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| 1 | Local immunotherapy with interleuk in-2 delivered from biodegradable p olymer microspheres combined with interstitial chemotherapy:a novel treatme nt for experimental malignant glioma显示文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradable polymers prolon gs survival against experimental brain tumors.Moreover,paracrine administration of inte rleukin-2(IL-2)has been shown to elicit a potent antitumor immune response and to improve survival in animal brain tumor models.We r eport the use of a novel polymeric mic rosphere delivery vehicle to release IL-2.We demonstr ate both in vitro release of cytokine from the microspheres and histological evidence of the inflammatory response elicited by I L-2released from the microspheres i n the rat brain.These microspheres a re used to deliver IL-2,and biodegradable polymer wafers are used to deliver BCNU,directly at the site of an intracranially implanted glioma in the rat.The two agents administered locally show a s ynergistic effect.METHODS:Fischer 344rats challenged intracranially with 9L gliosarcoma received an intracranial implant of either empty microspheres or microspheres containing IL-2(IL-2MS ).Five days later,animals in each group were randomized to receiv e polymer implants loaded with 0,3.8,or 10%BCNU at the tumor site.RESULTS:Animals that received the combination of IL-2MS a nd 3.8%BCNU polymer(median survival,28.5d )or IL-2MS and 10%BCNU polymer(median survival,45.5d )showed significantly improved surv ival compared with animals that rece ived monotherapy with IL-2microsph eres(median survival,24d ),3.8%BCNU polymer(median survival,24d ),or 10%BCNU polymer(median survival,32.5d ).Control animals had a median survival of 18days.The combination of either 3.8or 10%BCNU polymer with IL-2MS resulted in 7and 25%long-term survivors,respectively.CONCLUSION:By showing synergy of IL-2and BCNU in an animal glioma model and using a reproducible synthetic delivery sy stem for each agent (i.e.,one that did not rely on genetic ally engineered cells or viruses),we hope that the combination of local immunotherapy and chemotherapy can take an important step closer to clinical applic ation in patients with malignant brain | Rhines LD DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H | 2003 | 癌症2003，22，7： | 2 |
| 2 | Experimental comparison of biomass chars with other catalysts for tar reduction显示文摘 | El-Rub Abu Z Bramer E A Brem G | 2008 | Fuel2008，87，1011： | 1 |
| 3 | Advancing the field of drug delivery: taking aim at cancer 显示文摘 | Moses M A Brem H Langer R | 2003 | Cancer Cell2003，4，5： | 1 |
| 4 | In Vivo Versus in vitro Degradation of Controlled Release Polymers for Intracranial Surgical Therapy显示文摘 | Wu M P Tamada J A Brem H | 1994 | J Biomed Mater Res1994，28，： | 1 |
| 5 | Fundamentals, kinetics and endothenlticity of the biomass pyrolysis reaction显示文摘 | VAN DE VELDEN M BAEYENS J BREMS A JANSSENS B DEWIL R | 2010 | Renew Energy2010，35，1： | 1 |
| 6 | Experimental comparison of biomass chars with other catalysts for tar reduction显示文摘 | Abu EL-RUB Z BRAMER E A BREM G | 2008 | Fuel2008，87，1011： | 1 |
| 7 | Stroma-conditioned media improve expansion of human primitive hematopoietic stem cells显示文摘 | Brems D A Bloklandd E A W | 1997 | Leukemia1997，90，： | 1 |
| 8 | Experimental comparison of biomass chars with other catalysts for tar reduction显示文摘 | Abu El-Rub Z Bramer E A Brem G | 2008 | Fuel2008，87，10： | 1 |
| 9 | Integration of market pull and technology push in the corporate front end and innovation management-Insights from the German software industry 显示文摘 | Brem A Voigt K I | 2009 | Technovation2009，29，： | 1 |
| 10 | Magnetic force microscopy study of the training effect in polycrystalline Co/CoO bilayers 显示文摘 | Brems S Volodin A Van Haesendonck C | 2008 | J Appl Phys2008，103，11： | 1 |
| 11 | Interstitial chemotherapy with drug polymer imp lants for the treatment of recurrent gliomas显示文摘 | Brem H Mahaley M S Jr Vick N A | 1991 | J Neurosurg1991，74，3： | 1 |
| 12 | Functional analy- sis of yersiniabactin transport genes of Yersinia enterocolitica 显示文摘 | BREM D PELLUDAT C RAKIN A | 2001 | Microbiology2001，147，11： | 1 |
| 13 | Immunolocalization of basic fibroblast growth factor to the microvasculature of human brain tumors显示文摘 | Brem S Tsanaclis A M Gately S | 1992 | Cancer1992，70，11： | 1 |
| 14 | Review of catalysts for tar elimination in biomass gasification processes显示文摘 | ZIAD A E BRAMMER E A BREM G | 2004 | Ind Eng Chem Res2004，43，22： | 1 |
| 15 | Interstitial chemo therapy with drug polymer implants for the treatment of recurrent gliomas显示文摘 | BREM H MAHALTY M S NICHOLAS A V | 1991 | J Neurosurg1991，74，6： | 1 |
| 16 | Integration of market pull and technology push in the corporate front end and innovation management-Insights from the German software industry显示文摘 | Brem A Voigt K | | 0，，05： | 1 |
| 17 | Amanita poisoning treatment and the role of transplantation显示文摘 | Klein A S Hart J Brems J J | 1989 | Am J Med1989，86，： | 1 |
| 18 | Experimental comparison of biomass chars with other catalysts for tar reduction 显示文摘 | EI-RUB Z A BRAMER E A BREM G | 2008 | Fuel2008，87，1011： | 1 |
| 19 | How mueh reducing sugar may potatoes contain to avoid excessive aerylamide formation during roasting baking 显示文摘 | Biedermann - Brem S Noti A Greb K | 2003 | Eur Food Res Teehnol2003，217，5： | 1 |
| 20 | Storage of potatoes at low temperature should be avoided to prevent increased acrylamide formation during frying or roasting 显示文摘 | Noti A Biedermann - Brem S Biedermann M | 2003 | Mitteilungen aus Lebensmitteluntersuchung und Hygiene2003，94，： | 1 |
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