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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Strain-induced po- larization rotation in epitaxial (001) BiFeOa thin films 显示文摘 | Jang H W Back S H Ortiz D | 2008 | PhysRevLett2008，101，10： | 1 |
| 3 | 显示文摘 | Backes W H Bobbers P A Vanhaeringen W | 1994 | Phys Rev B1994，49，： | 1 |
| 4 | Chirp (2~7 kHz) echo characters of the South Korea Plateau,East Sea:Styles of mass movement and sediment gravity flow显示文摘 | LEE S H CHOUGH S K BACK G G | 2002 | Marine Geology2002，184，： | 1 |
| 5 | Evolutionary Computation: Comments on the History and Current State 显示文摘 | Back T Hammel U Schwefel H P | 1997 | IEEE Transactions on Evolutionary Computation1997，1，1： | 1 |
| 6 | The immunohistochemical overexpression of ribonucleotide reductase regulatory subunit M1 ( RRMI ) protein is a predictor of shorter survival to gemcitabine-based chemotherapy in advanced non-small cell lung cancer (NSCLC)显示文摘 | Lee J J Maeng C H Back S K | 2010 | Lung Cancer2010，70，2： | 1 |
| 7 | Radiation emission at channeling of electrons in a strained layer Sil-x Gex undulator crystal 显示文摘 | Backe H Krambrich D Lauth W | 2013 | Nuclear Instruments and Methods in Physics Research2013，309，： | 1 |
| 8 | Constitutively wilted 1,a member of the rice YUCCA gene family,is required for maintaining water homeostasis and an appropriate root to shoot ratio显示文摘 | Woo Y M Park H J Su'udi M Yang J I Park J J Back K Park Y M An G | 2007 | Plant Molecular Biology2007，65，1： | 1 |
| 9 | Reactivity of alkaline lignite fly ashes towards CO2 in water 显示文摘 | Back M Kuehn M Stanjek H | 2008 | Environmental Science and Technology2008，42，12： | 1 |
| 10 | Urine alhumin/creatinine ratio for the assessment of albuminuria in pregnancy hyperten- siom显示文摘 | Nisell H Trygg M Back R | 2006 | Acta Obstet Gynecol Scand2006，85，11： | 1 |
| 11 | Analysis of heavy-ion fusion reactions at extreme sub-barrier energies显示文摘 | Jiang C L Esbensen H Back B B | 2004 | Phys Rev C2004，69，14： | 1 |
| 12 | Volatile components in flavour concentrates from crayfish processing waste显示文摘 | Cha Y J Back H H Hsieh T C Y | 2006 | Journal of the Science of Food and Agriculture2006，58，2： | 1 |
| 13 | Adding robustness to nominal output-feedback controllers for uncertain nonlinear systems:A nonlinear version of disturbance observer 显示文摘 | Back J Shim H | 2008 | Automatica2008，44，10： | 1 |
| 14 | ^1H MR Spectroscopy of the brain: absolute quantification of metabolites显示文摘 | Jacobus J F Backes W H Nicolay K | 2006 | Radiology2006，240，2： | 1 |
| 15 | Resveratrol:A review of preclinical studies for human cancer prevention显示文摘 | Athar M Back J H Tang X W | 2007 | Toxicology and Applied Pharmacology2007，224，3： | 1 |
| 16 | Natural algorithms for choosing source locations in active control systems 显示文摘 | Back K H Elliott S J | 1995 | Journal of Sound and Vibration1995，186，2： | 1 |
| 17 | Diffusive supersonic X-ray transport in radiatively heated foam cylinders显示文摘 | Back C A Bauer J D Hammer J H | 2000 | Phys Plasmas2000，7，5： | 1 |
| 18 | Selective vulnerability of late oligodendendrocyte progenitors to hypoxia ischemia显示文摘 | BACK S A HAN B H LUO N L | 2002 | J Neurosci2002，22，2： | 1 |
| 19 | Investigation of influence of thermal accom- modation on oscillating micro - flow 显示文摘 | Park J H Back S W | 2004 | International Journal of Heat and Mass Transfer2004，47，6： | 1 |
| 20 | Selective vuln erability of late oligodendrocyte progenitors to hypoxia-is- chemia显示文摘 | BACK S A HAN B H LUO N L | 2002 | J Neurosei2002，22，2： | 1 |
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