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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Influence of vascular endothelial growth factor single nucleotide polymorphisms on tumour development in cutaneous malignant melanoma显示文摘 | HOWELL W M BATEMAN A C TURNER S J | 2002 | Hums Immun2002，3，： | 1 |
| 3 | Osteoprotegerin mitigates tail suspension-induced osteopenia显示文摘 | Bateman T A Dunstan C R Ferguson V L et al | 2000 | Bone2000，，26： | 1 |
| 4 | Computer simulation of the impact performance of a wire rope safety fence显示文摘 | Bateman M B Howard I C Johnson A R | | 0，，1： | 1 |
| 5 | Mucosal expression of cyclooxygenase isoforms 1 and 2 is increased with worsening damage to the gastric mucosa显示文摘 | A C Bateman R L Mehta | 2005 | Histopathology2005，46，3： | 1 |
| 6 | The G5 domain: a potentialN-acetylglucosamine recognition domain involved in biofilmformation显示文摘 | Bateman A Holden M T Yeats C | 2005 | Bioinformatics2005，21，8： | 1 |
| 7 | The independent predictive utility of computed tomography angiographic collateral status in acute ischaemic stroke显示文摘 | Miteff F Levi C R Bateman G A | 2009 | Brain2009，132，8： | 1 |
| 8 | The independent predictive utility of computed tomography angiographic collateral status in acute ischaemic stroke显示文摘 | MITEFF F LEVI C R BATEMAN G A | 2009 | Brain2009，132，8： | 1 |
| 9 | The independent predictive utility of computed tomography angiographic collateral status in acute ischaemic stroke显示文摘 | MITEFF F LEVI C R BATEMAN G A | 2009 | Brain2009，132，8： | 1 |
| 10 | The Pfam protein families database 显示文摘 | Punta M Coggill P C Eberhardt R Y Mistry J Tate J Boursnell C Pang N Forslund K Ceric G Clements J Hcger A Holm L Sonnhammer E L Eddy S R Bateman A Finn R D | 2012 | Nucleic Acids Research2012，40，： | 1 |
| 11 | Reduction of image noise in low tube current dynamic CT myocardial perfusion iraaging using HYPR processing: a time-attenuation curve analysis 显示文摘 | SPEIDEL M A BATEMAN C L TAO Y | 2013 | MedPhys2013，40，01： | 1 |
| 12 | Gene therapy for pro-state cancer: current status and future prospects显示文摘 | Harrington K J Spitzweg C Bateman A R | 2001 | J Urol2001，166，： | 1 |
| 13 | Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease显示文摘 | Banks C Bateman A Payne R | 2003 | J Pathol2003，199，2： | 1 |
| 14 | Fibronectin type IQ domains in yeast detected by a hidden Markov model显示文摘 | Bateman A Chothia C | 1996 | Curr Biol1996，6，12： | 1 |
| 15 | Electr ocardi ogram and cardiovascular changes in thi oridazine and chlor p r omazine pois oning显示文摘 | Strachan E M Kelly C A Bateman D N | 2004 | Clin Pharmacol2004，60，： | 1 |
| 16 | The independent predictive utility of computed tomography angiographic collateral status in acute ischaemic stroke显示文摘 | MITEFF F LEVI C R BATEMAN G A | 2009 | Brain2009，132，8： | 1 |
| 17 | Immunohistochemi-Cal phenotype of malignant mesothelioma : predictive value of CA125 And HBME-I expression 显示文摘 | Bateman A C al-Talib R K New man T | 1997 | Histopathology1997，30，1： | 1 |
| 18 | Mechanism for the role of magnesia in the sintering of alumina containing small amounts of a liquid phase 显示文摘 | BATEMAN C A BENNISON S J HA1MER M P | 1989 | J Am Ceram Soc1989，72，7： | 1 |
| 19 | Sensor- less operation of an ultra-high-speed switched reluctance machine 显示文摘 | BATEMAN C J MECROW B C CLOTHIER A C | 2010 | IEEE Transaction on Tndustry Applications2010，46，6： | 1 |
| 20 | Amino acid 226 in the hemagglutinin of H4N6 influenza virus determines bind- ing affinity for alpha 2,6-1inked sialic acid and infectivity levels in primary swine and human respiratory epithelial cells显示文摘 | Bateman A C Busch M G Karasin A I | 2008 | J Virol2008，82，16： | 1 |
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