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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | The immunohistochemical overexpression of ribonucleotide reductase regulatory subunit M1 ( RRMI ) protein is a predictor of shorter survival to gemcitabine-based chemotherapy in advanced non-small cell lung cancer (NSCLC)显示文摘 | Lee J J Maeng C H Back S K | 2010 | Lung Cancer2010，70，2： | 1 |
| 3 | Analysis of heavy-ion fusion reactions at extreme sub-barrier energies显示文摘 | Jiang C L Esbensen H Back B B | 2004 | Phys Rev C2004，69，14： | 1 |
| 4 | Volatile components in flavour concentrates from crayfish processing waste显示文摘 | Cha Y J Back H H Hsieh T C Y | 2006 | Journal of the Science of Food and Agriculture2006，58，2： | 1 |
| 5 | Diffusive supersonic X-ray transport in radiatively heated foam cylinders显示文摘 | Back C A Bauer J D Hammer J H | 2000 | Phys Plasmas2000，7，5： | 1 |
| 6 | Two-year field study shows little evidence that PPO-transgenic rice affects the structure of soil microbial communities显示文摘 | Chun Y J Kim H J Park K W Jeong S C Lee B Back K Kim H M and Kim C G | | 0，，： | 1 |
| 7 | 显示文摘 | Back D H Ki C S Um I C | 2007 | Fibers and Polymers2007，8，3： | 1 |
| 8 | Experimental in vestigation of electrostatic dispersion and combustion of diesel fuel jets显示文摘 | Bankston C P Back H L Kwack E Y | | 0，，03： | 1 |
| 9 | Experimental inves-tigation of electrostatic dispersion and combustion of diesel fuel jets显示文摘 | Bankston C P Back H L Kwaek E Y | 1988 | Journal of Engineering for Gas Turbines and Power-Transactions of the ASME1988，110，3： | 1 |
| 10 | Diffusive, supersonic X-ray transport in radiatively heated foam cylinders显示文摘 | Back C A Bauer J D Hammer J H | 2000 | Physics of Plasmas2000，7，5： | 1 |
| 11 | Membrane delimited coupling of TRPV 1 and mGluR 5 on presynaptie terminals of nociceptiveneurons显示文摘 | Kim Y H Park C K Back S K | 2009 | J Neurosci2009，29，10： | 1 |
| 12 | Diffusive,supersonic X-ray transport in radiatively heated foam cylinders显示文摘 | Back C A Bauer J D Hammer J H | 2000 | Phys Plasmas2000，7，5： | 1 |
| 13 | Ultrafast generation of magnetic fields in a Schottky diode显示文摘 | ACREMANN Y BUESS M BACK C H | 2001 | Nature2001，414，6859： | 1 |
| 14 | Studies on the oxidation of pyrite in colliery spoil: Inhibition of the oxidation by amendment treatments 显示文摘 | Backes C A Pulford I D Duncan H J | 1987 | Recl and Reveg Res1987，，6： | 1 |
| 15 | Anti-diarrheal and spasmolytic activities and acute toxicity study of Soonkijangqucbo, a herbal anti-diarrheal formula 显示文摘 | Ryu S D Park C S Back H M | 2004 | Journal of Ethnopharmacology2004，91，1： | 1 |
| 16 | I I guidelines of prevention of atherosclerosis in childhood and adolescence] 显示文摘 | Back Giuliano Ide C Caramelli B Pellanda L Duncan B Mattos S Fonseca F H Sociedade Brasileira de Cardiologia | 2005 | Arq Bras Cardiol2005，856，： | 1 |
| 17 | Aroma extract dilution analysis of a beeflike process flavor from extruded enzyme- hydrolyzed soybean protein显示文摘 | Back H H Kim C J Ahn B H | 2001 | Agrie Food Chem2001，49，： | 1 |
| 18 | Isoelectronic x-ray spectroscopy to determine electron temperatures in long-scale-length inertial-confinement-fusion plasmas显示文摘 | Shepard T D Back C A Kalantar D H | 1996 | Phys Rev1996，53，5： | 1 |
| 19 | The perilobule approach to subcondylar fractures显示文摘 | Back R M Min K H Hen C Y | | 0，，03： | 1 |
| 20 | Effects of saponin contained plant extracts on ruminal fermentation characteristics and methane production显示文摘 | Ok J U Back Y C Kim K H | 2011 | Anim Feed Sci Tech2011，53，2： | 1 |
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