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| 1 | 抗生素耐药性环境中产生和转移的人类健康风险评估(HHRA)显示文摘[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性病原体所致的抗生素治疗失败中所起的作用。[方法]作者参加了2012年3月4—8日在加拿大魁北克省举行的研讨会,定义抗生素耐药性风险与人类健康环境评估的范围和目标。我们专注于环境中耐药性产生'热点区域'的关键要素,(与食品无关的)暴露评估以及剂量反应,以描述风险特征,从而改善抗生素耐药性管理的方案。[讨论]识别传统风险评估中有助于评估环境中抗生素耐药性的各个新方面。包括:a)解释附加的选择压力对环境耐药基因组的作用,即随着时间的推移,促使抗生素耐药性细菌(ARB)产生;b)在相关的环境组成部分的'热点区域'中识别和描述水平基因转移(HGT)率;c)针对不同健康结局和途径的ARB剂量修改传统的剂量反应方法。[结论]我们建议将抗生素耐药性产生造成的环境影响纳入所有涉及ARB的HHRA过程之中。由于可用的数据有限,一种多标准决策分析方法将有助于进行环境中抗生素耐药性的HHRA,并使风险管理者了解环境抗生素耐药性。 | Nicholas J.Ashbolt Alejandro Amézquita Thomas Backhaus Peter Borriello Kristian K.Brandt Peter Collignon Anja Coors Rita Finley William H.Gaze Thomas Heberer John R.Lawrence D.G.Joakim Larsson Scott A.McEwen James J.Ryan Jens Schnfeld Peter Silley Jason R.Snape Christel Van den Eede Edward Topp 王晓宇 张伊人 操仪 | 2014 | 环境与职业医学2014，31，2： | 3 |
| 2 | Prognostic utility of global longitudinal strain in myocardial infarction显示文摘Cardiovascular magnetic resonance(CMR) represents the reference standard for cardiac morphology and function assessment. Since introduction in 2009, CMR feature tracking(CMR-FT) has become a frequently used tool in the assessment of myocardial deformation and wall motion on the basis of routinely acquired b-SSFP cine images. Extensive validation has led to excellent intra-and inter-observer as well as inter-study reproducibility. CMR-FT derived myocardial deformation indices such as left ventricular(LV) strain have been shown to be impaired in cardiac diseases such as cardiomyopathies as well as myocardial infarction. Although LV ejection fraction(LVEF) is the routinely and frequently utilized parameter for systolic myocardial function assessment and major adverse clinical event(MACE) prediction, it fails to assess regional differences. Recently, LV strain has emerged as a superior measure for risk assessment and MACE prediction as compared to the established markers e.g., LVEF. This editorial aims to elucidate current discussions in the field of strain assessment in myocardial infarction in the light of recent data from a large prospective multicentre CMR study. | Andreas Schuster Soren J Backhaus Thomas Stiermaier Ingo Eitel | 2018 | World Journal of Cardiology2018，10，5： | 2 |
| 3 | The single substance and mixture toxicity of quinolines to the bioluminescent bacterium Vibrio fischeri显示文摘 | Backhaus T Scholze M Grimme L H | 2000 | Aquatic Toxicology2000，49，12： | 2 |
| 4 | Joint algal toxicity of 16 dissimilarly acting chemicals is predictable by the concept of independent action显示文摘 | Faust M Altenburger R Backhaus T | 2003 | Aquatic Toxicology2003，63，1： | 2 |
| 5 | Application and validation of approaches for the predictive hazard assessment of realistic pesticide mixtures 显示文摘 | Junghans M Backhaus T Faust M | 2006 | Aquatic Toxicology2006，76，： | 1 |
| 6 | Toxicity testing with Vibrio fischeri:A comparison between the long term(24 h)and the short term(30 min)bioassay显示文摘 | Backhaus T Froehner K Altenburger R | | 0，，12： | 1 |
| 7 | A thermoacoustic stirling heat engine显示文摘 | SWIFT W | 1999 | Nature1999，399，： | 1 |
| 8 | Clara cell protein 16: A biomarker for detecting secondary respiratory complications in patients with multiple injuries 显示文摘 | Wutzler S Backhaus L Henrich D | 2012 | J Trauma Acute Care Surg2012，73，4： | 1 |
| 9 | A thermoacoustic stirling heat engine显示文摘 | Backhaus S Swift G W | 1999 | Nature1999，399，6734： | 1 |
| 10 | High-temperature self-circulating thermoacoustic heat exchanger 显示文摘 | Backhaus S Swift G W Reid R S | 2005 | APPLIED PHYSICS LETTERS2005，，： | 1 |
| 11 | A Thermoacoustic-Stirling Heat Engine: Detailed Study 显示文摘 | Backhaus S Swift G W | 2000 | J Acoust Soc Am2000，107，6： | 1 |
| 12 | Xenobiotic biotrasformation in unicellular green algae 显示文摘 | Thies F Backhaus T Bossmann B | 1996 | Plant Physiol1996，112，： | 1 |
| 13 | A three-dimensional model for the simulation of shelf sea dynamics显示文摘 | Backhaus J O | 1985 | Deutsche Hydrographische Zeitschrift1985，38，： | 1 |
| 14 | Vibriofischeri显示文摘 | T Backhaus M Scholze LH Grimme | | 0，，1： | 1 |
| 15 | Muhilingualism in Tokyo: A look into the linguistic landscape 显示文摘 | Backhaus P | 2006 | International Journal of Multilingualism2006，3，： | 1 |
| 16 | Signs of multilingualism in Tokyo--A diachronic look at the linguistic landscape 显示文摘 | Backhaus P | 2005 | International Journal of the Sociology of Language2005，，： | 1 |
| 17 | A thermoacoustic Stirling heat engine 显示文摘 | Backhaus S Swift G W | 1999 | Nature1999，399，17： | 1 |
| 18 | Simulation of tides residual flow and energy budget in the Gulf of California 显示文摘 | CARBAJAL N BACKHAUS J O | 1998 | Oceanologica Acta1998，21，3： | 1 |
| 19 | Cytomegalovirus and proliferative signals in the vascular wall of CABG patients 显示文摘 | Westphal M Lautenschlager I Backhaus C | 2006 | Thorac Cardiovasc Surg2006，54，： | 1 |
| 20 | Travelling-wave thermoacoustic electric generator显示文摘 | Backhaus S Tward E Petach M | 2004 | Applied Physics Letters2004，85，6： | 1 |
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