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| 1 | 口腔护理对危重症患者口腔健康状况和呼吸机相关性肺炎预防的影响显示文摘目的:本研究的目的是明确口腔护理措施对重症监护室患者口腔健康状况和呼吸机相关性肺炎发生率的影响。方法:本临床实验纳入2015-2016年间的100名患者,随机分为对照组(接受护士的口腔护理)和干预组(接受研究人员的系统口腔护理)。根据干预组患者的口腔健康状况,按照Beck口腔护理频次评价表(BOAS)确定需要接受口腔护理的频次。每次护理均包括调整气管内套管压力、用牙膏刷牙、使用抗菌药和嘴唇保湿。口腔检查采用BOAS和口腔黏膜菌斑量表评分,肺炎监测采用临床肺部感染评分。结果:第1~5天,两组患者的BOAS评分有统计学差异(P<0.001);第3~5天,两组患者的口腔黏膜菌斑评分有统计学差异(P<0.001);第3天和第5天,对照组肺炎发生率分别为10%(5例)和14%(7例),干预组肺炎发生率分别为4%(2例)和10%(5例),Fisher检验无统计学差异(P=0.538),但与对照组相比,干预组肺炎的发生率降低。结论:与传统的口腔护理措施比较,系统口腔护理虽然没有显著降低危重症患者呼吸机相关性肺炎的发生率,但显著改善了其口腔健康状况和口腔黏膜菌斑评分。 | Abdullah Haghighi Vida Shafipour Masoumeh Bagheri-Nesami Afshin Gholipour Baradari Jamshid Yazdani Charati | 2017 | 中国护理管理2017，17，3： | 14 |
| 2 | Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer显示文摘AIM: To investigate the antineoplastic potency of the novel insulin-like growth factor 1 receptor (IGF-1R) tyro- sine kinase inhibitor (TKI) NVP-AEW541 in cell lines and primary cell cultures of human colorectal cancer (CRC). METHODS: Cells of primary colorectal carcinomas were from 8 patients. Immunostaining and crystal violet stain- ing were used for analysis of growth factor receptor pro- tein expression and detection of cell number changes, respectively. Cytotoxicity was determined by measuring the release of the cytoplasmic enzyme lactate dehydro- genase (LDH). The proportion of apoptotic cells was determined by quantifying the percentage of sub-G1 (hypodiploid) cells. Cell cycle status reflected by the DNA content of the nuclei was detected by flow cytometry. RESULTS: NVP-AEW541 dose-dependently inhibited the proliferation of colorectal carcinoma cell lines and primary cell cultures by inducing apoptosis and cell cycle arrest. Apoptosis was characterized by caspase-3 activa- tion and nuclear degradation. Cell cycle was arrested at the G1/S checkpoint. The NVP-AEW541-mediated cell cycle-related signaling involved the inactivation of Akt and extracellular signal-regulated kinase (ERK) 1/2, the upregulation of the cyclin-dependent kinase inhibitors p21Waf1/CIP1 and p27Kip1, and the downregulation of the cell cycle promoter cyclin D1. Moreover, BAX was upregu- lated during NVP-AEW541-induced apoptosis, whereas Bcl-2 was downregulated. Measurement of LDH release showed that the antineoplastic effect of NVP-AEW541 was not due to general cytotoxicity of the compound. However, augmented antineoplastic effects were ob-served in combination treatments of NVP-AEW541 with either 5-FU, or the EGFR-antibody cetuximab, or the HMG-CoA-reductase inhibitor fluvastatin. CONCLUSION: IGF-1R-TK inhibition is a promising novel approach for either mono- or combination treatment strategies of colorectal carcinoma and even for CRC che- moprevention. | Michael Hpfner Andreas P Sutter Alexander Huether Viola Baradari Hans Scherübl | 2006 | World Journal of Gastroenterology2006，12，35： | 10 |
| 3 | Histone deacetylase inhibitor MS-275 alone or combined with bortezomib or sorafenib exhibits strong antiproliferative action in human cholangiocarcinoma cells显示文摘AIM: To investigate the antiproliferative effect of the histone deacetylase (HDAC) inhibitor MS-275 on cholangiocarcinoma cells alone and in combination with conventional cytostatic drugs (gemcitabine or doxorubicin) or the novel anticancer agents sorafenib or bortezomib. METHODS: Two human bile duct adenocarcinoma cell lines (EGI-1 and TFK-1) were studied. Crystal violet staining was used for detection of cell number changes. Cytotoxicity was determined by measuring the release of the cytoplasmic enzyme lactate dehydrogenase (LDH). Apoptosis was determined by measuring the enzyme activity of caspase-3. Cell cycle status reflected by the DNA content was detected by flow cytometry.RESULTS: MS-275 treatment potently inhibited the proliferation of EGI-1 and TFK-1 cholangiocarcinoma cells by inducing apoptosis and cell cycle arrest. MS-275-induced apoptosis was characterized by activation of caspase-3, up-regulation of Bax and down-regulation of Bcl-2. Cell cycle was predominantly arrested at the G1/S checkpoint, which was associated with induction of the cyclin-dependent kinase inhibitor p21Waf/CIP1. Furthermore, additive anti-neoplastic effects were observed when MS-275 treatment was combined with gemcitabine or doxorubicin, while combination with the multi-kinase inhibitor sorafenib or the proteasome inhibitor bortezomib resulted in overadditive anti-neoplastic effects.CONCLUSION: The growth of human cholangiocarcinoma cells can be potently inhibited by MS-275 alone or in combination with conventional cytostatic drugs or new, targeted anticancer agents. | Viola Baradari Michael Hpfner Alexander Huether Detlef Schuppan Hans Scherübl | 2007 | World Journal of Gastroenterology2007，13，33： | 10 |
| 4 | Signaling pathways involved in the inhibition of epidermal growth factor receptor by erlotinib in hepatocellular cancer显示文摘瞄准:在肝细胞癌(HCC ) 检验导致 erlotinib 的生长抑制的内在的机制。方法:在基因表示的导致 Erlotinib 的改变用 cDNA 数组技术被评估;在蛋白质表示或蛋白质激活的变化用西方的弄污由于象 IGF-1-induced EGFR transactivation 一样的 erlotinib 治疗被调查。结果:Erlotinib 治疗禁止了 mitogen 激活和抄写(STAT ) 的激活的蛋白质(地图)-kinase 小径和信号变换器调停了表明哪个导致了调整由 cDNA 数组技术示威了的基因的 apoptosis 和房间周期的一个改变的表达式。象与象 Bcl-2, Bcl-X (L) 或 jun D 一样的 antiapoptotic 因素的一条下面规定联系的 caspases 和 gadds 一样的 proapoptotic 因素的 Overexpression 说明了让 erlotinib 的力量导致 apoptosis。支持 G1/S-transition 的房间周期管理者并且在 cyclin 依赖的激酶禁止者和 gadds 的表示上的 Downregulation 响应 erlotinib 贡献了 G1/G0-arrest 的正式就职。而且,我们显示了由 IGF-1-receptor 的调停 EGFR 的发信号的 transactivation 并且在受体受体十字谈话显示出 erlotinib 的禁止的效果。结论:我们的学习在 HCC 房间和 thus 使 EGFR-TK-inhibition 的行动的机制的理解清楚些可能便于 additively 或 synergistically 行动的联合治疗的设计。而且,我们对 erlotinib 处理作出回应的小径上的数据能在以后预言肿瘤的应答的海角到 EGFR-TKIs 是有用的。 | Alexander Huether Michael Hpfner Andreas P Sutter Viola Baradari Detlef Schuppan Hans Scherübl | 2006 | World Journal of Gastroenterology2006，12，32： | 7 |
| 5 | Effect of etomidate versus combination of propofol-ketamine and thiopental-ketamine on hemodynamic response to laryngoscopy and intubation: a randomized double blind clinical trial 显示文摘 | Gholipour Baradari A Firouzian A Zamani Kiasari A | 2016 | Anesth Pain Med2016，6，30： | 1 |
| 6 | EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer显示文摘 | Huether A Hopfner M Baradari V | 2005 | Biochem pharmacol2005，70，11： | 1 |
| 7 | EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer显示文摘 | Huether A Hopfner M Baradari V | 2005 | Biochem Pharmacol2005，70，11： | 1 |
| 8 | EGFR blockade by eetuximab alone or as combination therapy for growth control of hepatocellular eaneer 显示文摘 | Huether A Hopfner M Baradari V | 2005 | Biochem Pharmaeol2005，70，11： | 1 |
| 9 | EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer 显示文摘 | Huether A Hopfner M Baradari V | 2005 | Biochem Pharmacol2005，70，11： | 1 |
| 10 | EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer显示文摘 | Huether A Hopiner M Baradari V | 2005 | Biochem Pharmacot2005，70，11： | 1 |
| 11 | EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer显示文摘 | Huether A Hopfner M Baradari V | 2005 | Biochem Pharmacol2005，70，11： | 1 |
| 12 | EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer 显示文摘 | Huether A Hopfner M Baradari V | 2005 | Biochem Pharmacol2005，70，11： | 1 |
| 13 | EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer显示文摘 | Huether A Hpfner M Baradari V | 2005 | Biochem Pharmacol2005，70，11： | 1 |
| 14 | The insulin like growth factor recep tor 1 is a promising target for novel treatment approaches in neuroendocrine gastrointestinal tumours显示文摘 | Hopfner M Baradari V Huether A | 2006 | Endocr Relat Cancer2006，13，1： | 1 |
| 15 | Hemodynarnic responses to etomidate versus ketamine-thiopental sodium combination for anesthetic induction in coronary artery bypass graft surgery patients with low ejection fraction: a double-blind, randomized, clinical trial 显示文摘 | Habibi MR Baradari AG Soleimani A | 2014 | Journal of clinical and diagnostic research : JCDR2014，8，10： | 1 |
| 16 | EGFR blockade by eetuximab alone or as combination therapy for growth control of hepatocellular cancer显示文摘 | Huether A HSpfner M Baradari V | 2005 | Bioehem Pharmacol2005，70，11： | 1 |
| 17 | EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer显示文摘 | Huether A Hpfner M Baradari V | 2005 | Biochem Pharmacol2005，70，11： | 1 |
| 18 | Sorafenib alone or as combination therapy for growth control of cholangiocarcinoma显示文摘 | Huether A H(o)pfner M Baradari V | 2007 | Riochem Pharmacol2007，73，9： | 1 |
| 19 | Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells显示文摘 | Michael H?pfner Alexander Huether Andreas P. Sutter Viola Baradari Detlef Schuppan Hans Scherübl | 2006 | Biochemical Pharmacology2006，，10： | 1 |
| 20 | The effect of intravenous vitamin C on the phosphorus level reduction in hemodialysis patients: A double blind randomized clinical trial显示文摘 | Gholipour Baradari A Emami Zeydi A Espahbodi F | 2012 | Med Glas (Zenica)2012，9，1： | 1 |
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