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| 1 | 以青蒿素类化合物为基础的抗疟联合疗法研究进展显示文摘疟疾是一种严重危及生命的传染病,对人类生活产生着深远影响。青蒿素至今仍是世界卫生组织推荐的临床抗疟一线用药,其抗疟活性主要体现在过氧桥结构上。以青蒿素类化合物为基础的联合疗法(ACT)是多国治疗疟疾的一线方法,主要包括蒿甲醚-本芴醇、青蒿琥酯-阿莫地喹和双氢青蒿素-哌喹等。相较于青蒿素单一疗法,ACT具有缩短患者住院时间、加快寄生虫清除速度、节约经济成本等优势,但目前存在耐药性等问题。本文对近年来国内外有关ACT的应用现状及优缺点作一综述,以期为后续筛选ACT中的长效辅助抗疟药物、解决耐药性问题提供思路。 | 严莹莹 张会敏 李晓晶 杨宗统 隋在云 | 2022 | 中国药房2022，33，15： | 2 |
| 2 | Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children显示文摘Background:In acute falciparum malaria,asexual parasite reduction ratio two days post-treatment initiation(PRRD2)≥10000 per cycle has been used as a measure of the rapid clearance of parasitaemia and efficacy of artemisinin derivatives.However,there is little evaluation of alternative measures;for example,parasite reduction ratio one day after treatment initiation(PRRD1)and its relationship with parasite clearance time(PCT)or PRRD2.This study evaluated the use of PRRD1 as a measure of responsiveness to antimalarial drugs.Methods:In acutely malarious children treated with artesunate-amodiaquine(AA),artemether-lumefantrine(AL)or dihydroartemisinin-piperaquine(DHP),the relationships between PRRD1 or PRRD2 and PCT,and between PRRD1 and PRRD2 were evaluated using linear regression.Agreement between estimates of PCT using PRRD1 and PRRD2 linear regression equations was evaluated using the Bland-Altman analysis.Predictors of PRRD1>5000 per half cycle and PRRD2≥10000 per cycle were evaluated using stepwise multiple logistic regression models.Using the linear regression equation of the relationship between PRRD1 and PCT previously generated in half of the DHP-treated children during the early study phase,PCT estimates were compared in a prospective blinded manner with PCTs determined by microscopy during the later study phase in the remaining half.Results:In 919 malarious children,PRRD1 was significantly higher in DHP-and AA-treated compared with AL-treated children(P<0.0001).PRRD1 or PRRD2 values correlated significantly negatively with PCT values(P<0.0001 for each)and significantly positively with each other(P<0.0001).PCT estimates from linear regression equations for PRRD1 and PRRD2 showed insignificant bias on the Bland-Altman plot(P=0.7)indicating the estimates can be used interchangeably.At presentation,age>15months,parasitaemia>10000/μl and DHP treatment independently predicted PRRD1>5000 per half cycle,while age>30months,haematocrit≥31%,body temperature>37.4°C,parasitaemia>100000/μl,PRRD1 value>1000 and no gametocytaemia independently predicted PRRD2≥10000 per cycle.Using the linear regression equation generated during the early phase in 166 DHP-treated children,PCT estimates and PCTs determined by microscopy in the 155 children in the later phase were similar in the same patients.Conclusions:PRRD1 and estimates of PCT using PRRD1 linear regression equation of PRRD1 and PCT can be used in therapeutic efficacy studies.Trial registration:Pan African Clinical Trial Registration PACTR201709002064150,1 March 2017,http://gffzzfa6f54609a9647a4hc5nb6bpc9bnf6xvv.ffgz.tsg.suse.edu.cn. | Kazeem Akano Godwin Ntadom Chimere Agomo Christian T.Happi Onikepe A.Folarin Grace O.Gbotosho Olugbenga Mokuolu Finomo Finomo Joy C.Ebenebe Nma Jiya Jose Ambe Robinson Wammanda George Emechebe Oluwabunmi K.Basorun Olubunmi A.Wewe Sikiru Amoo Nnenna Ezeigwe Stephen Oguche Bayo Fatunmbi Akintunde Sowunmi | 2018 | Infectious Diseases of Poverty2018，7，1： | 0 |
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