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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Modification of ovalburnin in stored eggs detected by heat denaturation显示文摘 | Smith M B Back J F | | 0，，： | 1 |
| 3 | ^1H MR Spectroscopy of the brain: absolute quantification of metabolites显示文摘 | Jacobus J F Backes W H Nicolay K | 2006 | Radiology2006，240，2： | 1 |
| 4 | ^1H MR spectroscopy of the brain:absolute quantification of metabolites显示文摘 | Jansen J F Backes W H Nicolay K | 2006 | Radiology2006，240，2： | 1 |
| 5 | Auctions of divisible goods显示文摘 | Back K Zender J F | | 0，，06： | 1 |
| 6 | lH MR spectroscopy of the brain:absolute quantification of metabolites显示文摘 | Jansen J F Backes W H Nicolay K | 2006 | Radiology2006，240，2： | 1 |
| 7 | Allergens in the white and yolk of hen's egg: a study of IgE binding by egg proteins显示文摘 | ANET J BACK J F BACKER R S | 1985 | Int Arch Allergy Appl Immunol1985，77，3： | 1 |
| 8 | Auctions of divisible goods with endogenous supply显示文摘 | BACK K ZENDER J F | 2001 | Economics Letters2001，，73： | 1 |
| 9 | Increased thermal stability of proteins in the presence of sugars and polyols 显示文摘 | Back J F Oakenfull D Smith M B | 1979 | Biochemistry1979，18，23： | 1 |
| 10 | Features of the formate dehydrogenase mRNA necessary for decoding of the UGA codon as selenocysteine显示文摘 | Zinont F Heidor J Back A | 1990 | Proc Natl Acad Sci USA1990，87，： | 1 |
| 11 | Enhanced bone formation in lipodystrophic PPARgamma(hyp/hyp) mice relocates haematopoiesis to the spleen显示文摘 | Cock TA Back J Elefteriou F | | 0，，： | 1 |
| 12 | Cyclosporin metabolism by the gastrointestinal mucosa显示文摘 | Webber I R Back D J | 1991 | Br J Clin Pharmacol1991，31，3： | 1 |
| 13 | Electronic Space Fire Protection: False Deck Mockup Fire Testing of Nanomist Systems显示文摘 | Adiga K C Hatcher R F Jr Forsell E W Scheffy J L DiNenno P J Back G G Farley J P Williams F W | 2005 | 15th Annual International Halon Options Technical Working Conference (HOTWC) Albuquerque NM2005，，： | 1 |
| 14 | Auctions of divisible goods显示文摘 | Back K Zender J F | 1993 | Review of Financial Studies1993，，73： | 1 |
| 15 | Auctions of Divisible Goods: On the Rationale for the Treasury Experiment 显示文摘 | Back K Zender J F | 1993 | Review of Financial Studies1993，，6： | 1 |
| 16 | Auctions of divisible goods: on the rationale for the treasury experiment 显示文摘 | Back K Zender J F | 1993 | Review of Financial Studies1993，6，： | 1 |
| 17 | The Cis-state of an Azobenzene Photoswitch Is Stabilized through Specific Interactions with a Protein Surface显示文摘 | Korbus M Back S Meyer-Almes F J | 2015 | J Mol Recognit2015，28，3： | 1 |
| 18 | Modification of ovalbumin in stored eggs detected by heat denaturation 显示文摘 | SMITH M B BACK J F | 1962 | Nature1962，193，： | 1 |
| 19 | Increased thermal stability of Proteins in the presence of sugars and polyols显示文摘 | BACK J F OAKENFULL D SMITH M B | 1979 | Biochemistry1979，18，23： | 1 |
| 20 | 10-GHz and 20-GHz channel spacing high-resolution AWGs on InP 显示文摘 | Back J H Soares F M Seo S W | 2009 | IEEE Photonics Technology Letters2009，21，5： | 1 |
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