|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 2 | 白质内的神经递质信号显示文摘脑白质是由许多有髓鞘的轴突组成,白质和灰质共同组成中枢神经系统,白质是中枢神经系统内信息快速传递的基础。有髓神经通路主要是由少突胶质细胞、星形胶质细胞及少量的小胶质细胞和少突胶质前体细胞构成。大部分白质内的神经递质信号主要存在于神经细胞胞体外,这提示这些神经递质除了具有完成神经元与神经元之间信息传递的功能外,还有其他生理功能。白质中的神经递质信号种类很多,已经证实的有谷氨酸能、嘌呤能(ATP和腺苷)、GABA能、甘氨酸能、肾上腺素能、胆碱能、多巴胺能、血清素能等信号递质,通过与各种离子型或代谢型受体结合发挥作用。轴突和胶质细胞都可以释放神经递质,也可以表达相应的受体。白质内神经递质信号的生理功能还需进一步研究,但研究已经证实谷氨酸和ATP介导的信号可激活胶质细胞上的钙离子通道,并调节轴突的传导功能。某项研究显示,在动作电位传播的过程中,轴突释放神经递质并与胶质细胞上的受体结合,通过少突胶质细胞来调节星形胶质细胞的稳态和髓鞘形成。星形胶质细胞也释放神经递质,与轴突上的受体相结合,增强动作电位的传播,维持信号电位沿长的轴突传播。白质内神经递质种类的多样性,提示它们有多种功能,对信号的传递有重要作用。白质内的神经递质信号现象很有可能也存在于大脑皮质和灰质,在这些部位的神经递质对于大脑的高级认知功能有更重要的作用。 | Butt AM Fern RF Matute C 唐颖馨 | 2014 | 神经损伤与功能重建2014，9，6： | 2 |
| 3 | Cells Expressing the NG2 Antigen Contact Nodes of Ranvier in Adult CNS White Matter 显示文摘 | BUTT AM DUNCAN A HORNBY MF | 1999 | Gila(S0894-4191)1999，26，1： | 1 |
| 4 | Neurotransmitter-mediated calcium signaling in oligodendrocyte physiology and pathology 显示文摘 | Butt AM | 2006 | Glia2006，54，7： | 1 |
| 5 | Parallel expressionprofiling of hepatic and serum microRNA - 122 associatedwith clinical features and treatment responses in chronic hep-atitis C patients显示文摘 | BUTT AM RAJA AJ SIDDIQUE S | 2016 | Sci Rep2016，6，21： | 1 |
| 6 | Neurotransmitter-mediated calcium signaling in oligodendrocyte physiology and pathology显示文摘 | Butt AM | 2006 | Glia2006，54，7： | 1 |
| 7 | Neurotransmitter-mediated calcium signalling in oligodendrocyte physiology and pathology显示文摘 | Butt AM | | 0，，07： | 1 |
| 8 | Expression of GABA transporter RNAs in the deveoping and adult rat optic nerve显示文摘 | Howd AG Rattray M Butt AM | 1997 | Neurosci Letters1997，235，： | 1 |
| 9 | Is depression an inflammatory con- dition? A review of available evidence 显示文摘 | Hashmi AM Butt Z Umair M | 2013 | J Pak Med Assoc2013，63，： | 1 |
| 10 | Neurotransmitter-mediated calcium signaling in oligodendrocyte physiology and pathology 显示文摘 | Butt AM | 2006 | Glia2006，54，7： | 1 |
| 11 | Synantocytes: the fifth element 显示文摘 | Butt AM HamiltonN Hubbard P | 2005 | J Anat2005，207，： | 1 |
| 12 | Expression profiling ofserum microRNA - 101 in HBV - associated chronic hepati-tis, liver cirrhosis, and hepatocellular carcinoma显示文摘 | XIE Y YAO QW BUTT AM | 2014 | CancerBiol Ther2014，15，9： | 1 |
| 13 | The fate of ingested enzymes in cystic fibrosis显示文摘 | Butt AM Ip W ELLIS L | 2001 | Pediatr Pulm2001，，： | 1 |
| 14 | ATP: a ubiquitous gliotransmitter integrating neu-ron-glial networks 显示文摘 | Butt AM | 2011 | Semin Cell Dev Biol2011，22，2： | 1 |
| 15 | Postnatal switch from synaptic to extrasynaptic transmission between interneurons and NG2 cells显示文摘 | V61ez-Fort M Maldonado PP Butt AM | 2010 | J Neurosci2010，30，： | 1 |
| 16 | ATP: a ubiquitous gliotransmitter integrating neuron-glial networks显示文摘 | Butt AM | 2011 | Semin Cell Dev Biol2011，22，2： | 1 |
| 17 | P2X and P2Y purinoreceptors mediate ATP-evoked calcium signalling in optic nerve glia in situ显示文摘 | James G Butt AM | | 0，，： | 1 |
| 18 | Integration of NG2-glia (synantocytes) into the neuroglial network显示文摘 | Wigley R Butt AM | | 0，，1： | 1 |
| 19 | Evidence that perinatal and adult NG2-glia are not conventional oligodendrocyte progenitors and do not depend on axons for their survival显示文摘 | Greenwood K Butt AM | | 0，，04： | 1 |
| 20 | Synantocytes: New Functions for Novel NG2 Expressing Glia显示文摘 | Butt AM Kiff J Hubbard P | 2002 | J Neurocytol(S0300-4864)2002，31，67： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员