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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Nasal polyps:still more questions than answers显示文摘 | BATEMAN N D FAHY C WOOLFORD T J | 2003 | J Laryngol Otol2003，117，： | 1 |
| 3 | Evaluation of Ruminally Protected Methionine and Lysine or Blood Meal and Fishmeal as Protein Sources for Lactating Holsteins显示文摘 | Bateman H D Spain J N Kerley M S | 1999 | J Dairy Sci1999，82，8： | 1 |
| 4 | Evaluation of ruminally protected methionine and lysine or blood meal and fish meal as protein sources for lactating Holsteins显示文摘 | Bateman H D Spain J N Kerley M S | 1999 | J Dairy Sci1999，82，： | 1 |
| 5 | Presentation of first branchial cleft anomalies:the Sheffield experience显示文摘 | Martinez Del Pero M Majumdar S Bateman N | 2007 | Laryngol Otol2007，121，5： | 1 |
| 6 | The Pfam protein families database 显示文摘 | Punta M Coggill P C Eberhardt R Y Mistry J Tate J Boursnell C Pang N Forslund K Ceric G Clements J Hcger A Holm L Sonnhammer E L Eddy S R Bateman A Finn R D | 2012 | Nucleic Acids Research2012，40，： | 1 |
| 7 | Evaluation of ruminally protected methionine and lysine or blood meal and fishmeal as protein sources for lactating Holsteins显示文摘 | Bateman H D Spain J N Kerley M S | 1999 | Dairy Sci1999，82，： | 1 |
| 8 | Extrapyramidal reactions with metoclopramide 显示文摘 | D N Bateman M D Rawlins and J M Simpson | 1985 | Br Med J (Clin Res Ed )1985，5291，： | 1 |
| 9 | Evaluation of ruminally protected methionine and lysine or blood meal and fish meal as protein sources for lactating Holsteins显示文摘 | Spain J N Kerley M S Belyea R L and Marshall R T | 1999 | J Dairy Sci1999，82，： | 1 |
| 10 | Nasal polyps; still more question than answer显示文摘 | BATEMAN N D FAHY C WOOLFORD T J | 2003 | Laryngol Otol2003，117，： | 1 |
| 11 | Principles of crown lengthening surgery显示文摘 | Bateman GJ Karir N Saha S | 2009 | Dent Update2009，36，3： | 1 |
| 12 | Evaluation of ruminally protected methionine and lysine or blood meal and fish meal as protein sources for lactating Holsteins显示文摘 | Bateman H G Spain J N Kerley M S | 1999 | J Dairy Sci1999，82，10： | 1 |
| 13 | MEROPS: thepeptidase database显示文摘 | Rawlings N D Barrett A J Bateman A | 2010 | Nucleic Acids Res2010，38，： | 1 |
| 14 | Electr ocardi ogram and cardiovascular changes in thi oridazine and chlor p r omazine pois oning显示文摘 | Strachan E M Kelly C A Bateman D N | 2004 | Clin Pharmacol2004，60，： | 1 |
| 15 | Nasal polyps:still more questions than answers显示文摘 | BATEMAN N D FAHY C WOOLFORD T J | 2003 | J Laryngol Otol2003，117，： | 1 |
| 16 | Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain显示文摘 | Cerutti L Mian N Bateman A | 2000 | Trends Biochem Sci2000，25，： | 1 |
| 17 | Principles of crown lengthe-ning sur-gery显示文摘 | Bateman GJ Karir N Saha S | 2009 | Dent Update2009，36，3： | 1 |
| 18 | Use of a beryllium Hopkinson bar to characterize a piezoresistive aecelerom- eter in shock environments显示文摘 | Bateman V I Brown F A Davie N T | 1996 | Journal of the Institute of Environmental Sciences1996，39，6： | 1 |
| 19 | Nasal polyps:still more questions than answers显示文摘 | BATEMAN N D FAHY C WOOLFORD T J | 2003 | J Laryngol Otol2003，117，： | 1 |
| 20 | Intestinal tumor progression is associated with altered function of KLF5显示文摘 | BATEMAN N M TAN D PESTELL R G | | 0，，13： | 1 |
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