘AIM: To review all studies in the literature that have assessed Hematopoietic cell transplantation (HCT) and Crohn’s disease (CD) with the ultimate aims of determining if this is a viable treatment option for those with CD. A secondary aim was to review the above literature and determine if the studies shed further light on the mechanisms involved in the pathogenesis of CD. METHODS: An extensive Medline search was performed on all articles from 1970 to 2005 using the ; bone marrow transplant, stem cell, hematopoietic cell, Crohn’s disease and inflammatory bowel disease. RESULTS: We identified one case in which a patient developed CD following an allogeneic HCT from a sibling suffering with CD. Evidence for transfer of the genetic predisposition to develop CD was also identified with report of a patient that developed severe CD following an allogeneic HCT. Following HCT it was found that the donor (that had no signs or symptoms of CD) and the recipient had several haplotype mismatches in HLA class Ⅲ genes in the IBD3 locus including a polymorphism of NOD2/CARD15 that has been associated with CD. Thirty three published cases of patients with CD who underwent either autologous or allogeneic HCT were identified. At the time of publication 29 of these 33 patients were considered to be in remission. The median follow-up time was seven years, and twenty months for allogeneic and autologous HCT respectively.For patients who underwent HCT primarily for treatment of their CD there have been no mortalities related to transplant complications. CONCLUSION: Overall these preliminary data suggest that both allogeneic and autologous HCT may be effective in inducing remission in refractory CD. Thissupports the hypothesis that the hematolymphatic cells play a key role in CD and that resetting of the immune system may be a critical approach in the management or cure of CD. | Y Leung M Geddes J Storek R Panaccione PL Beck | 2006 | World Journal of Gastroenterology2006，12，41： | 5 |
| 4 | Future impact of integrated high-throughput methylome analyses on human health and disease显示文摘A spate of high-powered genome-wide association studies (GWAS) have recently identified numerous single-nucleotide polymor-phisms (SNPs) robustly linked with complex disease. Despite interrogating the majority of common human variation, these SNPs only account for a small proportion of the phenotypic variance, which suggests genetic factors are acting in concert with non-genetic factors. Although environmental measures are logical covariants for genotype-phenotype investigations, another non-genetic intermediary exists: epigenetics. Epigenetics is the analysis of somatically-acquired and, in some cases, transgenerationally inherited epigenetic modifications that regulate gene expression, and offers to bridge the gap between genetics and environment to understand phenotype. The most widely studied epigenetic mark is DNA methylation. Aberrant methylation at gene promoters is strongly implicated in disease etiology, most notably cancer. This review will highlight the importance of DNA methylation as an epigenetic regulator, outline techniques to character-ize the DNA methylome and present the idea of reverse phenotyping, where multiple layers of analysis are integrated at the individual level to create personalized digital phenotypes and, at a phenotype level, to identify novel molecular signatures of disease. | Lee M Butcher Stephan Beck | 2008 | Journal of Genetics and Genomics2008，35，7： | 3 |
| 5 | Second-generation direct-acting-antiviral hepatitis C virus treatment: Efficacy, safety, and predictors of SVR12显示文摘AIM To gather data on the antiviral efficacy and safety of second generation direct acting antiviral(DAA) treatment with respect to sustained virological response(SVR) 12 wk after conclusion of treatment, and to determine predictors of SVR12 in this setting.METHODS Two hundred and sixty patients treated with SOF combination partners PR(n = 51), R(n = 10), SMV(n = 30), DCV(n = 81), LDV(n = 73), or 3D(n = 15).144/260 were pre-treated, 89/260 had liver cirrhosis, 56/260 had portal hypertension with platelets < 100/nL, 25/260 had a MELD score ≥ 10 and 17/260 were postliver transplantation patients. 194/260 had HCV GT1, 44/260 HCV GT3.RESULTS Two hundred and forty/256(93.7%) patients achieved SVR12(m ITT); 4/260 were lost to follow-up. SVR12 rates for subgroups were: 92% for SOF/DCV, 93% for each SOF/SMV, SOF/PR, 94% for SOF/LDV, 100% for 3D, 94% for pretreated, 87% for liver cirrhosis, 82% for patients with platelets < 100/n L, 88% post-liver transplantation, 95% for GT1 a, 93% for GT1 b, 90% for GT3, 100% for GT2, 4, and 6. 12 patients suffered from relapse, 6 prematurely discontinued treatment, of which 4 died. Negative predictors of SVR12 were a platelet count < 100/nL, MELD score ≥ 10(P < 0.0001), liver cirrhosis(P = 0.005) at baseline. In Interferonfree treatment GT3 had significantly lower SVR rates than GT1(P = 0.016). Side effects were mild. CONCLUSION Excellent SVR12 rates and the favorable side-effect profile of DAA-combination therapy can be well translated into 'real-world'. Patients with advanced liver disease, signs of portal hypertension, especially with platelets < 100/n L and patients with GT3 are in special need for further research efforts to overcome comparatively higher rates of virological failure. | Christoph R Werner Julia M Schwarz Daniel P Egetemeyr Robert Beck Nisar P Malek Ulrich M Lauer Christoph P Berg | 2016 | World Journal of Gastroenterology2016，22，35： | 2 |
| 6 | Excimer laserassisted recanalisation of feoral arterial stenosis or occusion caused by the use of Angio - Seal显示文摘 | Steinkamp HJ Werk M Beck A | 2001 | Eur Radio2001，11，： | 1 |
| 7 | The squid G onatus fabricii(Lichtenstein),investigations in the Norwegian Sea and the Western Barents Sea,February-September1980and July-September1981显示文摘 | Wiborg K F Gjùster J Beck I M | 1982 | Fisken Havet1982，19，1： | 1 |
| 8 | Acylphosphine oxides as photoiniators for pigmented coatings 显示文摘 | Beck E Keil E Lokaiet M M | 1998 | Modern Paint and Coatings1998，88，3： | 1 |
| 9 | Design of driven piles in sand 显示文摘 | Randolph M F Dolwin J Beck R | 1994 | Geotechnique1994，44，3： | 1 |
| 10 | Multilineage paential of adult human mesenchymal stem cells 显示文摘 | PITFENGER M F MACKAY A M BECK S C | 1999 | Science1999，284，5411： | 1 |
| 11 | Factors affecting efficiency of biomass fermentation to ethanol显示文摘 | Beck M J | 1986 | Biotechnol Bioeng1986，17，： | 1 |
| 12 | Principles and industrial applications of electrical capacitance tomography显示文摘 | Beck M S Byars M Dyakowski T | 1997 | Meas Control1997，30，： | 1 |
| 13 | Hapten-induced model of chronic inflammation and ulceration in the rat colon显示文摘 | MORRIS G P BECK P L HERRIDGE M S | 1989 | Gastrofnterology1989，96，3： | 1 |
| 14 | Questioning the author 显示文摘 | Beck I McKeown M Hamilton R | 1997 | Newark DE International Reading Association1997，，5： | 1 |
| 15 | Multilineage potential of adult human mesenchymal stem cells显示文摘 | Pittenger M F Mackay A M Beck S C | | 0，，5411： | 1 |
| 16 | UP-PCR analysis and ITS1 ribotyping of Trichoderma and Gliocladium fungi显示文摘 | Bulat S A Lübeck M Mironenko N V | 1998 | Mycol Res1998，102，： | 1 |
| 17 | Preven-ting disability in elderly people 显示文摘 | Stuck AE Beck JC Egger M | 2004 | Lancet2004，364，9446： | 1 |
| 18 | Quantitative a- nalysis of cellular inflammation after traumatic spinal cord in- jury : evidence for a multiphasic inflammatory response in the acute to chronic environment显示文摘 | Beck K D Nguyen H X Galvan M D | 2010 | Brain2010，133，2： | 1 |
| 19 | Ordered mesoporous mo- lecular sieves synthesized by a liquid-crystal template mechanism 显示文摘 | Kresge C T Leonowicz M E Beck J S | 1992 | Nature1992，359，6922： | 1 |
| 20 | Reduced prefrontal oxygenation during object and spatial visual working memory in u- nipolar and bipolar depression 显示文摘 | Schecklmanna M Dreslerb T Beck S | 2011 | Psychiatry Research : Neuro- imaging2011，194，3： | 1 |
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