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| 1 | Defining the advantages and exposing the limitations of endoscopic variceal ligation in controlling acute bleeding and achieving complete variceal eradication显示文摘BACKGROUND Bleeding esophageal varices(BEV)is a potentially life-threatening complication in patients with portal hypertension with mortality rates as high as 25%within six weeks of the index variceal bleed.After control of the initial bleeding episode patients should enter a long-term surveillance program with endoscopic intervention combined with non-selectiveβ-blockers to prevent further bleeding and eradicate EV.AIM To assess the efficacy of endoscopic variceal ligation(EVL)in controlling acute variceal bleeding,preventing variceal recurrence and rebleeding and achieving complete eradication of esophageal varices(EV)in patients who present with BEV.METHODS A prospectively documented single-center database was used to retrospectively identify all patients with BEV who were treated with EVL between 2000 and 2018.Control of acute bleeding,variceal recurrence,rebleeding,eradication and survival were analyzed using Baveno assessment criteria.RESULTS One hundred and forty patients(100 men,40 women;mean age 50 years;range,21-84 years;Child-Pugh grade A=32;B=48;C=60)underwent 160 emergency and 298 elective EVL interventions during a total of 928 endoscopy sessions.One hundred and fourteen(81%)of the 140 patients had variceal bleeding that was effectively controlled during the index banding procedure and never bled again from EV,while 26(19%)patients had complicated and refractory variceal bleeding.EVL controlled the acute sentinel variceal bleed during the first endoscopic intervention in 134 of 140 patients(95.7%).Six patients required balloon tamponade for control and 4 other patients rebled in hospital.Overall 5-d endoscopic failure to control variceal bleeding was 7.1%(n=10)and four patients required a salvage transjugular intrahepatic portosystemic shunt.Index admission mortality was 14.2%(n=20).EV were completely eradicated in 50 of 111 patients(45%)who survived>3 mo of whom 31 recurred and 3 rebled.Sixteen(13.3%)of 120 surviving patients subsequently had 21 EV rebleeding episodes and 10 patients bled from other sources after discharge from hospital.Overall rebleeding from all sources after 2 years was 21.7%(n=26).Sixty-nine(49.3%)of the 140 patients died,mainly due to liver failure(n=46)during follow-up.Cumulative survival for the 140 patients was 71.4%at 1 year,65%at 3 years,60%at 5 years and 52.1%at 10 years.CONCLUSION EVL was highly effective in controlling the sentinel variceal bleed with an overall 5-day failure to control bleeding of 7.1%.Although repeated EVL achieved complete variceal eradication in less than half of patients with BEV,of whom 62%recurred,there was a significant reduction in subsequent rebleeding. | Jake Krige Eduard Jonas Urda Kotze Christo Kloppers Karan Gandhi Hisham Allam Marc Bernon Sean Burmeister Mashiko Setshedi | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，10： | 10 |
| 2 | Role of radiotherapy in the pre-operative management of carcinoma of the esophagus显示文摘The use of radiotherapy in the management of carcinoma of the esophagus and gastro-esophageal junction has undergone much evolution over the past 2 decades. Advances to define its role have been slow with meta-analyses often providing the most useful data. In spite of this many institutions around the world are divided about the role of radiotherapy in this disease and attribute different roles to radiotherapy based on clinical stage, tumor site and histology. The purpose of this review is to try to define the role of radiotherapygiven our current knowledge base and to review which current and future trials may fill the gaps of knowledge that we currently have. It will also highlight the difficulties in making firm recommendations about the use of radiotherapy especially in a time when technology and treatments are rapidly evolving. | Bryan H Burmeister | 2015 | World Journal of Gastrointestinal Oncology2015，7，1： | 4 |
| 3 | Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis显示文摘 | Katrin M Sjoquist Bryan H Burmeister B Mark Smithers John R Zalcberg R John Simes Andrew Barbour Val Gebski | 2011 | Lancet Oncology2011，，7： | 4 |
| 4 | Cachexia and pancreatic cancer: Are there treatment options?显示文摘Cachexia is frequently described in patients with pancreatic ductal adenocarcinoma(PDAC)and is associated with reduced survival and quality of life.Unfortunately,the therapeutic options of this multi-factorial and complex syndrome are limited.This is due to the fact that,despite extensive preclinical and clinical research,the underlying pathological mechanisms leading to PDAC-associated cachexia are still not fully understood.Furthermore,there is still a lack of consensus on the definition of cachexia,which complicates the standardization of diagnosis and treatment as well as the analysis of the current literature.In order to provide an efficient therapy for cachexia,an early and reliable diagnosis and consistent monitoring is required,which can be challenging especially in obese patients.Although many substances have been tested in clinical and preclinical settings,so far none of them have been proven to have a long-term effect in ameliorating cancer-associated cachexia.However,recent studies have demonstrated that multidimensional therapeutic modalities are able to alleviate pancreatic cancerassociated cachexia and ultimately improve patients’outcome.In this current review,we propose a stepwise and pragmatic approach to facilitate and standardize the treatment of cachexia in pancreatic cancer patients.This strategy consists of nutritional,dietary,pharmacological,physical and psychological methods. | Tara C Mueller Marc A Burmeister Jeannine Bachmann Marc E Martignoni | 2014 | World Journal of Gastroenterology2014，20，28： | 3 |
| 5 | Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies显示文摘 | Sally Wenzel Darren Wilbraham Rick Fuller Elise Burmeister Getz Malinda Longphre | 2007 | The Lancet2007，，9596： | 2 |
| 6 | Apple ripening-related cDNA clone pAP4 confers ethylene-forming ability in transformed Saccharomyces cerevisiae显示文摘 | WILSON I D ZHU Y BURMEISTER D M | 1993 | Plant Physiol1993，102，： | 1 |
| 7 | Improved ceramic-based multisite microelectrode for rapid measurements of L-glutamate in the CNS显示文摘 | BURMEISTER J J POMERLEAU F PALMER M | 2002 | J Neurosci Methods2002，119，2： | 1 |
| 8 | Adherence to ESMO clinical recommendations for prophylaxis of chemotherapy-induced nausea and vomiting显示文摘 | Burmeister H Aebi S Studer C | 2012 | Support Care Cancer2012，20，1： | 1 |
| 9 | 月球粒子辐射环境探测现状显示文摘月球表面没有磁场的保护,粒子辐射是人类在月球活动的重要风险要素。概述了月球的辐射环境以及辐射来源,并介绍了月球探测的现状,特别提及了近年来几个较为典型的月球辐射探测实例及其探测结果;介绍了我国'嫦娥4号'上搭载的月表中子与辐射剂量探测仪(Lunar Lander Neutron&Dosimetry,LND)的科学目标及其技术指标。LND的科学目标主要包括:载人登月辐射剂量的测量、月球南极艾特肯盆地水含量的测量、艾特肯盆地FeO含量的测量,以及为日球层科学的研究提供依据。 | 侯东辉 张珅毅 Robert F Wimmer-Schweingruber 于佳 Soenke Burmeister 沈国红 袁斌 王春琴 张斌全 | 2019 | 深空探测学报2019，6，2： | 1 |
| 10 | Capital deepening kesponse in an economy with heterogeneous capital goods显示文摘 | Burmeister Edwin Tumovshy Stephen J | 1972 | American Economic Review1972，62，5： | 1 |
| 11 | Application of Multi-Agent Systems in Traffic and Transportation显示文摘 | Burmeister B Haddadi A Matylis G | 1997 | IEE Proceedings on Software Engineering1997，144，1： | 1 |
| 12 | Unilateral demodectic rosacea显示文摘 | Shelley ED Burmeister V | 1989 | J Am Acad Dermatol1989，20，： | 1 |
| 13 | Differential roles of 5 - HT receptor subtypes in cue and cocaine reinstatement of cocaine - seeking behavior in rats 显示文摘 | Burmeister J J Lungren EM Kirschner KF | 2004 | Neumpsychopharmacology2004，29，4： | 1 |
| 14 | New insights into the genetics of addiction显示文摘 | Li MD Burmeister M | 2009 | Nat Rev Genet2009，10，4： | 1 |
| 15 | Low ERG and BAALC expression identifies a new subgroup of adult acute T-Iymphoblas?tic leukemia with a highly favorable outcome显示文摘 | Baldus CD Martus P Burmeister T | 2007 | J Clin Oncol2007，25，24： | 1 |
| 16 | Sur-vival after neoadjuvant chemotherapy or chemoradiotherapy for re-sectable oesophageal carcinoma : an updated meta-analysis 显示文摘 | SJOQUIST K M BURMEISTER B H SMITHERS B M | 2011 | Lancet Oncol2011，12，7： | 1 |
| 17 | survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinomma:a meta-analysis显示文摘 | Gebski V Burmeister B smithers BM | 2007 | Lancet Oncol2007，8，： | 1 |
| 18 | Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein(NEP/NS2)显示文摘 | Akarsu H Burmeister W P Petosa C | 2003 | EMBO J2003，22，18： | 1 |
| 19 | Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinai progenitor proliferation and bipolar cell differentiation 显示文摘 | Burmeister M Novak J Liang MY | 1996 | Nat Genet1996，12，4： | 1 |
| 20 | Failure of dietary oligofructose to prevent antibiotic-associated diarrhoea显示文摘 | Lewis S Burmeister S Cohen S | 2005 | Aliment Pharmacol Ther2005，11，： | 1 |
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