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| 1 | Harmful algal blooms and eutrophication: 'strategies' for nutrient uptake and growth outside the Redfield comfort zone显示文摘While many harmful algal blooms have been associated with increasing eutrophication, not all species respond similarly and the increasing challenge, especially for resource managers, is to determine which blooms are related to eutrophication and to understand why particular species proliferate under specific nutrient conditions. The overall goal of this brief review is to describe why nutrient loads are not changing in stoichiometric proportion to the 'Redfield ratio', and why this has important consequences for algal growth. Many types of harmful algae appear to be able to thrive, and/or increase their production of toxins, when nutrient loads are not in proportion classically identified as Redfield ratios. Here we also describe some of the physiological mechanisms of different species to take up nutrients and to thrive under conditions of nutrient imbalance. | Patricia M. GLIBERT JoAnn M. BURKHOLDER | 2011 | Chinese Journal of Oceanology and Limnology2011，29，4： | 21 |
| 2 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 3 | Harmful algal blooms and eutrophication: Nutrient sources, composition, and consequences显示文摘 | Donald M. Anderson Patricia M. Glibert Joann M. Burkholder | 2002 | Estuaries2002，，4： | 4 |
| 4 | Water level variations in the Neuse and Pamlico Estuaries, North Carolina due to local and remote forcing 显示文摘 | Reed R E Dickey D A Burkholder J M | 2008 | Estuarine Coastal and Shelf Science2008，76，2： | 1 |
| 5 | Colorectal carcinomas with high microsatellite instability:defining a distinct immunologic and molecular entity with respect to prognostic markers显示文摘 | Edmonston T B Cuesta K H Burkholder S | | 0，，： | 1 |
| 6 | Eutrophication and harmful algal blooms: A scientific consensus显示文摘 | J. Heisler P.M. Glibert J.M. Burkholder D.M. Anderson W. Cochlan W.C. Dennison Q. Dortch C.J. Gobler C.A. Heil E. Humphries A. Lewitus R. Magnien H.G. Marshall K. Sellner D.A. Stockwell D.K. Stoecker M. Suddleson | 2008 | Harmful Algae2008，，1： | 1 |
| 7 | Pretreatment vascular endothelial growth factor(VEGF) and matrix metalloproteinase-9(MMP-9) serum levels in patients with metastatic non-small cell lung cancer(NSCLC)显示文摘 | Laack E Scheffler A Burkholder I | 2005 | Lung Cancer2005，50，1： | 1 |
| 8 | Characterization of the affinity for nitrogen,uptake kinetics,and environmental relationships for Prorocentrum minimum in natural blooms and laboratory cultures显示文摘 | FAN C GLIBERT P M BURKHOLDER J M | 2003 | Harmful Algae2003，2，： | 1 |
| 9 | Harmful algal blooms and eutrophication: Examining linkages from selected coastal regions of the United States显示文摘 | Donald M. Anderson Joann M. Burkholder William P. Cochlan Patricia M. Glibert Christopher J. Gobler Cynthia A. Heil Raphael M. Kudela Michael L. Parsons J. E. Jack Rensel David W. Townsend Vera L. Trainer Gabriel A. Vargo | 2008 | Harmful Algae2008，，1： | 1 |
| 10 | Overview of the physiological ecology of carbon metabolism in seagrasses 显示文摘 | Touchette B W Burkholder J A M | 2000 | J Exp Mar Biol Ecol2000，250，： | 1 |
| 11 | Structural analysis of substrate binding by the molecular chaperone DnaK显示文摘 | Zhu X Zhao X Burkholder W F | 1996 | Science1996，272，2126： | 1 |
| 12 | The solubilities of lanthanum chloride7-hydrate and lanthanum chloride 6-hydrate in water,and a study of the thermal decomposition of hydrated lanthanum chloride显示文摘 | Powell J E Burkholder H R | 1960 | Journal of Inorganic and Nuclear Chemistry1960，14，1： | 1 |
| 13 | Hedgehog signalling within airway epithelial progenitors and in small-cell lung Cancer显示文摘 | Watkins DN Berman DM Burkholder SG | | 0，，6929： | 1 |
| 14 | 60 GHz in- door propagation studies for wireless communications based on a ray-tracing method显示文摘 | LIM C P LEE M BURKHOLDER R J | 2007 | EURASIP Journal on Wireless Communications and Networking2007，，1： | 1 |
| 15 | Application of prebiotics and probiotics in poultry nutrition显示文摘 | Patterson J A Burkholder K M | 2003 | Pouh Sci2003，82，： | 1 |
| 16 | Impacts to a coastal river and estuary from rupture of a large swine waste holding lagoon显示文摘 | Burkholder J M Mallin M A Glasgow H B | 1997 | Journal of Environmental Quality1997，26，6： | 1 |
| 17 | Analysis of aggregation response in Trogoderma grablumlarvae显示文摘 | Nara J M Lindsay R C Burkholder W E | 1981 | J Agri Food Chem1981，29，： | 1 |
| 18 | The effect of steam flaked or dry ground corn and supplemental phytic acid on nitrogen partitio- ning in lactating cows and ammonia emission from manure 显示文摘 | BURKHOLDER K M GUYTON A D MCK1NNEY J M | 2004 | Journal of Dairy Science2004，87，8： | 1 |
| 19 | Solid state coordinationchemistry:one-,two-,and three-dimensional materials constructed from molybdophosphonatesubunits linked through binuclear copper tetra-2-pyridylpyrazine groups显示文摘 | Burkholder E Golub V O'Connor C J | 2003 | Inorg Chem2003，42，： | 1 |
| 20 | Harmful algal blooms and eutrophication:Nutrient sources,composition,and consequences显示文摘 | ANDERSON D M GLIBERT P M BURKHOLDER J M | 2002 | Estuaries2002，25，4： | 1 |
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