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| 1 | Expression of HER2 and bradykinin B_1 receptors in precursor lesions of gallbladder carcinoma显示文摘AIM:To determine the expression of HER2 and bradykinin B 1 receptors(B 1 R) in the two pathogenic models of gallbladder cancer:the metaplasia-dysplasia-carcinoma and the adenoma-carcinoma pathways.METHODS:Receptor proteins were visualized by immunohistochemistry on 5-μm sections of paraffin-embedded tissue.Expression of both receptors was studied in biopsy samples from 92 patients(6 males and 86 females;age ranging from 28 to 86 years,mean 56 years).High HER2 expression in specimens was additionally investigated by fluorescence in situ hybridiza-tion.Cell proliferation in each sample was assessed by using the Ki-67 proliferation marker.RESULTS:HER2 receptor protein was absent in adenomas and in normal gallbladder epithelium.On the contrary,there was intense staining for HER2 on the basolateral membrane of epithelial cells of intestinal metaplasia(22/24;91.7%) and carcinoma in situ(9/10;90%),the lesions that displayed a significantly high proliferation index.Protein up-regulation of HER2 in the epithelium with metaplasia or carcinoma in situ was not accompanied by HER2 gene amplification.A similar result was observed in invasive carcinomas(0/12).The B 1 R distribution pattern mirrored that of HER2 except that B 1 R was additionally observed in the adenomas.The B 1 R appeared either as cytoplasmic dots or labeling on the apical cell membrane of the cells composing the epithelia with intestinal metaplasia(24/24;100%) and carcinoma in situ(10/10;100%) and in the epithelial cells of adenomas.In contrast,both HER2(4/12;33%) and B 1 R(1/12;8.3%) showed a low expression in invasive gallbladder carcinomas.CONCLUSION:The up-regulation of HER2 and B1R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis. | Cesar Toledo Carola E Matus Ximena Barraza Pamela Arroyo Pamela Ehrenfeld Carlos D Figueroa Kanti D Bhoola Maeva del Pozo Maria T Poblete | 2012 | World Journal of Gastroenterology2012，18，11： | 6 |
| 2 | Self-similar solutions in weak Lp spaces of the Navier-Stokes equations 显示文摘 | Barraza O | 1999 | Revista Matematica Iberoamericana1999，12，： | 1 |
| 3 | A new char combustion kinetic model (2): Empirical validation 显示文摘 | ROJAS A BARRAZA J BARRANCO R | 2012 | Fuel2012，96，： | 1 |
| 4 | Intranasal delivery of neurotrophic factors BDNF,CNTF,EPO,and NT-4 to the CNS显示文摘 | Alcalá-Barraza S R Lee M S Hanson L R McDonald A A Frey W H 2nd McLoon L K | | 0，，： | 1 |
| 5 | Reemergence of adenovirus type 4 acute respiratory disease in military trainees: report of an outbreak during a lapse in vaccination 显示文摘 | Ludwig SL Gaydos JC | 1999 | J Infect Dis1999，179，6： | 1 |
| 6 | A methodology to evaluate coal ash content using Siderite MOssbauer spectral area显示文摘 | Medina G Tabares J A Barraza J M | 2006 | Fuel2006，85，56： | 1 |
| 7 | Self-similar solutions in weak U-spaces of the Navier-Stokes equations显示文摘 | BARRAZA 0 A | 1996 | Revista Matematica Ibe?roamericana1996，12，： | 1 |
| 8 | Positive emotional expectations predict volun- teer outcomes for new volunteers 显示文摘 | Barraza JA | 2011 | Motivation and E- motion2011，35，4： | 1 |
| 9 | Effectiveness of negative pressure closure in the integration of split thickness skin grafts: a randomized, double-masked, controlled trial 显示文摘 | Llanos S Danilla S Barraza C | 2006 | Ann Surg2006，244，5： | 1 |
| 10 | Solid neuroendocrine breast carcinomas: Incidence, clinico - pathological features and immunohistoehemical profiling显示文摘 | LOPEZ - BONET E ALONSO - RUANO M BARRAZA G A | 2008 | Oncol Rep2008，20，6： | 1 |
| 11 | Exhaled breath ma-londialdehyde as a marker of effect of exposure to air pollution inehildren with asthma显示文摘 | Romieu I Barraza VA Escamilla NC et a1 | 2008 | J Allergy Clin Immunol2008，121，4： | 1 |
| 12 | Flotation of a refuse tailing fine coal slurry显示文摘 | Juan Barraza Juan Guerrero Jorge Pineres | 2013 | Fuel Processing Technology2013，，02： | 1 |
| 13 | Laparoscopic appendicostomy for management of fecal incontinence显示文摘 | Barraza MA Crump JM | 1997 | J Pediat Surg1997，32，： | 1 |
| 14 | Effectiveness of negative pressure closure in the integration of split thickness skin grafts: a randomized, double-masked, controlled trial 显示文摘 | Llanos S Danilla S Barraza C | 2006 | Ann Surg2006，244，5： | 1 |
| 15 | Correction of retractile concealed penis显示文摘 | Lim DJ Barraza MA Stevens PS | 1995 | J Urol1995，153，5： | 1 |
| 16 | Empathy toward strangers triggers oxytocin release and subsequent generosity显示文摘 | Barraza J A Zak P J | 2009 | Annals of the New York Academy of Science2009，1167，1： | 1 |
| 17 | Flotation of a re- fuse tailing fine coal slurry显示文摘 | Juan Barraza Juan Guerrero Jorge Pixeres | 2013 | Fuel Processing Technology2013，106，： | 1 |
| 18 | Iron sulfate and feed pelleting to detoxify free gos- sypol in cottonseed diets for dairy cattle显示文摘 | BARRAZA M L COPPOCK C E BROOKS K N | 1991 | Journal of Dairy Science1991，74，10： | 1 |
| 19 | Predicting heat conduction during solidification of a food inside a freezer due to natural convection 显示文摘 | Moraga N O Barraza H G | 2002 | Journal of Food Engineering2002，56，： | 1 |
| 20 | New procedure for measuring adherence between a geosynthetic material and a bitumi- nous mixture 显示文摘 | Barraza D Z Perez M C Fresno D C | 2010 | Geotextiles and Geomembranes2010，28，5： | 1 |
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