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| 1 | Management of inflammatory bowel disease with Clostridium difficile infection显示文摘AIM To address the management of Clostridium difficile(C. difficile) infection(CDI) in the setting of suspected inflammatory bowel disease(IBD)-flare.METHODS A systematic search of the Ovid MEDLINE and EMBASE databases by independent reviewers identified 70 articles including a total of 932141 IBD patients or IBDrelated hospitalizations. RESULTS In those with IBD,CDI is associated with increased morbidity,including subsequent escalation in IBD medical therapy,urgent colectomy and increased hospitalization,as well as excess mortality. Vancomycincontaining regimens are effective first-line therapies for CDI in IBD inpatients. No prospective data exists with regards to the safety or efficacy of initiating or maintaining corticosteroid,immunomodulator,or biologic therapy to treat IBD in the setting of CDI. Corticosteroid use is a risk factor for the development of CDI,while immunomodulators and biologics are not. CONCLUSION Strong recommendations regarding when to initiate IBD specific therapy in those with CDI are precluded by a lack of evidence. However,based on expert opinion and observational data,initiation or resumption of immunosuppressive therapy after 48-72 h of targeted antibiotic treatment for CDI may be considered. | Julie D’Aoust Robert Battat Talat Bessissow | 2017 | World Journal of Gastroenterology2017，23，27： | 14 |
| 2 | Transcriptome and Metabolic Profiling Provides Insigh into Betalain Biosynthesis and Evolution in Mirabilis jalapa显示文摘 | Guy Polturak Uwe Heinig Noam Grossman Maor Battat Dena Leshkowitz Sergey Malitsky liana Rogachev~ and Asaph Aharoni | 2018 | Molecular Plant2018，11，1： | 10 |
| 3 | Co-existence of non-alcoholic fatty liver disease and inflammatory bowel disease: a review article显示文摘Emerging data have highlighted the co-existence of nonalcoholic fatty liver disease(NAFLD) and inflammatory bowel disease; both of which are increasingly prevalent disorders with significant complications and impact on future health burden. Cross-section observational studies have shown widely variable prevalence rates of co-existing disease,largely due to differences in disease definition and diagnostic tools utilised in the studies. Age,obesity,insulin resistance and other metabolic conditions are common risks factors in observational studies. However,other studies have also suggested a more dominant role of inflammatory bowel disease related factors such as disease activity,duration,steroid use and prior surgical intervention,in the development of NAFLD. This suggests a potentially more complex pathogenesis and relationship between the two diseases which may be contributed by factors including altered intestinal permeability,gut dysbiosis and chronic inflammatory response. Commonly used immunomodulation agents pose potential hepatic toxicity,however no definitive evidence exist linking them to the development of hepatic steatosis,nor are there any data on the impact of therapy and prognosis in patient with co-existent diseases. Further studies are required to assess the impact and establish appropriate screening and management strategies in order to allow early identification,intervention and improve patient outcomes. | Che-yung Chao Robert Battat Alex Al Khoury Sophie Restellini Giada Sebastiani Talat Bessissow | 2016 | World Journal of Gastroenterology2016，22，34： | 7 |
| 4 | Machine learning models and over-fitting considerations显示文摘Machine learning models may outperform traditional statistical regression algorithms for predicting clinical outcomes.Proper validation of building such models and tuning their underlying algorithms is necessary to avoid over-fitting and poor generalizability,which smaller datasets can be more prone to.In an effort to educate readers interested in artificial intelligence and model-building based on machine-learning algorithms,we outline important details on crossvalidation techniques that can enhance the performance and generalizability of such models. | Paris Charilaou Robert Battat | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 5 | Optimization of L-malic acid production by Aspergillus flavus in a stirred fementor显示文摘 | BATTAT E PELEG Y BERCOVITZ A | 1991 | Biotechnology and Bioengineering1991，37，： | 1 |
| 6 | Improving safety and operational efficiency in residential care settings with wifi - based localization 显示文摘 | Doshi -Velez F Li W Battat Y | 2012 | J Am Med Dir Assoc2012，13，6： | 1 |
| 7 | Global health competenciesand approaches in medical education: a literature review 显示文摘 | Battat R Seidman G Chadi N | 2010 | BMCMed Educ2010，10，： | 1 |
| 8 | Global health competencies and approaches in medical education:a literature review显示文摘 | Battat R Seidman G Chadi N | 2010 | BMC Med Educ2010，，10： | 1 |
| 9 | Optimization of a medium for a high yield production of spore-crystal preparation of Bacillus thuringieusis effective against the Egyptian cotton leaf worm Spodoptera littoralis Boisd显示文摘 | Goldberg I Sneh B Battat E | 1980 | Biotechnology Letters1980，2，10： | 1 |
| 10 | Effects of laser in situ keratomileusis on tear production, clearance and the ocular surface 显示文摘 | Battat L Macri A Darsun D | 2001 | Ophthalmology2001，108，7： | 1 |
| 11 | Effects of laser in situ ker- atomileusis on tear production, clearance, and the ocular surface 显示文摘 | Battat L Macri A Dursun D | 2001 | Ophthalmology2001，108，7： | 1 |
| 12 | Patterns of opioid consumption in cancer patients显示文摘 | Freud T Sherf M Battat E | | 0，，02： | 1 |
| 13 | Effects of laser in situ keratomileuses on tears production,clearance,and the ocular surface显示文摘 | Battat L Macri A Dursun D Pflugfelder SC | | 0，，7： | 1 |
| 14 | Optimization of L-malic acid production by Aspergiulls flavus in a stirried fermentor显示文摘 | Battat E Peleg Y Bercovitz A | 1991 | Biotechnol Bioeng1991，27，： | 1 |
| 15 | Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface显示文摘 | Battat L Macri A Dursun D | 2001 | Ophthalmology2001，108，7： | 1 |
| 16 | Effects of laser in situ keratomileusis on tearproduction, clearance, and theocularsurface显示文摘 | Battat L Macri A Dursun D | 2001 | Ophthalmology2001，108，： | 1 |
| 17 | Optimization of L- malic acid production by Aspergillus flavus in a stirred fer- mentor 显示文摘 | Battat E Peleg Y Bercovitz A | 1991 | Biotechnology and Bioengineering1991，37，11： | 1 |
| 18 | PUVA bath therapy strongly suppresses immunological and epidermal activation in psoriasis:a possible cellular basis for remittive therapy显示文摘 | VALLAT V P GILLEAUDEAU P BATTAT L | 1994 | J Exp Med1994，180，1： | 1 |
| 19 | Continuous culture used for media optimization显示文摘 | MATELES R I BATTAT E | 1974 | Appl Microbiol1974，28，6： | 1 |
| 20 | Effects of laser in situ keratomileusis On tear production,clearance and the ocular surface显示文摘 | Battat L Macri A Dursun D | 2001 | Ophthalmology2001，108，7： | 1 |
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