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| 1 | UVR8 Mediates UV-B-Induced Arabidopsis Defense Responses against Botrytis cinerea by Controlling Sinapate Accumulation显示文摘光对草食动物和病原体作为植物免疫者回答的一个中央管理者正在出现。太阳的 UV-B 放射作为植物防卫的一个积极调节的人起一个重要作用。然而,自从 UV-B,光子能在植物纸巾与大量分子的目标交往,调停的机制他们植物防卫上的效果留下了逃犯。这里,我们证明 UV-B 放射的生态地有意义的剂量增加 Arabidopsis 抵抗到 necrotrophic 真菌 Botrytis cinerea 并且这效果被光敏电阻器 UVR8 调停。植物抵抗上的 UV-B 效果在在发信号的 jasmonate ( JA )损害的异种被保存( jar1-1 和 P35S : JAZ10.4 )或导出色氨酸的防卫混合物的新陈代谢( pen2-1 , pad3-1 , pen2 pad3 ),建议 JA 小径的任何一条规定也不在 indolic glucosinolates ( iGS )或 camalexin 的层次变化涉及这回答。UV-B 放射,通过 UVR8 行动,在叶织物增加了 flavonoids 和 sinapates 的层次。病原体抵抗上的 UV-B 效果在 tt4-1 仍然是可检测的,在 chalcone synthase 并且因此缺乏的异种在 flavonoids 的合成损害了,但是在 fah1-7 是不在的,在 ferulic 酸 5-hydroxylase 缺乏的异种,它为 sinapate 生合成是必要的。一起,这些结果显示 UVR8 在调停起一个重要作用由控制 sinapate biosynthetic 小径的表示的病原体抵抗上的 UV-B 放射的效果。 | Patricia V. Demkura Carlos L. Ballare' | 2012 | Molecular Plant2012，5，3： | 15 |
| 2 | Early endoscopic ultrasonography in acute biliary pancreatitis: A prospective pilot study显示文摘AIM: To investigate the clinical usefulness of early endoscopic ultrasonography(EUS) in the management of acute biliary pancreatitis(ABP).METHODS: All consecutive patients entering the emergency department between January 2010 and December 2012 due to acute abdominal pain and showing biochemical and/or radiological findings consistent with possible ABP were prospectively enrolled. Patients were classified as having a low,moderate,or high probability of common bile duct(CBD) stones,according to the established risk stratification. Exclusion criteria were: gastrectomy or patient in whom the cause of biliary obstruction was already identified by ultrasonography. All enrolled patients underwent EUS within 48 h of their admission. Endoscopic retrograde cholangiopancreatography was performed immediately after EUS only in those cases with proven CBD stones or sludge. The following parameters were investigated:(1) clinical: age,sex,fever;(2) radiological: dilated CBD; and(3) biochemical: bilirubin,AST,ALT,g GT,ALP,amylase,lipasis,PCR. Association between presence of CBD stone at EUS and the individual predictors wereassessed by univariate logistic regression. Predictors significantly associated with CBD stones(P < 0.05) were entered in a multivariate logistic regression model.RESULTS: A total of 181 patients with pancreatitis were admitted to the emergency department between January 2010 and December 2012. After exclusion criteria a total of 71 patients(38 females,53.5%,mean age 58 ± 20.12 years,range 27-89 years; 33 males,46.5%,mean age 65 ± 11.86 years,range 41-91 years) were included in the present study. The probability of CBD stones was considered low in 21 cases(29%),moderate in 26(37%),and high in the remaining 24(34%). The 71 patients included in the study underwent EUS,which allowed for a complete evaluation of the target sites in all the cases. The procedure was completed in a mean time of 14.7 min(range 9-34 min),without any notable complications.The overall CBD stone frequency was 44%(31 of 71),with a significant increase from the group at low pretest probability to that at moderate(OR = 5.79,P = 0.01) and high(OR = 4.25,P = 0.03) pretest probability.CONCLUSION: Early EUS in ABP allows,if appropriate,immediate endoscopic treatment and significant spare of unnecessary operative procedures thus reducing possible related complications. | Andrea Anderloni Marianna Galeazzi Marco Ballarè Michela Pagliarulo Marco Orsello Mario Del Piano Alessandro Repic | 2015 | World Journal of Gastroenterology2015，21，36： | 14 |
| 3 | Endoscopic ultrasound-guided ethanol ablation ofpancreatic neuroendocrine tumours:A case study andliterature review显示文摘Here we offer a review of the literature regarding endoscopic ultrasound-guided ethanol ablation for pancreatic neuroendocrine tumours and describe the case of a cystic tumour completely ablated after a multisession procedure. A total of 35 PubM ed indexed cases of treated functioning and non-functioning pancreatic neuroendocrine tumours resulted from our search, 29 of which are well-documented and summarised. Endoscopic ultrasound-guided ethanol ablation appears as a local, minimally invasive treatment of pancreatic neuroendocrine tumours, suitable for selected patients. This technique appears feasible, relatively safe and efficient, especially when applied to symptom relief in functioning tumours, aiming at loss of endocrine secretion. For non-functioning tumours, where the goal is complete tissue ablation, eus guided ethanol ablation can provide good results for patients who are unfit for surgery or for those who refuse surgical resection. Its role in 'fit for surgery' patients requires assessment through further studies. | Elia Armellini Stefano F Crinò Marco Ballarè Socrate Pallio Pietro Occhipinti | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，3： | 3 |
| 4 | The E3 Ubiquitin Ligase gp78 Protects against ER Stress in Zebrafish Liver显示文摘Enhanced endoplasmic reticulum(ER)-associated protein degradation(ERAD) activity by the unfolded protein response(UPR) represents one of the mechanisms for restoring ER homeostasis.In vitro evidence indicates that the mammalian gp78 protein is an E3 ubiquitin ligase that facilitates ERAD by polyubiquitinating and targeting proteins for proteasomal degradation under both physiologic and stress conditions.However,the in vivo function of gp78 in maintaining ER protein homeostasis remains untested.Here we show that like its mammalian counterpart,the zebrafish gp78 is also an E3 ubiquitin ligase as revealed by in vitro ubiquitination assays.Expression analysis uncovered that gp78 is highly expressed in several organs,including liver and brain,of both larval and adult fish.Treatment of larvae or adult fish with tunicamycin induces ER stress and upregulates the expression of several key components of the gp78 ERAD complex in the liver.Moreover,liver-specific overexpression of the dominant-negative form of gp78(gp78-R2M) renders liver more sensitive to tunicamycin-induced ER stress and enhances the expression of sterol response element binding protein(Srebp)-target genes,which was largely suppressed in fish overexpressing wild-type gp78.Together,these data indicate that gp78 plays a critical role in protecting against ER stress in liver. | Zhiliang Chen Petek Ballar Yu Fu Jia Luo Shaojun Du Shengyun Fang | 2014 | Journal of Genetics and Genomics2014，41，7： | 3 |
| 5 | Two domains of the progesterone receptor interact with the estrogen receptor and are required for progesterone activation of the eSrc/Erk pathway in mammalian cells显示文摘 | Ballare C Uhrig M Bechtold T | 2003 | Mol Cell Biol2003，23，： | 1 |
| 6 | Keeping up with the neighbours:phytochrome sensing and other signalling mechanisms显示文摘 | BALLAR~ C L | 1999 | Trends Plant Sci1999，4，3： | 1 |
| 7 | Stress under the sun: spotlight on ul- traviolet-B responses显示文摘 | BALLAR C L | 2003 | Plant Physiology2003，132，4： | 1 |
| 8 | Dual role of lignin in plant litterdecomposition in terrestrial ecosystems显示文摘 | Austin A T Ballare C L | 2010 | Proceedingsof the National Academy of Sciences2010，107，10： | 1 |
| 9 | Light regulation of plant defense显示文摘 | Ballare CL | 2014 | Annu Rev Plant Biol2014，65，： | 1 |
| 10 | Progestin activation of nongenomic pathways via cross talk of progesterone receptor with estrogen receptor beta induces proliferation of endometrial stromal cells显示文摘 | Vallejo G Ballare C Baraflao JL | 2005 | Mol Endocrinol2005，19，2： | 1 |
| 11 | Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation显示文摘 | Ballar P Zhong Y Nagahama M | 2007 | J BioI Chern2007，282，33： | 1 |
| 12 | Progestin activa- tion of nongenomie pathways via cross talk of progester- one receptor with estrogen receptor beta induces prolifer- ation of endometrial stromal cells 显示文摘 | Vallejo G Ballare C Baranao JL | 2005 | Mol Endocrinol2005，19，12： | 1 |
| 13 | Tenrrestrial ecosysterms,increased solar ultraviolet radiation and interaction with other climatic change factors显示文摘 | Caldwell M M Bomman J F Ballare C L | 2003 | Photochemical & Photobioiogieal Sciences2003，2，： | 1 |
| 14 | Endoscopy or surgery for malignant GI outlet obstruction? 显示文摘 | Del Piano M Ballare M Montino F | 2005 | Gastrointest Endosc2005，61，： | 1 |
| 15 | Combined evaluation of total and functional liver plasma flows and intrahepatic shunting显示文摘 | Molino G Avagnia P Ballare M | 1991 | Dig Dis Sci1991，36，9： | 1 |
| 16 | Endoscopy or surgery for malignant GI outlet obstruction? 显示文摘 | Piano MD Ballare M Montino F | 2005 | Gastrointest Endosc2005，61，3： | 1 |
| 17 | Light signals perceived by crop and weed plants显示文摘 | BALLARE C L CASAL J J | 2000 | Field Crops Research2000，67，： | 1 |
| 18 | SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy显示文摘 | Wang Y Ballar P Zhong Y | 2011 | PLoS One2011，6，24： | 1 |
| 19 | Dual role of lignin in plant litter decomposition in terrestrial ecosystems显示文摘 | Austin A T Ballare C L | 2010 | Proceedings of the National Academy of Sciences of the United States of America2010，107，10： | 1 |
| 20 | Treatment with interferon-α2b of naive non-cirrhotic patients with chronic hepatitis C according to viraemia and genotype. Results of a randomized multicentre study显示文摘 | Giorgio Saracco Alessia Ciancio Valeria Ghisetti Giuseppe Rocca Giuseppe Cariti Massimo Andreoni Marco Tabone Luigi Roffi Guido Calleri Marco Ballaré Natalia Terreni Massimo Sartori Gian Franco Tappero Antonio Traverso Antonio Poggio Annamaria Orani Giova | 2001 | European Journal of Gastroenterology & Hepatology2001，，2： | 1 |
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