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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Characterization of nova plasmas using an X-ray spectrometer with temporal and spatial resolution显示文摘 | BACK C A AUFFMAN R L K BELL P M | 1995 | Review of Scientific Instruments1995，66，1： | 1 |
| 3 | Characterization of Nova plasmas using an x-ray spectrometer with temporal and spatial resolution显示文摘 | Back C A Kauffman R L Bell P M | 1995 | Rev Sci Instrum1995，66，1： | 1 |
| 4 | Multiple pulse electron beam converter design for high power radiography显示文摘 | Pincosy P A Back N Bergstrom P M | 2001 | Review of Scientific Instruments2001，72，6： | 1 |
| 5 | Monovision 显示文摘 | Josephson JE Erickson P Back A Holden BA Harris M Tomlinson A | 1990 | J Am Optom Assoc1990，61，11： | 1 |
| 6 | PHASES score for prediction of intracranial aneurysm growth显示文摘 | Backes D Vergouwen M D Groenestege A T Bor A S Velthuis B K Greving J P | 2015 | Stroke2015，46，： | 1 |
| 7 | Sesquiterpene cyclase is not a determining factor for elicitor and pathogen-induced capsidiol accumulation in tobacco 显示文摘 | Keller H Czernic P Ponchet M Ducrot P H Back K Chappell J | 1998 | Phanta1998，205，： | 1 |
| 8 | Paediatric coblation tonsillectomy显示文摘 | Back L P H Timmms M S | 2001 | Int J pediatr Otorhinolaryngol2001，61，： | 1 |
| 9 | Local recurrence after curative resection of cancer of the rectum without total mesorectal excision显示文摘 | Killing back M Barron P Dent O F | 2001 | Dis Colon Rectum2001，44，4： | 1 |
| 10 | Multiple pulse electron beam converter design for high power radiography显示文摘 | PINCOSY P A BACK N BERGSTROM P M | 2001 | Review of Scientific Instrument2001，72，6： | 1 |
| 11 | Characterization of Nova plasmas using an X-ray spectrometer with temporal and spatial resolution显示文摘 | Back C A Kauffman R L Bell P M | 1995 | Rev Sci Instrum1995，66，1： | 1 |
| 12 | Paediatric coblation tonsillectomy显示文摘 | Back L P H Timmms M S | 2001 | Int J pediatr Otorhinolaryngol2001，61，： | 1 |
| 13 | Disease complexes involving plant parasitic nematodes and soil- borne pathogens 显示文摘 | BACK M A HAYDOCK P P J JENKINSON P | 2002 | Plant Pathol2002，51，6： | 1 |
| 14 | Trypsin- based laboratory methods and carboxypeptidase activation peptide in acute pancreatitis 显示文摘 | Kylanpaa Back M L Kemppainen E Puolakkainen P | 2002 | JOP2002，3，2： | 1 |
| 15 | Role of C-reactive protein in cardiovascular disease显示文摘 | Howard PA Moriarty P M | 2004 | Ann Pharmacother2004，38，1： | 1 |
| 16 | Comparison of Urine Trypsinogen-2 Test Strip with Serum Lipase in the Diagnosis of Acute Pancreatitis显示文摘 | Kylanpaa Back M L Kemppainen E Puolakkainen P | 2002 | Hepato-gast roenterology2002，49，46： | 1 |
| 17 | Disease complexes involving plant parasitic nematodes and soilborne pathogens显示文摘 | BACK M A HAYDOCK P P J JENKINSON P | 2002 | Plant Pathology2002，51，： | 1 |
| 18 | Optimal lipid modifica- tion:the rationale for combination therapy 显示文摘 | Backes J M Gibson C A Howard P A | 2005 | Vasc Health Risk Manag2005，1，4： | 1 |
| 19 | Cerebral arterial contraction after experimental subarachnoid hemorrhage is associated with blood components within the arterial wall 显示文摘 | Liszezak T M Varsos V G Back P M | 1983 | Neruosurg1983，58，1： | 1 |
| 20 | A rapid effect of applied brassinolide on abscisic acid concentra- tions in Brassica napus leaf tissue subjected to short-term heat stress 显示文摘 | KUREPIN L V QADERI M M BACK T G REID D M PHARIS R P | 2008 | Plant Growth Regulation2008，55，3： | 1 |
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