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| 1 | Effect of aerobic and anaerobic exercises on glycemic control in type 1 diabetic youths显示文摘AIM:To evaluate the long-term effect of aerobic and/or anaerobic exercise on glycemic control in youths with type 1 diabetes.METHODS:Literature review was performed in spring and summer 2014 using Pub Med/MEDLINE,Google Scholar,Scopus,and Science Direct with the following terms:aerobic,anaerobic,high-intensity,resistance,exercise/training,combined with glycemic/metabolic control,glycated haemoglobin A1c(Hb A1c) and type 1diabetes.Only peer-reviewed articles in English were included published in the last 15 years.It was selected from 1999 to 2014.Glycemic control was measured with Hb A1 c.Studies with an intervention lasting at least 12 wk were included if the Hb A1 c was measured before and after the intervention.RESULTS:A total of nine articles were found,and they were published between the years of 2002-2011.The sample size was 401 diabetic youths(166 males and 235 females) with an age range of 10-19 years except one study,in which the age range was 13-30 years.Study participants were from Australia,Tunisia,Lithuania,Taiwan,Turkey,Brazilia,Belgium,Egypt and France.Four studies were aerobic-based,four were combined aerobic and anaerobic programs,and one compared aerobic exercise to anaerobic one.Available studies had insufficient evidence that any type of exercise or combined training would clearly improve the glycemic control in type 1 diabetic youth.Only three(two aerobic-based and one combined) studies could provide a significant positive change in glycemic control.CONCLUSION:The regular physical exercise has several other valuable physiological and health benefits that justify the inclusion of exercise in pediatric diabetes treatment and care. | Andrea Lukács László Barkai | 2015 | World Journal of Diabetes2015，6，3： | 5 |
| 2 | Survival of encapsulated islets: More than a membrane story显示文摘At present, proven clinical treatments but no cures are available for diabetes, a global epidemic with a huge economic burden. Transplantation of islets ofLangerhans by their infusion into vascularized organs is an experimental clinical protocol, the first approach to attain cure. However, it is associated with lifelong use of immunosuppressants. To overcome the need for immunosuppression, islets are encapsulated and separated from the host immune system by a permselective membrane. The lead material for this application is alginate which was tested in many animal models and a few clinical trials. This review discusses all aspects related to the function of transplanted encapsulated islets such as the basic requirements from a permselective membrane(e.g., allowable hydrodynamic radii, implications of the thickness of the membrane and relative electrical charge). Another aspect involves adequate oxygen supply, which is essential for survival/performance of transplanted islets, especially when using large retrievable macrocapsules implanted in poorly oxygenated sites like the subcutis. Notably, islets can survive under low oxygen tension and are physiologically active at > 40 Torr. Surprisingly, when densely crowded, islets are fully functional under hyperoxic pressure of up to 500 Torr(> 300% of atmospheric oxygen tension). The review also addresses an additional category of requirements for optimal performance of transplanted islets, named auxiliary technologies. These include control of inflammation, apoptosis, angiogenesis, and the intra-capsular environment. The review highlights that curing diabetes with a functional bio-artificial pancreas requires optimizing all of these aspects, and that significant advances have already been made in many of them. | Uriel Barkai Avi Rotem Paul de Vos | 2016 | World Journal of Transplantation2016，6，1： | 4 |
| 3 | Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays 显示文摘 | Barkai N Notterman DA | 1999 | Proc Natl Acad Sci U S A1999，96，12： | 1 |
| 4 | Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays 显示文摘 | ALON U BARKAI N NOTTERMAN D A | 1999 | Proceedings of the National Academy of Sciences1999，96，12： | 1 |
| 5 | Aging correlation functions for blinking nanocrystals,and other on-off stochastic processes显示文摘 | MARGOLIN G BARKAI E | 2004 | J Chem Phys2004，121，3： | 1 |
| 6 | Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays 显示文摘 | ALON U BARKAI N NOTTERMAN D A | 1999 | Proc Nat Acad Sci USA1999，96，12： | 1 |
| 7 | The extraction and purification of microbial DNA from sediments 显示文摘 | Ogram A Sayler G S Barkay T | 1987 | J Microbiol Methods1987，7，2： | 1 |
| 8 | Long-lasting sleep patterns of adult patients with mi-nor traumatic brain injury (mTBI) and non-mTBI subjects显示文摘 | Schreiber S Barkai G Gur-Hartman T Peles E Tov N DolbergO T | 2007 | Sleep Med2007，9，： | 1 |
| 9 | Broad Patterns of Gene Expression Revealed by Clustering Analysis of Tum- or and Normal Colon Tissues Probed by Oligonucleotide Arrays显示文摘 | Alon U Barkai N Notterman D A | 1999 | Proceedings of the National Academy of Scien- ces1999，96，12： | 1 |
| 10 | Theory of single-molecule spectroscopy:Beyond the ensemble average显示文摘 | BARKAI E JUNG Y SILBEY R | 2004 | Annu Rev Phys Chem2004，55，1： | 1 |
| 11 | Randomized management of the second nonvertex twin:vaginal delivery or eesarean section显示文摘 | Rabinovici J Barkai G Reiehman B | 1987 | Am J Obstet Gynecol1987，156，1： | 1 |
| 12 | Therapeutic EUS-assisted endoscopic retrograde pancreatography after failed pancreatic duct cannulation at ERCP显示文摘 | Olga Barkay Stuart Sherman Lee McHenry Byung Moo Yoo Evan L. Fogel James L. Watkins John DeWitt Mohammad A. Al-Haddad Glen A. Lehman | 2010 | Gastrointestinal Endoscopy2010，，7： | 1 |
| 13 | Broad patterns of gene expression revealed by clustering analysis of tuner and normal colon cancer tissues probed by oligonucleotide arrays显示文摘 | Alon U Barkai N Notterman D A | 1999 | Cell Biology1999，，96： | 1 |
| 14 | Horizontal gene transfer perspectives at a crossroads of scientific disciplines显示文摘 | Smets B F Barkay T | 2005 | Nat Rev Microbiol2005，3，： | 1 |
| 15 | Effect of Endoscopic Stenting of Malignant Bile Duct Obstruction on Quality of Life显示文摘 | Barkay O Mosler P Schmitt C M | 2012 | J Clin Gastroenterol2012，23，7： | 1 |
| 16 | A novel role for extracellular signal-regulated kinase in maintaining longterm memory-relevant excitability changes显示文摘 | Cohen-Matsliah SI Brosh I Rosenblum K Barkai E | 2007 | J Neurosci2007，27，12： | 1 |
| 17 | Anomalous diffusion and relaxation close to thermal equilibrium: a fractional fokker-planck equation approach显示文摘 | METZLER R BARKAI E KLAFTERL J | 1999 | Phys Rev Lett1999，82，： | 1 |
| 18 | Broad pat- terns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonueleotide ar- rays显示文摘 | ALON U BARKAI N NOTTERMAN D A | 1999 | PNAS1999，96，12： | 1 |
| 19 | Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays 显示文摘 | ALON U BARKAI N NOTTERMAN DA | 1999 | Proc Natl Acad Sci USA1999，96，12： | 1 |
| 20 | Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays显示文摘 | Alon V Barkai N Notterman DA | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
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