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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Compound screening platform using human induced pluripotent stem cells to identify small molecules that promote chondrogenesis显示文摘Articular cartilage,which is mainly composed of collagen Ⅱ,enables smooth skeletal movement.Degeneration of collagen Ⅱ can be caused by various events,such as injury,but degeneration especially increases over the course of normal aging.Unfortunately,the body does not fully repair itself from this type of degeneration,resulting in impaired movement.Microfracture,an articular cartilage repair surgical technique,has been commonly used in the clinic to induce the repair of tissue at damage sites.Mesenchymal stem cells(MSC)have also been used as cell therapy to repair degenerated cartilage.However,the therapeutic outcomes of all these techniques vary in different patients depending on their age,health,lesion size and the extent of damage to the cartilage.The repairing tissues either form fibrocartilage or go into a hypertrophic stage,both of which do not reproduce the equivalent functionality of endogenous hyaline cartilage.One of the reasons for this is inefficient chondrogenesis by endogenous and exogenous MSC.Drugs that promote chondrogenesis could be used to induce self-repair of damaged cartilage as a non-invasive approach alone,or combined with other techniques to greatly assist the therapeutic outcomes.The recent development of human induced pluripotent stem cell(iPSCs),which are able to self-renew and differentiate into multiple cell types,provides a potentially valuable cell resource for drug screening in a“more relevant”cell type.Here we report a screening platform using human iPSCs in a multi-well plate format to identify compounds that could promote chondrogenesis. | Sheng-Lian Yang Erica Harnish Thomas Leeuw Uwe Dietz Erika Batchelder Paul SWright Jane Peppard Paul August Cecile Volle-Challier Francoise Bono Jean-Marc Herbert Juan Carlos Izpisua Belmonte | 2012 | Protein & Cell2012，3，12： | 3 |
| 3 | Transitioning antimicrobials from intravenous to oral in pediatric acute uncomplicated osteomyelitis显示文摘Osteomyelitis is a bone infection that requires prolonged antibiotic treatment and potential surgical intervention.If left untreated,acute osteomyelitis can lead to chronic osteomyelitis and overwhelming sepsis.Early treatment is necessary to prevent complications,and the standard of care is progressing to a shorter duration of intravenous(Ⅳ) antibiotics and transitioning to oral therapy for the rest of the treatment course.We systematically reviewed the current literature on pediatric patients with acute osteomyelitis to determine when and how to transition to oral antibiotics from a short Ⅳ course.Studies have shown that switching to oral after a short course(i.e.,3-7 d) of Ⅳ therapy has similar cure rates to continuing long-term Ⅳ therapy.Prolonged Ⅳ use is also associated with increased risk of complications.Parameters that help guide clinicians on making the switch include a downward trend in fever,improvement in local tenderness,and a normalization in C-reactive protein concentration.Based on the available literature,we recommend transitioning antibiotics to oral after 3-7 d of Ⅳ therapy for pediatric patients(except neonates) with acute uncomplicated osteomyelitis if there are signs of clinical improvement,and such regimen should be continued for a total antibiotic duration of four to six weeks. | Nathan Batchelder Tsz-Yin So | 2016 | World Journal of Clinical Pediatrics2016，5，3： | 2 |
| 4 | Suppression of Plasmodium chabaudi parasitemia is independent of the action of reactive oxygen intermediates and/or nitric oxide显示文摘 | Gillman BM Batchelder J Flaherty P | 2004 | Infect Immun2004，72，11： | 1 |
| 5 | Analysis of integrated urban public transportation systems显示文摘 | Batchelder James H Kullman Brian C | 1977 | Transp Res Rec1977，639，： | 1 |
| 6 | Hemodynamic alterations in focal cerebral ischemia: temporal correlation analysis for functional imaging显示文摘 | Rogowska J Batchelder KF | 1996 | Neurol Res1996，18，2： | 1 |
| 7 | In vitro transdermal delivery of the major catechins and caffeine from extract of Camellia sinensis显示文摘 | Batchelder R J Calder R J Thomas C P | 2004 | International Journal of Pharmaceutics2004，4551，： | 1 |
| 8 | CD28 costimulation is required for the expression of T-cell-dependent cellmediated immunity against blood-stage Plasmodium chabaudi malaria parasites显示文摘 | RUMMEL T BATCHELDER J FLAHERTY P | 2004 | Infect Immun2004，72，10： | 1 |
| 9 | Treatment of tachyarrhythmias by pacing 显示文摘 | Batchelder JE Zipes DP | 1975 | Arch Intern Med1975，135，8： | 1 |
| 10 | Theoretical and empirical review of multi- nmnial process tree modeling 显示文摘 | Batchelder WH Riefer DM | 1999 | Psycho Bull Rev1999，6，1： | 1 |
| 11 | Character- ization of growth, glomerular number, and tubular proteins in the developing rhesus monkey kidney显示文摘 | BATCHELDER CA KEYSER JL LEE CC | 2013 | Anat Rec (Hoboken)2013，296，11： | 1 |
| 12 | Raman microscopy using a scanning near-field optical probe显示文摘 | Webster S Smith D A Batchelder D N | 1998 | Vibra Spec1998，18，： | 1 |
| 13 | Forward-in-time-/backward-in-time trajectory (F1TT/BITT) modeling of particles and or- ganisms in the coastal ocean 显示文摘 | Batchelder H P | 2006 | Journal of Atmospheric and Oceanic Technology2006，3，5： | 1 |
| 14 | Ecosystem modeling with NEMURO within the PICES Climate Change and Carrying Capacity program显示文摘 | Harold P. Batchelder Makoto Kashiwai | 2006 | Ecological Modelling2006，，1： | 1 |
| 15 | Chlortetraeycline and oxytetracycline effects on plant growth and development in soil systems显示文摘 | BATCHELDER A R | 1982 | Journal of Environmental Quality1982，11，6： | 1 |
| 16 | Measurements of X-ray lattice constant, thermal expansivity, and isothermal compressibility of argon crystals显示文摘 | Peterson O G Batchelder D N Simmons R O | 1966 | Physical Review1966，150，2： | 1 |
| 17 | Raman micros copy using a scanning near-field optical probe显示文摘 | S Webster D A Smith D N Batchelder | 1998 | Vibrational Spectroscopy1998，18，： | 1 |
| 18 | Sydtematic Biases in Social Perception显示文摘 | KUMBASAR E A ROMNEY K BATCHELDER W H | 1994 | American Journal of Sociology1994，100，47： | 1 |
| 19 | Ontogeny of the kidney and renal developmental markers in the rhesus monkey (Macaca mulatta) 显示文摘 | Batchelder CA Lee CCI Martinez ML | 2010 | Anat Rec2010，293，11： | 1 |
| 20 | Submicron spatial resolution Raman spectroscopy and its application to stress mapping in silicon显示文摘 | Webster S Smith D A Batchelder D N Karlin S | 1999 | Synthetic Metals1999，102，： | 1 |
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