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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Constitutively wilted 1,a member of the rice YUCCA gene family,is required for maintaining water homeostasis and an appropriate root to shoot ratio显示文摘 | Woo Y M Park H J Su'udi M Yang J I Park J J Back K Park Y M An G | 2007 | Plant Molecular Biology2007，65，1： | 1 |
| 3 | Reactivity of alkaline lignite fly ashes towards CO2 in water 显示文摘 | Back M Kuehn M Stanjek H | 2008 | Environmental Science and Technology2008，42，12： | 1 |
| 4 | Urine alhumin/creatinine ratio for the assessment of albuminuria in pregnancy hyperten- siom显示文摘 | Nisell H Trygg M Back R | 2006 | Acta Obstet Gynecol Scand2006，85，11： | 1 |
| 5 | Resveratrol:A review of preclinical studies for human cancer prevention显示文摘 | Athar M Back J H Tang X W | 2007 | Toxicology and Applied Pharmacology2007，224，3： | 1 |
| 6 | ER stress signaling by regulated splicing: IREI/HAC1/XBPI显示文摘 | BACK S H SCHRODER M LEE K | 2005 | Methods2005，35，4： | 1 |
| 7 | Two-year field study shows little evidence that PPO-transgenic rice affects the structure of soil microbial communities显示文摘 | Chun Y J Kim H J Park K W Jeong S C Lee B Back K Kim H M and Kim C G | | 0，，： | 1 |
| 8 | Submucosal bipolar radiofrequency thermal ablation of inferior turbinates:a long term follow-up with subjective and objective assessment显示文摘 | Back L J Hytonen M L Malmberg H O | 2002 | Laryngoscope2002，112，10： | 1 |
| 9 | Resveratrol: a review of preclinical studies for human cancer prevention显示文摘 | Athar M Back J H Tang X W | 2007 | Toxicol Appl Pharmacol2007，224，3： | 1 |
| 10 | Multiple molecular targets of resveratrol: Anti-carcinogenic mechanis- ms显示文摘 | ATHAR M BACK J H KOPELOVICH L | 2009 | Archives of Biochemistry and Biophysics2009，486，2： | 1 |
| 11 | Combined QRD-M and DFE detection technique for simple and efficient signal detection in MIMO-OFDM systems显示文摘 | Back M S You Y H Song H K | 2009 | IEEE Transactions on Wireless Communication2009，8，4： | 1 |
| 12 | Antagonist resistant contractions of theporcine pulmonary artery by cysteinyl-leukotrienes显示文摘 | Back M Norel X Walch h | 2000 | Eur J Pharma-col2000，401，3： | 1 |
| 13 | Submocosal Bipolar Radiofrequency Thermal Ablation of Inferior Turbinates:a Long-term Follow-up with Subjective and Objective Assessment显示文摘 | Back L J Hytonen M L Malmberg H O | 2002 | Laryngoscope2002，112，： | 1 |
| 14 | Construction of bacterial artificial chromosome library from electrochemical microorganisms显示文摘 | Back J H Kim M S Cho H | 2004 | Fems Microbiol Lett2004，238，： | 1 |
| 15 | Urine albumin/creatinine ratio for the assessment of albuminuria in pregnancy hypertension 显示文摘 | Nisell H Trygg M Back R | 2006 | Acta Obstet Gynecol Scand2006，85，11： | 1 |
| 16 | Freeze-thaw stabilization of sweet potato starch gel by polysaccharide gums显示文摘 | Lee M H Back M H Cha D S | 2002 | Food Hydrocolloids2002，16，： | 1 |
| 17 | Novel analytical tools for food flavours 显示文摘 | Stephan A Backing M Steinhart H | 2000 | Food Research International2000，33，2： | 1 |
| 18 | Resveratrol: A review of preclinical studies for human cancer prevention显示文摘 | Athar M Back J H Tang X | 2007 | Tox Appl Pharm2007，224，： | 1 |
| 19 | Sesquiterpene cyclase is not a determining factor for elicitor and pathogen-induced capsidiol accumulation in tobacco 显示文摘 | Keller H Czernic P Ponchet M Ducrot P H Back K Chappell J | 1998 | Phanta1998，205，： | 1 |
| 20 | Urine albumin/creatinine ratio for the assessment of albuminuria in pregnancy hypertension显示文摘 | Nisell H Trygg M Back R | 2006 | Acta Ac- ta Obstet Gynecol Scand2006，85，11： | 1 |
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