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| 1 | Taking advantage of the potential of mesenchymal stromal cells in liver regeneration:Cells and extracellular vesicles as therapeutic strategies显示文摘Cell-based therapies for acute and chronic liver diseases are under continuous progress. Mesenchymal stem/stromal cells(MSCs) are multipotent cells able to migrate selectively to damaged tissue and contribute to its healing and regeneration. The MSC pro-regenerative effect occurs due to their immunomodulatory capacity and their ability to produce factors that promote cell protection and survival. Likewise,it has been observed that part of their paracrine effect is mediated by MSC-derived extracellular vesicles(EVs). EVs contain proteins,lipids and nucleic acids(DNA,m RNA,mi RNA,lnc RNA) from the cell of origin,allowing for intercellular communication. Recently,different studies have demonstrated that MSC-derived EVs could reproduce,at least in part,the biological effects obtained by MSCbased therapies. Moreover,due to EVs' stability for long periods of time and easy isolation methods they have become a therapeutic option to MSCs treatments. This review summarizes the latest results achieved in clinical trials using MSCs as cell therapy for liver regeneration,the role of EVs in liver physiopathology and the potential of MSC-derived EVs as intercellular mediators and therapeutic tools in liver diseases. | Esteban Juan Fiore Luciana María Domínguez Juan Bayo Mariana Gabriela García Guillermo Daniel Mazzolini | 2018 | World Journal of Gastroenterology2018，24，23： | 9 |
| 2 | Therapeutic efficacy and effects of artemisinin-based combination treatments on uncomplicated Plasmodium falciparum malaria-associated anaemia in Nigerian children during seven years of adoption as first-line treatments显示文摘Background:Artemisinin-based combination treatments(ACTs)are the first-line treatments of uncomplicated Plasmodium falciparum malaria in many endemic areas but there are few evaluation of their efficacy in anaemic malarious children.Methods:Therapeutic efficacy of 3-day regimens of artesunate-amodiaquine and artemether-lumefantrine was evaluated in 437 anaemic and 909 non-anaemic malarious children following treatment during a seven-year period(2008-2014).Patterns of temporal changes in haematocrit were classified based on haematocrit values<30%and≥30%.Kinetics of the disposition of the deficit in haematocrit from 30%following treatment were evaluated using a non-compartment model.Results:PCR-corrected parasitological efficacy 28 days after start of treatment was significantly higher in artesunateamodiaquine-compared to artemether-lumefantrine-treated children[97%(95%CI:92.8-100)versus 96.4%(95%CI:91.3-99.4),P=0.02],but it was similar in non-anaemic and anaemic children.Fall in haematocrit/1000 asexual parasites cleared from peripheral blood was significantly greater at lower compared to higher parasitaemias(P<0.0001),and in non-anaemic compared to anaemic children(P=0.007).In anaemic children at presentation,mean anaemia recovery time(AnRT)was 15.4 days(95%CI:13.3-17.4)and it did not change over the years.Declines in haematocrit deficits from 30%were monoexponential with mean estimated half-time of 1.4 days(95%CI:1.2-1.6).Anaemia half-time(t_(1/2anaemia))correlated positively with AnRT in the same patients(r=0.69,P<0.0001).Bland-Altman analysis of 10 multiples of t_(1/2anaemia) and AnRT showed narrow limit of agreement with insignificant bias(P=0.07)suggesting both can be used interchangeably in the same patients.Conclusions:Artesunate-amodiaquine and artemether-lumefantrine remain efficacious treatments of uncomplicated P.falciparum infections in non-anaemic and anaemic Nigerian children in the last 7 years of adoption as first-line treatments.These ACTs may also conserve haematocrit at high parasitaemias and in anaemic children.Trials registration:Pan African Clinical Trial Registry PACTR201508001188143,3 July 2015;PACTR201510001189370,3 July 2015;PACTR201508001191898,7 July 2015 and PACTR201508001193368,8 July 2015. | Akintunde Sowunmi Kazeem Akano Godwin Ntadom Adejumoke I.Ayede Folasade O.Ibironke Temitope Aderoyeje Elsie O.Adewoye Bayo Fatunmbi Stephen Oguche Henrietta U.Okafor Ismaila Watila Martin Meremikwu Philip Agomo William Ogala Chimere Agomo Onikepe A.Folarin Grace O.Gbotosho Christian T.Happi | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 3 | Accuracy of discrete models for the solution of the inverse dynamics problem for flexible arms, feasible trajectories 显示文摘 | H C Moulin E Bayo | 1997 | ASME Journal of Dynamic Systems Measurement and Control (S0022-0434)1997，119，9： | 1 |
| 4 | Single low-dose cyclophos- phamide combined with interleukin-12 gene therapy is superior to a metronomic schedule in inducing immunity against colorectalcarcinoma in mice显示文摘 | Malvicini M Alaniz L Bayo J | 2011 | Oncoimmunology2011，1，7： | 1 |
| 5 | Ecotoxicological screening of reclaimed disinfected wastewater by Vibrio fischeri bioassay after a chlorination-dechlorination process显示文摘 | Javier Bayo José M Angosto M Dolores Gómez-López | | 0，，01： | 1 |
| 6 | Inverse dynamics of flexible manipulators withCoulomb friction and backlash and non-zero initial conditions 显示文摘 | T A Trautt E Bayo | 1999 | Dynamics and Control (S0925-4668)1999，9，2： | 1 |
| 7 | Development of practical design methods for steel structures with semi-rigid connections 显示文摘 | Cabrero J M Bayo E | 2005 | Engineering Structures2005，，7： | 1 |
| 8 | On trajectory generation for flexible robots显示文摘 | Bayo E Paden B | 1987 | Journal of Robotic Systems1987，4，2： | 1 |
| 9 | Hepatocellular carcinoma cells and their fibrotic microenvironment modulate bone man, ow - de- rived mesenchymalstromal cell migration in vitro and in vivo 显示文摘 | Garcia MG Bayo J Bolontrade MF | 2011 | Mol Pharm2011，8，5： | 1 |
| 10 | Use of special ritz vectors in dynamic substructure analysis 显示文摘 | Wilson E L Bayo E P | 1967 | AIAA Journal1967，5，7： | 1 |
| 11 | Chemoimmunotherapy for advanced gastrointestinal carcinomas:A successful combination of gene therapy and cyclophosphamide显示文摘 | MALVICINI M PICCIONI F BAYO J | 2012 | Oncoimmunology2012，1，9： | 1 |
| 12 | Glucocorticoid receptor is required for skin barrier competence显示文摘 | Bayo P Sanchis A Bravo A | 2008 | Endocrinology2008，149，3： | 1 |
| 13 | Singularity-free augmented Lagrangian algorithms for constrained multibody dynamics显示文摘 | Bayo E Avello A | | 0，，： | 1 |
| 14 | Endoscopic ure- terectomy显示文摘 | Valdivia Uria JG Lopez Lopez JA Bayo Ochoa A | 1991 | Arch Esp Urol1991，44，5： | 1 |
| 15 | Augmented lagrangian and mass-orthogonal projection methods for constrained multibody dynamics显示文摘 | Bayo E Ledesma R | | 0，，： | 1 |
| 16 | Modeling and solution methods for efficient real-time simulation of multibody dynamics显示文摘 | CUADRADO J CARDENAL J BAYO E | 1997 | Multibody System Dynamics1997，，1： | 1 |
| 17 | Development of practical design methods for steel structures with semi-rigid connections 显示文摘 | Cabrecro J M Bayo E | 2005 | Engineering Structures2005，27，8： | 1 |
| 18 | An effective component-based method to model semi-rigid connections for the global analysis of steel and composite structures,显示文摘 | BAYO E CABRERI J M GIL B | 2006 | Engineering Structures2006，28，： | 1 |
| 19 | Use of Ritz vectors in wave propagation and foundation response显示文摘 | BAYO E WILSON E L | 1984 | Earthquake Engineering and Structural Dynamics1984，12，： | 1 |
| 20 | Loss of SOX2 expression induces cell motility via vimentin up-regulation and is an unfavorable risk factor for survival of head and neck squamous cel carcinoma显示文摘 | Bayo P Jou A Stenzinger A Shao C Gross M Jensen A | 2015 | Mol Oncol2015，9，8： | 1 |
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