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| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 3 | The effect of postoperative wound infections on functional outcome following intra-articular calcaneal fractures显示文摘 | Backes M Schep N W Luitse J S | 2015 | Archives of Orthopaedic&Trauma Surgery2015，135，8： | 1 |
| 4 | Traditional tonsillectomycompared with bipolar radiofrequency thermal ablationtonsillectomy in adults: a pilot study 显示文摘 | Back L Paiolheimo M Ylikoski J | 2001 | Arch Otolaryngol HeadNeck Surg2001，127，： | 1 |
| 5 | Study on the membrane filtration of mash with particular respect to the quality of wort and beer显示文摘 | Schneider J Krottenthaler M Back W | 2005 | Journal of the Institute of Brewing2005，111，4： | 1 |
| 6 | Constitutively wilted 1,a member of the rice YUCCA gene family,is required for maintaining water homeostasis and an appropriate root to shoot ratio显示文摘 | Woo Y M Park H J Su'udi M Yang J I Park J J Back K Park Y M An G | 2007 | Plant Molecular Biology2007，65，1： | 1 |
| 7 | A review of convention and meeting management research 1990 - 2003 显示文摘 | Lee M J Back K J | 2005 | Journal of Convention & Event Tourism2005，7，2： | 1 |
| 8 | Modification of ovalburnin in stored eggs detected by heat denaturation显示文摘 | Smith M B Back J F | | 0，，： | 1 |
| 9 | Resveratrol:A review of preclinical studies for human cancer prevention显示文摘 | Athar M Back J H Tang X W | 2007 | Toxicology and Applied Pharmacology2007，224，3： | 1 |
| 10 | CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses显示文摘 | Zhang T Kohlhaas M Backs J | 2007 | J Biol Chem2007，282，35： | 1 |
| 11 | Tissue expression and cellular localization of phospholipid hydroperoxide glutathione peroxidase (PHGPx) mRNA in male mice显示文摘 | Back I J Seo D S Yon J M | 2007 | J Mol Histol2007，38，3： | 1 |
| 12 | Endothelin-1 inhibits the neuronal norepinephrine transporter in hearts of male rats 显示文摘 | Backs J Bresch E Lutz M | 2005 | Cardiovasc Res2005，67，2： | 1 |
| 13 | Two-year field study shows little evidence that PPO-transgenic rice affects the structure of soil microbial communities显示文摘 | Chun Y J Kim H J Park K W Jeong S C Lee B Back K Kim H M and Kim C G | | 0，，： | 1 |
| 14 | Submucosal bipolar radiofrequency thermal ablation of inferior turbinates:a long term follow-up with subjective and objective assessment显示文摘 | Back L J Hytonen M L Malmberg H O | 2002 | Laryngoscope2002，112，10： | 1 |
| 15 | Viral host-range factor C7 or K1 is essential for modified vaccinia virus Anka- ra late gene expression in human and murine cells, irrespec- tive of their capacity to inhibit protein kinase R-mediated phosphorylation of eukaryotic translation initiation factor 2alpha 显示文摘 | Backes S Sperling K M Zwilling J | 2010 | J Gen Virol2010，91，2： | 1 |
| 16 | Traditional tonsillectomy compared with bipolar radiofrequency thermal ablation tonsillectomy in adults: a pilot study 显示文摘 | BACK L PALOHEIMO M YLIKOSKI J | 2001 | Arch Otolaryngol Head Neck surg2001，127，： | 1 |
| 17 | Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase显示文摘 | STARKS C M BACK K CHAPPELL J | 1997 | Science1997，277，： | 1 |
| 18 | Resveratrol: a review of preclinical studies for human cancer prevention显示文摘 | Athar M Back J H Tang X W | 2007 | Toxicol Appl Pharmacol2007，224，3： | 1 |
| 19 | Expression of survivin and clinical correlation in patients with breast cancer 显示文摘 | Sohn D M Kim S Y Back M J | 2006 | Biomed Pharmacother2006，60，6： | 1 |
| 20 | Multiple molecular targets of resveratrol: Anti-carcinogenic mechanis- ms显示文摘 | ATHAR M BACK J H KOPELOVICH L | 2009 | Archives of Biochemistry and Biophysics2009，486，2： | 1 |
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