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| 1 | A novel protein-repellent dental composite containing 2-methacryloyloxyethyl phosphorylcholine显示文摘Secondary caries due to biofilm acids is a primary cause of dental composite restoration failure.To date,there have been no reports of dental composites that can repel protein adsorption and inhibit bacteria attachment.The objectives of this study were to develop a protein-repellent dental composite by incorporating 2-methacryloyloxyethyl phosphorylcholine(MPC) and to investigate for the first time the effects of MPC mass fraction on protein adsorption,bacteria attachment,biofilm growth,and mechanical properties.Composites were synthesized with 0(control),0.75%,1.5%,2.25%,3%,4.5%and 6%of MPC by mass.A commercial composite was also tested as a control.Mechanical properties were measured in three-point flexure.Protein adsorption onto the composite was determined by the microbicinchoninic acid method.A human saliva microcosm biofilm model was used.Early attachment at 4 h,biofilm at 2 days,live/dead staining and colony-forming units(CFUs) of biofilms grown on the composites were investigated.Composites with MPC of up to 3%had mechanical properties similar to those without MPC and those of the commercial control,whereas 4.5%and 6%MPC decreased the mechanical properties(P<0.05).Increasing MPC from 0 to 3%reduced the protein adsorption on composites(P<0.05).The composite with 3%MPC had protein adsorption that was 1/12 that of the control(P<0.05).Oral bacteria early attachment and biofilm growth were also greatly reduced on the composite with 3%MPC,compared to the control(P<0.05).In conclusion,incorporation of MPC into composites at 3%greatly reduced protein adsorption,bacteria attachment and biofilm CFUs,without compromising mechanical properties.Protein-repellent composites could help to repel bacteria attachment and plaque build-up to reduce secondary caries.The protein-repellent method might be applicable to other dental materials. | Ning Zhang Chen Chen Mary AS Melo Yu-Xing Bai Lei Cheng Hockin HK Xu | 2015 | International Journal of Oral Science2015，7，2： | 8 |
| 2 | Influence of IFNα-2b and BCG on the release of TNF and IL-1 by Kupffer cells in rats with hepatoma显示文摘INTRODUCTIONKupffer cells are residential macrophages in the liver ,which play a critical role in the maintenance of normal liver function and in immunal surveilance of hepatocellular carcinoma (HCC) and other cancers[1].The biological immune modulants have cancers[2].In our previous studies ,the combined use of biological immune modulants showed better dffects . | Xian Yong Bai~1 Xiu Hong Jia~2 Ling Zhong Cheng~3 Yun Di Gu~3 ~1Department of Histology and Embryology,Binzhou Medical College,Binzhou 256603,Shandong Province,China ~2Departrnent of Pediatrics,Binzhou Medical College,Binzhou 256603,Shandong Province,China ~3Department of Histology and Embryology,Shanghai Medical University,Shanghai 200032,ChinaDr.Xian Yong Bai graduated from the Shanghai Medical University as a postgraduate in 1995,Professor of Histology and Embryology,specialized in hepatic tumor immunology,having 36 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 7 |
| 3 | Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice显示文摘 | Bai C Fukuda N Song Y Ma T Matthay MA Verkman AS | 1999 | J Clin Invest1999，103，4： | 1 |
| 4 | A clinical and videostroboscopic evaluation of laryngeal tuberculosis 显示文摘 | Agarwal P Bais AS | 1998 | J Laryngol Otol1998，112，6： | 1 |
| 5 | Rapid detection of avian intluenza virus A and subtype H5N1 by single step multiplex reverse transcription -polYmerase chain reaction 显示文摘 | Wei HL Bai GR Mweene AS | 2006 | Virus Genes2006，32，3： | 1 |
| 6 | A clinical and videostroboscopic eval- uation of laryngeal tuberculosis 显示文摘 | Agarwal P Bais AS | 1998 | J Laryngol Otol1998，112，1： | 1 |
| 7 | Rapid detection of avian influenza virus A and subtype H5N1 by single step multiplex reverse transcription-polymerase chain reaction 显示文摘 | Wei HL Bai GR Mweene AS | 2006 | Virus Genes2006，32，3： | 1 |
| 8 | Alliance of epigenetic forces for the activation of oncogenic Writ/β -catenin signaling 显示文摘 | Bai AH Cheng AS | 2013 | J Gastroenterol Hepatol2013，28，3： | 1 |
| 9 | Rapid detection of avian influenza virus a and subtype HSN1 by single step multiplex reverse transcription-polymerase chain reaction显示文摘 | Wei HL Bai GR Mweene AS | 2006 | Virus Genes2006，32，3： | 1 |
| 10 | Total elbow arthroplasty: a radiographic outcome study显示文摘 | Bai XS Petscavage-Thomas JM Ha AS | 2016 | Skeletal Radiol2016，45，6： | 1 |
| 11 | FHIT gene expression in human urinary bladder transitional cell carcinomas显示文摘 | Skopelitou AS Gloustianou G Bai M | 2001 | In Vivo2001，15，2： | 1 |
| 12 | In silico identification of a coreregulatory network of OCT-4 in human embryonic stem cells usingan integrated approach 显示文摘 | Chavez L Bais AS Vingron M | 2009 | BMC Genomics2009，10，： | 1 |
| 13 | FHIT gene expression in human urinary bladder transitional cell carcinomas显示文摘 | Skopelitou AS Gloustianou G Bai M | 2001 | In Vivo2001，15，2： | 1 |
| 14 | FHIT gene expression in human urinary bladder transitional cell carcinomas显示文摘 | Skopelitou AS Gloustianou G Bai M | 2001 | In Vivo2001，15，2： | 1 |
| 15 | Rapid detection of avian influenza virus a and subtype H5N1 by single step multiplex reverse transcription-polymerase chain reaction显示文摘 | Wei HL Bai GR Mweene AS | 2006 | Virus Genes2006，32，3： | 1 |
| 16 | A clinical and videostrobosopic evaluation of laryngeal tuberculosis显示文摘 | Agarwal P Bais AS | 1998 | J Laryngol Otol1998，112，1： | 1 |
| 17 | A STREAM-LINED PROCEDURE FOR DETERMINATION OF STARCH,NON-STARCH POLYSACCHARIDES AND FREE SUGARS IN CEREALS显示文摘A STREAM-LINED PROCEDURE FOR DETERMINATION OF STARCH,NON-STARCH POLYSACCHARIDES AND FREE SUGARS IN CEREALSASTREAM-LINEDPROCED... | Tian, FL Bai, T Gao, AS Saren, C Choct, M | 1995 | Chinese Chemical Letters1995，6，9： | 0 |
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