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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Modification of ovalburnin in stored eggs detected by heat denaturation显示文摘 | Smith M B Back J F | | 0，，： | 1 |
| 3 | Multilineage potential of adult human mesenchymal stem sells显示文摘 | Pittenger M F Mackay AM Back SC | 1999 | Science1999，284，5411： | 1 |
| 4 | Dominant designs and the survival of firms显示文摘 | SUAREZ FERNAN DO F SUAREZ JAMES M UTTER- BACK | 1995 | Strategic Management Journal1995，16，6： | 1 |
| 5 | Efficacy of Communication Skills Training for Giving Bad News and Discussing Transitions to Palliative Care显示文摘 | Back A L Arnold R M Baile W F | 2007 | Arch Intern Med2007，167，5： | 1 |
| 6 | Matrix metalloproteinases in atherothrombosis 显示文摘 | Back M Ketelhuth D F Agewall S | 2010 | Prog Cardiovasc Dis2010，52，5： | 1 |
| 7 | Increased thermal stability of proteins in the presence of sugars and polyols 显示文摘 | Back J F Oakenfull D Smith M B | 1979 | Biochemistry1979，18，23： | 1 |
| 8 | Efficacy of communication skills training for giving bad news and discussing transitions to palliative care显示文摘 | Back A L Arnold R M Baile W F | 2007 | Archives of Internal Medicine2007，167，5： | 1 |
| 9 | Local recurrence after curative resection of cancer of the rectum without total mesorectal excision显示文摘 | Killing back M Barron P Dent O F | 2001 | Dis Colon Rectum2001，44，4： | 1 |
| 10 | An ELISA for detection of antibodies against influenza A nucleoprotein in humans and various animal species显示文摘 | De Boer G F Back W Osterhaus A D M E | 1990 | Arch Virol1990，115，： | 1 |
| 11 | Matrix metalloproteinases in atherothrombosis 显示文摘 | Back M Ketelhuth 13 F Agewall S | 2010 | Prog Cardiovasc Dis2010，52，5： | 1 |
| 12 | An ELISA for detection of antibodies against influenza A nucleoprotein in humans and various animal species显示文摘 | DE BOER G F BACK W OSTERHAUS A D M E | 1990 | Arch Virol1990，115，12： | 1 |
| 13 | Influence of Lauter Turbidity on Wort Composition, Fermentation Performance and Beer Quality in Large-Scale Trials 显示文摘 | Kǖhbeck F Back W Krottenthaler M | 2006 | J Inst Brew2006，112，3： | 1 |
| 14 | The Cis-state of an Azobenzene Photoswitch Is Stabilized through Specific Interactions with a Protein Surface显示文摘 | Korbus M Back S Meyer-Almes F J | 2015 | J Mol Recognit2015，28，3： | 1 |
| 15 | Modification of ovalbumin in stored eggs detected by heat denaturation 显示文摘 | SMITH M B BACK J F | 1962 | Nature1962，193，： | 1 |
| 16 | Increased thermal stability of Proteins in the presence of sugars and polyols显示文摘 | BACK J F OAKENFULL D SMITH M B | 1979 | Biochemistry1979，18，23： | 1 |
| 17 | 10-GHz and 20-GHz channel spacing high-resolution AWGs on InP 显示文摘 | Back J H Soares F M Seo S W | 2009 | IEEE Photonics Technology Letters2009，21，5： | 1 |
| 18 | Increased urinary leukotriene E4 excrelion in obstructive sleep apnea: ef- fects of obesity and hypoxia 显示文摘 | Stanke-Labesque F Back M Lefebvre B | 2009 | J Allergy Clin Immunol2009，124，2： | 1 |
| 19 | Approaching difficult communication tasks in oncology显示文摘 | Back A L Arnold R M Baile W F | 2005 | CA Cancer J Clin2005，55，3： | 1 |
| 20 | Novel potent macrocyclic inhibitors of the hepatitis C virus NS3 protease: use of cyclopentane and cyclopentene P2-motifs 显示文摘 | Back M Johansson PO Wangsell F | 2007 | Bioorg Med Chem2007，15，22： | 1 |
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