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| 1 | Altered spontaneous contractions of the ileum by anesthetic agents in rats exposed to peritonitis显示文摘AIM:To investigate in vitro effects of propofol,midazolam and dexmedetomidine,which are commonly used anaesthesic or sedatives,on spontaneous contractions of the ileum both in normal rats and those exposed to hyperdynamic peritonitis.METHODS:Spontaneous contractions of isolated ileum muscle segments from sham operated rats and those exposed to peritonitis,were studied in vitro.The amplitude and the frequency of spontaneous contractions of ileum muscle segments were studied after adding dexmetetomidine,propofol,and midazolam to the organ bath in a cumulative manner.RESULTS:Both amplitude(85.2±6.6 vs 47.4±7.1)and frequency(32.8±4.6 vs 20.2±3.9)of spontaneous contractions in ileum smooth muscle segments were decreased significantly in the peritonitis group compared to the control group(P<0.05).Dexmedetomidine significantly increased the amplitude of spontaneous contractions(85.2±6.6 vs 152.0±5.4,P<0.05)whereas,propofol(85.2±6.6 vs 49.6±4.8,P<0.05)and midazolam(85.2±6.6 vs 39.2±4.5,P<0.05)decreased it in both control and peritonitis groups.The frequency of spontaneous contractions were significantly decreased by propofol in both control(32.8±4.6 vs 18.2±3.4,P<0.05)and peritonitis groups 20.2±3.9 vs 11.6±3.2,P<0.05).Dexmedetomidine and midazolam did not cause significant changes in the number of spontaneous contractions in both control and the peritonitis groups(P>0.05).CONCLUSION:Propofol,midazolam and dexmedetomidine have various in vitro effects on spontaneous contractions of the rat ileum.While dexmedetomidine augments the spontaneous contraction of the rat ileum,propofol attenuates it.However,the effects of these compounds were parallel in both control and peritonitis groups. | Cengiz Aydin Ihsan Bagcivan Sinan Gursoy Ahmet Altun Omer Topcu Ayhan Koyuncu | 2009 | World Journal of Gastroenterology2009，15，13： | 6 |
| 2 | Advancement of a nanolaminated TiHfN/CrN PVD tool coating by a nanostructured CrN top layer in interaction with a biodegradable lubricant for green metal forming显示文摘 | Bobzin K Bagcivan N Immich P | | 0，，20： | 1 |
| 3 | Numerical and experi- mental determination of plasma temperature during air plas- ma spraying with a multiple cathodes torch 显示文摘 | Bobzin K Bagcivan N Petkovic I | 2011 | Journal of Thermal Spray Technology2011，，211： | 1 |
| 4 | Effects of NO/L-Arginine Pathway on Gallbladder Contractility in Bile Duet Ligated Guinea Pigs 显示文摘 | Soylu S Aydin C Bagcivan I | 2009 | Surg Res2009，155，1： | 1 |
| 5 | Investigation of the relaxant effect of propofol on ovalbumin-induced asthma in guinea pigs显示文摘 | Bagcivan I Cevit O Yildirim MK | 2007 | Eur J Anaesthesiol2007，24，9： | 1 |
| 6 | Carbon based tool coatings as an approach for environmentally friendly metal forming processes 显示文摘 | KLOCKE F MAMANN 1' BOBZIN K LUGSCHEIDER E BAGCIVAN N | 2006 | Wear2006，260，3： | 1 |
| 7 | Mechanical Properties and Oxidation Behavioar of(A1, Cr) N and( A1, Cr, Si) N Coat- ings for Cutting Tools Deposited by HPPMS 显示文摘 | Bobzin K Bagcivan N Immich P | 2008 | Thin Solid Films2008，517，： | 1 |
| 8 | Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats显示文摘 | Gursoy S Ozdemir E Bagcivan L | 2011 | Ups JMed Sci2011，116，4： | 1 |
| 9 | Investigation of the relaxant effects of propofol on ovalbumin-induced asthma in guinea pigs显示文摘 | BAGCIVAN I CEVIT O YILDIRIM MK | 2007 | Eur J Anaesthesiol2007，24，9： | 1 |
| 10 | Thermal Cycling Behaviour of Lanthanum Zirconate as EB-PVD Thermal Barrier Coating显示文摘 | Bobzin K Lugscheider E Bagcivan N | | 0，，07： | 1 |
| 11 | Thermal cycling behavior of Yttria Stabilized Zirconia and Lanthanum Zirconate as graded and bilayer EB-PVD thermal barrier coatings显示文摘 | Bobzin K Lugscheider E Bagcivan N | 2006 | 2006，，01： | 1 |
| 12 | Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats显示文摘 | Gursoy S Ozdemir E Bagcivan I | 2011 | Ups J Med Sci2011，116，： | 1 |
| 13 | Advantages of Nano-composite Coatings Deposited by High Power Pulse Magnetron Sputtering Technology显示文摘 | BOBZIN K BAGCIVAN N IMMICH P | 2008 | J Mater Process Tech- nol2008，209，： | 1 |
| 14 | Evaluation of urinary bladder function after acute spinal cord injury:an experimental study显示文摘 | Oztemur Z Tezeren G Bagcivan I | | 0，，2： | 1 |
| 15 | Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats显示文摘 | Gursoy S Ozdemir E Bagcivan I | 2011 | Upsala J Med Sci2011，116，6： | 1 |
| 16 | Advantages of nanocomposite coatings deposited by high power pulse magnetron sputtering technology 显示文摘 | Bobzin K Bagcivan N Immich P | 2009 | Journal of Materials Processing Technology2009，209，1： | 1 |
| 17 | DC-MSIP/HPPMS (Cr, A1,V)N and (Cr, AI,W)N thin films for high-temperature friction reduction显示文摘 | BOBZIN K BAGCIVAN N EWERING M | 2011 | Surface & Coatings Technology2011，205，： | 1 |
| 18 | Advantages of nanocomposite coatings deposited by high power pulse magnetron sputtering technology显示文摘 | K. Bobzin N. Bagcivan P. Immich S. Bolz J. Alami R. Cremer | 2008 | Journal of Materials Processing Tech2008，，1： | 1 |
| 19 | Ther-mal stability ofγ-Al2O3coatings for challenging cutting ope-rations显示文摘 | BOBZIN K BAGCIVAN N REINHOLDT A | 2010 | Surface and Coatings Technology2010，205，5： | 1 |
| 20 | Advantages of Nanocomposite Coatings Deposited by High Power Pulse Magnetron Sputtering Technology显示文摘 | BOBZIN K BAGCIVAN N IMMICH P | 2009 | Journal of Materials Processing Technology2009，209，1： | 1 |
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