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| 1 | Chemopreventive and Growth Inhibitory Effects of Selenium显示文摘There is very convincing evidence that a high dietary level of selenium substantially reduces the incidence of a wide variety of animal cancers. The human epidemiological evidence is less clear cut, but overall suggests that selenium may be protective: the evidence is strongest in men in relation to gastro-intestinal cancers. There is evidence that dietary selenium compounds reduce the formation of DNA adducts by carcinogens. Selenium compounds also inhibit growth in vitro and induce apoptosis. In general, there is a good correlation between the effectiveness of selenium compounds in chemoprevention and growth inhibition, implying that the mechanisms of growth inhibition and chemoprevention may be similar and that a major factor in the chemopreventive effects of selenium compounds in vivo is their ability to retard outgrowth of pre-malignant cells. Various hypotheses have been advanced as to how selenium compounds might prevent tumour cellgrowth. One is that they cause apoptosis by inducing oxidative stress. However, we have shown that the most potent selenium compound, selenodiglutathione (SDG), a natural metabolite of selenite, does not induce oxidative stress, at least not in the sarne way as other oxidants such as H2O2 and diamide. Firstly, a partially selenium-resistant variant cell line does not show increased resistance to H2O2. Moreover, SDG does not induce widespread tyrosine phosphorylation, including MAP and SAN kinases, like other oxidants such as H2O2 and diamide and its effects are not reversed by pretreatment with the tyrosine kinase inhibitor, herbimycin. Our experiments with the selenium-resistant variant suggest that a novel selenium-binding protein may be involved in growth inhibition by | P. R. HARRISON J. LANFEAR L. WU J. FLEMING L. MCGARRY, AND L. BLOWER (The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road,Bearsden, Glasgow, G61 1BD, Scotland, UK) | 1997 | Biomedical and Environmental Sciences1997，10，2： | 5 |
| 2 | Fast Evaluation of Radial Basis Functions : Methods for Two-Dimensional Polyharmonic Splines 显示文摘 | Beatson R K Light W A | 1997 | IMA Journal of Numerical Analysis1997，17，3： | 1 |
| 3 | Membrane fouling and its control in environmental applications显示文摘 | Fane A G Beatson P Li H | 2000 | Water Sci Technol2000，41，1011： | 1 |
| 4 | An extensive reper- toire of type Ⅲ secretion effectors in Escherichia coli Ols7 and the role of lambdoid phages in their dissemination显示文摘 | Tobe T Beatson S A Taniguchi H | 2006 | Proceed- ings of the National Academy of Sciences of the United States of America2006，103，14： | 1 |
| 5 | Surface interpolation with radial basis functions for medical imaging显示文摘 | CARR J C FRIGHT W BEATSON R K | 1997 | IEEE Transactions on Medical Imaging1997，16，1： | 1 |
| 6 | Fast evaluation ofpolyharmonic splines in three dimensions显示文摘 | Beatson R K Powell M J D Tan A M | 2006 | IMA Jour-nal of Numerical Analysis2006，27，3： | 1 |
| 7 | On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment, with illustrativecases 显示文摘 | Beatson GT | | Lancet0，2，： | 1 |
| 8 | Smooth fitting of geophysical data using continuous global surfaces 显示文摘 | BILLINGS S D NEWSAM G N BEATSON R K | 2002 | Geophysics2002，67，6： | 1 |
| 9 | Fast solution of the radial basis function interpolation equations:domain decomposition methods显示文摘 | Beatson R K Light R K Billings S | 2000 | SIAM Sci Comput2000，22，5： | 1 |
| 10 | Accumulation of specific dissolved and colloidal substances during white water recycling affect paper properties显示文摘 | Zhang X Beatson R P Cal Y J | 1999 | JPPS1999，25，6： | 1 |
| 11 | Identification of type n and type III pyoverdine receptors from Pseudomonas aeruginosa 显示文摘 | Chial M Ghysels B Beatson S A | 2003 | Microbiology2003，149，4： | 1 |
| 12 | Salmonellae isolated from domestic meat waste 显示文摘 | Durrant DS and Beatson SH | 1981 | J Hyg( Lond)1981，86，： | 1 |
| 13 | AninvestigationL study of nucLeus puLposus repLacement using an insitu curabLe poLyurethane:an invivo non-human private modeL显示文摘 | Cunningham B Hu N Beatson H | 2007 | Spine J2007，7，5： | 1 |
| 14 | Identification of type Ⅱ and type Ⅲ pyoverdine receptors from Pseudomonas aeruginosa显示文摘 | DE CHIAL M GHYSELS B BEATSON S A | 2003 | Microbiology2003，149，： | 1 |
| 15 | Better bases for radial ba- sis function interpolation problems显示文摘 | Beatson R K Levesley J Mouat C T | 2011 | Journal of Computational and Applied Mathematics2011，236，4： | 1 |
| 16 | Differential regulation of twitching motility and elastase production by Vfr in Pseudomonas aeruginosa显示文摘 | Beatson S A Whitchurch C B Sargent J L | 2002 | J Bacteriol2002，184，13： | 1 |
| 17 | Identification of type Ⅱ and type Ⅲ pyoverdine receptors from Pseudo monas aeruginosa 显示文摘 | de Chial M Ghysels B Beatson S A | 2003 | Microbiology2003，149，4： | 1 |
| 18 | Univariate multiquadric approximation: Quasi-interpolation to scattered data显示文摘 | R. K. Beatson M. J. D. Powell | 1992 | Constructive Approximation1992，，3： | 1 |
| 19 | Fast evaluation of radial basis functions:methods for two-dimensional polyharmonic splines显示文摘 | BEATSON R K LIGHT W A | 1997 | IMA Journal of Numerical Analysis1997，17，3： | 1 |
| 20 | Inter- ventional radiology in acute pancreatitis: friend or foe? 显示文摘 | KHQRSANDI M BEATSON K DQUGHERTY S | 2012 | JOP2012，13，1： | 1 |
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