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| 1 | Novel role for gabapentin in neuroprotection of central nervous system in streptozotocine-induced diabetic rats显示文摘Aim: To investigate the effect of gabapentin on neural [neuron-specific enolase (NSE)] and glial markers [glial fibrillary acidic protein (GFAP) and S 100B] in different brain regions of diabetic rats. Methods: Diabetes was induced by a single intraperitoneal injection of streptozotocine (50mg/kg body weight). Rats in one diabetic group received gabapentin (50mg·kg^-1·d^-1) and rats in the other diabetic group received vehicle only for 6 weeks. The levels of GFAP, S100B, and NSE were determined by immunoblotting in the hippocampus, cortex, and cerebellum. Lipid peroxidation (LPO as malondialdehyde+4-hydroxyalkenals) and glutathione (GSH) levels were also determined in the same brain parts. Results: Total and degraded GFAP content and S100B protein expression in different areas of brain tissues significantly increased in diabetic rats compared to control rats. Similarly, NSE levels were also significantly elevated in hyperglycemic rats. In addition, there was a significant increase in LPO levels in the diabetic rat brain compared to control rat brains. Pretreatment with gabapentin prevented the upregulation of GFAP, S 100B, and NSE in all brain regions of diabetic rats. The level of LPO was reduced, but not completely halted, by treatment with gabapentin. Conclusion:These results suggest that diabetes causes glial and neuronal injury, possibly as a result of elevated oxidative stress, and that gabapentin protects neurons and glial cells. Thus, we predict that gabapentin treatment will attenuate the hippocampal and cortical neurodegeneration observed during diabetes mellitus in rats. | Giyasettin BAYDAS Ertugrul SONKAYA Mehmet TUZCU Abdullah YASAR Emir DONDER | 2005 | Acta Pharmacologica Sinica2005，26，4： | 5 |
| 2 | Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin-induced diabetes mellitus显示文摘 | Giyasettin Baydas Halit Canatan Abdulbaki Turkoglu | 2002 | Journal of Pineal Research2002，324，： | 1 |
| 3 | Protective effects of melation in against ethanol induced reactive gliosis in hippocampus and cortex of young and aged rats显示文摘 | Baydas G Tuzcu M | 2005 | Exp Neurol2005，194，1： | 1 |
| 4 | Effects of melatonin and vitamin E on diabe- tes- induced learning and impairment in rats 显示文摘 | TUZCU M BAYDAS G | 2006 | Eur Pharmacol2006，537，13： | 1 |
| 5 | Inhibitory effects of melatonin on neural lipidperoxidation induced by intraeerebroventricularly administered homoeysteine显示文摘 | Baydas G | 2003 | J Pineal Res2003，34，1： | 1 |
| 6 | Melatonin reduces glial reactivity in the hippocarnpus, cortex, and cerebellum of streptozotocin- induced diabetic rats 显示文摘 | Baydas G Reirer R J YaserA | 2003 | Free Radic Biol Med2003，35，7： | 1 |
| 7 | Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin-induced diabetes mellitus显示文摘 | Baydas G Canatan H Turkoglu A | 2002 | J Pineal Res2002，32，2： | 1 |
| 8 | Effects of resveratrol on blood homocysteine level,on homocysteine induced ox- idative stress,apoptosis and cognitive dysfunctions in rats 显示文摘 | Koz ST Etem EO Baydas G | 2012 | Brain Res2012，1484，： | 1 |
| 9 | Credit Rationing in Small-semle Enterprises: Special Microenterprise Programmes in Ecuador显示文摘 | Baydas M M R L Meyer N Aguilera-alfred | 1994 | The Journal of Development1994，31，： | 1 |
| 10 | Protective effects of melatonin against ethanol-induced reactive gliosis in hippocampus and cortex of young and aged rats显示文摘 | Baydas G Tuzcu M | | 0，，01： | 1 |
| 11 | Informal Finance in Egypt 'Banks'within Banks显示文摘 | BAYDAS M M BAHLOUL Z ADAMS D W | 1995 | World Development1995，，4： | 1 |
| 12 | Credit ra- tioningin small-scale enterprises:Special micro-enterprise prgrammes in ecuador 显示文摘 | Baydas M M Meyer R L Aguilera -Alfred N | 1994 | Journal of Development Stud- ies1994，31，2： | 1 |
| 13 | Effects of lamotrigine and topiramate on brain maturation and cognitive functions in offspring of pregnant rats-preliminary study显示文摘 | Dag E Dag ZO Baydas G | 2014 | Adv Clin Exp Med2014，23，5： | 1 |
| 14 | Credit rationing in small-scale enterprises: Special microenterprise programmes in ecuador显示文摘 | Mayada M. Baydas Richard L. Meyer Nelson Aguilera-Alfred | 1994 | Journal of Development Studies1994，，2： | 1 |
| 15 | Effects of early loss of permanent first molars on the development of third molars 显示文摘 | Yavuz I Bayda B Ikbal A | 2006 | Am J Orthod Dento facial Orthop2006，130，5： | 1 |
| 16 | Antioxidant vitamin levels in term and preterm infants and their relation to maternal vitamin status 显示文摘 | BAYDAS G KARATAS F GURSU M F | 2002 | Archives of Medical Research2002，33，3： | 1 |
| 17 | Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin induced diabetes mellitus 显示文摘 | Baydas G Canatan H Turkoglu A | 2002 | J Pineal Res2002，32，4： | 1 |
| 18 | Protective effects of melatonin against ethanol-in-duced reactive gliosis in hippocampus and cortex of young and aged rats显示文摘 | Baydas G Tuzcu M | 2005 | Exp Neurol2005，194，1： | 1 |
| 19 | A novel role for melatonin:regulation of the expression of cell adhesion molecules in the rat hippocampus and cortex显示文摘 | Baydas G Nedzvetsky VS Nerush PA | 2002 | Neurosci Lett2002，326，2： | 1 |
| 20 | Melatonin inhibits neural ap- optosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro-and anti-apoptotic protein levels显示文摘 | Baydas G Reiter R J Akbulut M | 2005 | Neuroscience2005，135，3： | 1 |
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