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	题名	作者	年代	出处	被引量
1	Failure of P-selectin blockade alone to protect the liver from ischemia-reperfusion injury in the isolated blood-perfused rat liver显示文摘AIM:To determine if blockade of P-selectin in the isolated blood-perfused cold ex vivo rat liver model protects the liver from ischemia-reperfusion injury. METHODS:The effect of P-selectin blockade was assessed by employing an isolated blood-perfused cold ex vivo rat liver with or without P-selectin antibody treatment before and after 6 h of cold storage in University of Wisconsin solution. RESULTS:In our isolated blood-perfused rat liver model,pre-treatment with P-selectin antibody failed to protect the liver from ischemia-reperfusion injury,as judged by the elevated aspartate aminotransferase activity. In addition,P-selectin antibody treatment did not significantly reduced hepatic polymorphonuclear leukocyte accumulation after 120 min of perfusion. Histological evaluation of liver sections obtained at 120 min of perfusion showed significant oncotic necrosis in liver sections of both ischemic control and P-selectin antibody-treated groups. However,total bile production after 120 min of perfusion was signifi cantly greater in P-selectin antibody-treated livers,compared to control livers. No signifi cant difference in P-selectin and ICAM-1 mRNAs and proteins,GSH,GSSG,and nuclear NF-κB was found between control and P-selectin antibody-treated livers. CONCLUSION:In conclusion,we have shown that blockade of P-selectin alone failed to reduced polymorphonuclear leukocyte accumulation in the liver and protect hepatocytes from ischemia-reperfusion injury in the isolated blood-perfused cold-ex vivo rat liver model.	Samuel Wyllie Neal R Barshes Saul J Karpen John A Goss	2008	World Journal of Gastroenterology2008，14，44：	4
2	Im- proved instrument for the measurement of linear pyrol- ysis rates of solids 显示文摘	Barsh M K Andersen W H Bills K W	1958	Rev Sci Instr1958，29，：	1
3	Short- and midterm results of iliac artery stenting for flush occlusion with the assistance of an occlusive contralateral iliac artery balloon显示文摘	Bechara CF Barshes NR Pisimisis G	2014	Ann Vasc Surg2014，28，1：	1
4	Behavioural and cardiovascular effects of disrupting the angiotensin Ⅱ type-2 receptor in mice 显示文摘	Hein L Barsh GS Pratt RE	1995	Nature1995，377，6551：	1
5	The genetics of pigmentation:from fancy genes to complex traits显示文摘	BARSH G S	1996	Trends Genet1996，12，8：	1
6	The role of agouti-related protein in regulating body weight显示文摘	Wilson B D Ollmann M M Barsh G S	1999	Mol Med Today1999，5，6：	1
7	Ki- netics of the surface degradation of polymethylmethac- rylate显示文摘	Chaiken R F Andersen W H Barsh M K	1960	J Chem Phys1960，32，：	1
8	Outcomes analysis for 280 patients with eholangiocarcinoma treated with liver transplantation over an 18-year period 显示文摘	Becker NS Rodriguez JA Barshes NR	2008	J Gastrointest Surg2008，12，1：	1
9	Concomitant colorectal cancer and abdominal aortic aneurysm:evolution of treatment paradigm in the endovascular era显示文摘	Lin PH Barshes NR Albo D	2008	J Am Coil Surg2008，206，5：	1
10	Behavioural and cardiovascular effects of disrupting the angiotensin Ⅱ type-2 receptor in mice显示文摘	Hein L Barsh G S Pratt R E	1995	Nature1995，377，6551：	1
11	Geneties of body-weight regulation 显示文摘	] Barsh GS Farooql IS Rahilly SO	2000	Nature2000，404，6778：	1
12	The genetics of pigmentation: From xxx gene to complex traits显示文摘		1996	Trends in Genetics1996，12，：	1
13	Liver ischemia and ischemia-reperfusion induces and trafficks the multispecific metal transporter AtpTb to bile duct canaliculi: possible preferential transport of iron into bile 显示文摘	Goss JA Barshes NR Karpen SJ	2008	Biol Trace Elem Res2008，122，1：	1
14	Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block显示文摘	Hein L Stevens ME Barsh GS	1997	Proc Natl Acad Sci U S A1997，94，12：	1
15	Genetics of body-weight regulation显示文摘	Barsh GS Farooqi SO Rahilly S		0，，：	1
16	Characterization of epithelial cell line from bovine mammary gland显示文摘	TANIA GERMAN ITAMAR BARSH	2002	In Vitro Cell2002，38，5：	1
17	Genetics of body-weight regulation 显示文摘	Barsh GS Farooqi IS O'Rahilly S	2000	Nature2000，404，：	1
18	Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family显示文摘	McIntire JJ Umetsu SE Akbari O Potter M Kuchroo VK Barsh GS Freeman GJ Umetsu DT DeKruyff RH	2001	Nat Immunol2001，2，12：	1
19	between alpha-melanocytehormone and corticotropin releasinghormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses 显示文摘	Barsh G S Akil H	2003	J Neurosci2003，23，21：	1
20	Association of an Agouti allele with fawn or sable coat color in domestic dogs显示文摘	Tom G. Berryere Julie A. Kerns Gregory S. Barsh Sheila M. Schmutz	2005	Mammalian Genome2005，，4：	1

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