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| 1 | Molecular mechanisms of liver ischemia reperfusion injury:Insights from transgenic knockout models显示文摘Ischemia reperfusion injury is a major obstacle in liver resection and liver transplantation surgery.Understanding the mechanisms of liver ischemia reperfusion injury(IRI) and developing strategies to counteract this injury will therefore reduce acute complications in hepatic resection and transplantation,as well as expanding the potential pool of usable donor grafts.The initial liver injury is initiated by reactive oxygen species which cause direct cellular injury and also activate a cascade of molecular mediators leading to microvascular changes,increased apoptosis and acute inflammatory changes with increased hepatocyte necrosis.Some adaptive pathways are activated during reperfusion that reduce the reperfusion injury.IRI involves a complex interplay between neutrophils,natural killer T-cells cells,CD4+ T cell subtypes,cytokines,nitric oxide synthases,haem oxygenase-1,survival kinases such as the signal transducer and activator of transcription,Phosphatidylinositol 3-kinases/Akt and nuclear factor κβ pathways.Transgenic animals,particularly genetic knockout models,have become a powerful tool at elucidating mechanisms of liver ischaemia reperfusion injury and are complementary to pharmacological studies.Targeted disruption of the protein at the genetic level is more specific and maintained than pharmacological inhibitors or stimulants of the same protein.This article reviews the evidence from knockout models of liver IRI about the cellular and molecular mechanisms underlying liver IRI. | Gourab Datta Barry J Fuller Brian R Davidson | 2013 | World Journal of Gastroenterology2013，19，11： | 50 |
| 2 | 肥厚型心肌病猝死危险因素分层显示文摘肥厚型心肌病(HCM)是最常见的遗传性心脏病。普通人群患病率1/500,以自然病史差异极大为特征。很多患者终生无症状,寿命与常人并无不同。有些患者有心力衰竭(心衰)或心房颤动(房颤)的症状,某些患者猝死。猝死者常常先前没有症状,年龄较轻。HCM是青年人和运动员最常见的猝死原因。因此对猝死危险进行分层,预防猝死是一个重要的临床问题。 | Paolo Spirito Barry J Maron | 2009 | 中华心血管病杂志2009，37，4： | 12 |
| 3 | 胃癌预防主要策略:根除幽门螺杆菌显示文摘迄今为止,胃癌仍然是全球最常见的三大癌症之一。据报道,中国每年就有大约400 000例的新发胃癌病例报告[1]。在一些地区,虽然胃癌的发病率和死亡率已大幅下降,但胃癌的5年生存率仍低于25%。自Robin Warren教授和笔者于1984年发现幽门螺杆菌以来,1994年世界卫生组织认定其为Ⅰ类致癌物。经过多年对全世界幽门螺杆菌感染者的治疗,已经证明根除幽门螺杆菌有助于改善个体的生活质量,预防消化性溃疡病并减少胃癌[2]。 | Barry J Marshall Alfred Chin-Yen Tay | 2018 | 新发传染病电子杂志2018，3，4： | 6 |
| 4 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 5 | Pancreatic intraepithelial neoplasia arising from an ectopic pancreas in the small bowel显示文摘BACKGROUND: Ectopic pancreatic tissue is relatively uncommon, and is characterized as pancreatic tissue with no contact with the normal pancreas, and with its own ductal system and blood supply. It is usually asymptomatic, and can be incidentally diagnosed by conventional imaging studies.METHOD: A 69-year-old woman with a prior history of bilateral breast carcinoma presented with ectopic pancreatic intraepithelial neoplasia (PanI N) that was identified incidentally in the small bowel during an oncological resection of a synchronous primary pancreatic adenocarcinoma, and renal cell carcinoma.RESULTS: The patient underwent subtotal pancreatectomy with splenectomy, regional lymphadenectomy, radical left nephrectomy, and small bowel resection with primary anastomosis of ectopic Pan IN-2. She had an uneventful hospitalization and was discharged home on postoperative day 7.CONCLUSIONS: The occurrence of ectopic PanI N is extremely unusual with only few cases previously reported in the literature. The need for negative margins after surgical resection of ectopic PanI N lesions remains controversial. | Francisco Igor Macedo Deepa Taggarshe Tafadzwa Makarawo Barry Herschman Michael J Jacobs | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 4 |
| 6 | 肥厚型心肌病猝死预防:肥厚型心肌病患者除颤器置入显示文摘从50年前认识到肥厚型心肌病(HCM)起,对HCM患者猝死危险已有了充分的认识和足够的重视。HCM是青年人(包括受训运动员)猝死最常见的原因。置入性心脏除颤器(ICD)起初用于治疗缺血性心脏病,近几年用于HCM心原性猝死的预防。临床ICD置人增加很快,是改变HCM青年患者病程的主要治疗手段。 | Barry J Maron Paolo Spirito | 2009 | 中华心血管病杂志2009，37，4： | 4 |
| 7 | 新致病基因在颅缝早闭Crouzon综合征中的初步机制研究显示文摘目的研究Rbp4(Retinol binding protein 4)、Gpc3(Glypican family of growth factor binding protein 3)、C1qtnf3(Collagenous repeat-containing sequence of 26 KDa protein)等新致病基因在颅缝早闭症中的发病机制,为疾病非手术治疗奠定理论基础。方法以Crouzon综合征Fgfr2cC342Y/+小鼠为实验模型,应用MicroCT和组织学染色,研究小鼠颅缝闭合模式;以Fgfr2cC342Y/+模型,RT-qPCR研究Rbp4、Gpc3、C1qtnf3等新致病基因的表达差异,初步探讨其在颅缝闭合过程中的调控作用;以体外培养的Fgfr2cC342Y/+小鼠颅缝细胞为模型,研究基因突变动物细胞增殖与代谢改变。结果获得Fgfr2cC342Y/+小鼠后额缝、冠状缝、人字缝、矢状缝等颅缝闭合模式,随颅骨发育、颅缝闭合,OC(Osteocalcin)、ALP(Alkalinephosphatase)表达增加,目的基因Rbp4、Gpc3、C1qtnf3表达下降,Msx2(Muscle segment homeobox gene 2)表达增加,杂合子与野生型小鼠之间均存在显著统计学差异,与前期人颅缝组织Microarray研究结果一致。Gpc1(Glypican family ofgrowth factor binding protein 1)、FliI(Flightless I)在颅缝闭合中的表达较恒定,野生型与杂合子之间未见明显统计学差异。体外培养Fgfr2cC342Y/+小鼠颅缝细胞,CellTiter96 MTS和Quant-iT Picogreen dsDNA细胞增殖与代谢分析结果显示,Fgfr2功能获得性突变可促进冠状缝细胞的增殖,从而导致成骨增加,颅缝早闭。结论 Fgfr2cC342Y/+模型新致病基因表达趋势与前期人颅缝组织Microarray研究结果一致,Rbp4、Gpc3、C1qtnf3可能在颅缝早闭中具重要调控作用。 | 杨娴娴 Jodie T Hatfield Susan J Hinze 穆雄铮 Peter J Anderson Barry C Powell | 2012 | 组织工程与重建外科杂志2012，8，5： | 3 |
| 8 | Multitarget stool DNA for colorectal cancer screening:A review and commentary on the United States Preventive Services Draft Guidelines显示文摘Multitarget stool DNA(mt-sDNA) testing was approved for average risk colorectal cancer(CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program(2014).The United States Preventive Services Task Force(USPSTF) October 2015 draft recommendation for CRC screening included mt-s DNA as an 'alternative' screening test that 'may be useful in select clinical circumstances',despite its very high sensitivity for early stage CRC.The evidence supporting mt-s DNA for routine screening use is robust.The clinical efficacy of mt-s DNA as measured by sensitivity,specificity,life-years gained(LYG),and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document,especially those requiring annual testing adherence.In a population with primarily irregular screening participation,tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual adherence.This paper reviews the evidence supporting mt-s DNA for routine screening and demonstrates,using USPSTF's modeling data,that mt-s DNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing,high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening. | Barry M Berger Bernard Levin Robert J Hilsden | 2016 | World Journal of Gastrointestinal Oncology2016，8，5： | 3 |
| 9 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 10 | 肥厚型心肌病心房颤动:决定因素、临床进程与处理显示文摘心房颤动(房颤)是一个全球性健康问题,东西方患病率相同,反映人群老化,心血管病负担加重。在肥厚型心肌病(HCM)患者中,房颤是最常见的持续性心律不齐,最常见的并发症之一,对临床病程与预后影响很大。房颤成为HCM治疗的棘手问题,特别年轻患者,需要一致的循证治疗策略。尽管HCM房颤的循证依据不多,近期证据提示,新的治疗方法给某些患者带来了希望。 | Iacopo Olivotto Paolo DiDonna Aurelio Sgalambro Massimo Baldi Barry J Maron Franco Cecchi | 2009 | 中华心血管病杂志2009，37，4： | 3 |
| 11 | Metabolism and functions of gamma-aminobutyric acid显示文摘 | Barry J Shelp Alan W Bown Michael D McLean | 1999 | Trends in Plant Science1999，，11： | 2 |
| 12 | Preparation and evaluation of potassium ferrate as an oxidant and coagulant for potable water treatment 显示文摘 | JIANG J Q BARRY L LUMINITA Q | 2001 | Environ Eng Sci2001，18，5： | 2 |
| 13 | WONCA研究论文摘要汇编——阿片类药物成瘾和使用过量:医生在社区应用纳洛酮的经验、态度和喜好显示文摘背景爱尔兰每年因阿片类药物使用过量导致的死亡超过200例。纳洛酮及阿片类药物过量用药的预防和管理应成为医疗管理优先考虑的内容。纳洛酮可有效治疗阿片类药物过量使用,目前正在考虑是否可以在无医嘱情况下更广泛地使用纳洛酮。目的明确和丰富全科医生对阿片类药物成瘾、过量服用和纳洛酮供应的观点和经验。设计与场所对隶属于爱尔兰都柏林大学全科医学系的全科医生进行匿名问卷调查。方法共有714例全科医生受邀完成匿名问卷调查,将其结果与同期全科医生实习生的调查结果进行比较。结果 714例受试者中,共有448例(62.7%)做出回应。1/3的全科医生在城市、农村和城乡混合区。75%以上做出回应的全科医生的患者有不正当使用阿片类药物经历,25%的全科医生开出美沙酮处方。1/3的全科医生赞成在社区增加纳洛酮的使用量;1/3的人愿意参加这样一个计划。与合格的全科医生相比,采用纳洛酮治疗阿片类药物过量使用、愿意参与纳洛酮给药的全科医生实习生的比例更高。纳洛酮鼻内用药优于单次(P<0.001)或多剂量的(P<0.001)肌肉注射。66.1%(n=292)的全科医生赞同更广泛地使用纳洛酮。结论全科医生认为有大量人群存在阿片类药物使用障碍,但仍对其采用阿片类药物激动剂治疗。全科医生支持纳洛酮的广泛使用,并将参与其扩展使用。因此迫切需要开展和评估支持基于全科医生分配给药的实施战略。 | 本刊编辑部 BARRY T KLIMAS J TOBIN H | 2017 | 中国全科医学2017，20，15： | 2 |
| 14 | Escherichia coli-host macrophage interactions in the pathogenesis of inflammatory bowel disease显示文摘Multiple studies have demonstrated alterations in the intestinal microbial community(termed the microbiome) in Crohn's disease(CD) and several lines of evidence suggest these changes may have a significant role in disease pathogenesis. In active and quiescent disease, both the faecal and mucosa-associated microbiome are discordant with matched controls with reduced biodiversity, changes in dominant organisms and increased temporal variation described. Mucosaassociated adherent, invasive Escherichia coli(E. coli)(AIEC), pro-inflammatory and resistant to killing by mucosal macrophages, appear to be particularly important. AIEC possess several virulence factors which may confer pathogenic potential in CD. Type-1 pili(FimH) allow adherence to intestinal cells via cell-surface carcinoembryonic antigen-related cell adhesion molecules and possession of long polar fimbrae promotes translocation across the intestinal mucosa via microfold(M)-cells of the follicle-associated epithelium. Resistance to stress genes(htrA, dsbA and hfq) and tolerance of an acidic pH may contribute to survival within the phagolysosomal environment. Here we review the current understanding of the role of mucosa-associated E. coli in Crohn's pathogenesis, the role of the innate immune system, factors which may contribute to prolonged bacterial survival and therapeutic strategies to target intracellular E. coli. | Ahmed Tawfik Paul K Flanagan Barry J Campbell | 2014 | World Journal of Gastroenterology2014，20，27： | 2 |
| 15 | The metabolism and functions of y-aminobutyric acid显示文摘 | ALAN W BOWN BARRY J SHEP | 1997 | Plant Physiology1997，115，1： | 1 |
| 16 | Objective measurement of small angles of strabismus in infants and children with photographic reflection pattern evaluation显示文摘 | Barry J C Effert R Kaupp A | 1992 | Ophthalmology1992，99，3： | 1 |
| 17 | The Chase Family of Detection Algorithms for Multiple-input Multiple-output Channels 显示文摘 | WATERS D W BARRY J R | 2004 | IEEE GLOBECOM2004，，4： | 1 |
| 18 | A 5-microm fil- ter does not reduce propofol induced pain显示文摘 | HELLIER C NEWELL S BARRY J | 2003 | Anaesthesia2003，58，8： | 1 |
| 19 | Linear signal synthesis using the Radon-Wigner transform显示文摘 | WOOD J C BARRY D T | 1994 | IEEE Trans on Signal Processing1994，42，9： | 1 |
| 20 | Validation of a onedimensional wave model for the stratified-to-slug flow regime transition, with consequences for wave growth and slug frequency 显示文摘 | Crowley C J Wallis G B Barry J J | 1992 | Int J Multiphase Flow1992，18，2： | 1 |
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