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| 1 | Sympathetic nervous system activation and heart failure:Current state of evidence and the pathophysiology in the light of novel biomarkers显示文摘Heart failure(HF)is a complex clinical syndrome characterized by the activation of at least several neurohumoral pathways that have a common role in maintaining cardiac output and adequate perfusion pressure of target organs and tissues.The sympathetic nervous system(SNS)is upregulated in HF as evident in dysfunctional baroreceptor and chemoreceptor reflexes,circulating and neuronal catecholamine spillover,attenuated parasympathetic response,and augmented sympathetic outflow to the heart,kidneys and skeletal muscles.When these sympathoexcitatory effects on the cardiovascular system are sustained chronically they initiate the vicious circle of HF progression and become associated with cardiomyocyte apoptosis,maladaptive ventricular and vascular remodeling,arrhythmogenesis,and poor prognosis in patients with HF.These detrimental effects of SNS activity on outcomes in HF warrant adequate diagnostic and treatment modalities.Therefore,this review summarizes basic physiological concepts about the interaction of SNS with the cardiovascular system and highlights key pathophysiological mechanisms of SNS derangement in HF.Finally,special emphasis in this review is placed on the integrative and up-to-date overview of diagnostic modalities such as SNS imaging methods and novel laboratory biomarkers that could aid in the assessment of the degree of SNS activation and provide reliable prognostic information among patients with HF. | Josip Anđelo Borovac Domenico D'Amario Josko Bozic Duska Glavas | 2020 | World Journal of Cardiology2020，12，8： | 14 |
| 2 | TKA术后慢性假体周围感染治疗策略的思考——应用决策分析法在一期和二期全膝翻修术中寻找最佳策略显示文摘随着全膝关节置换术(total knee arthroplasty,TKA)手术量的逐年增加,术后假体周围感染(periprosthetic joint infection,PJI)受到越来越多的关注。尽管二期翻修手术被认为是治疗PJI 的金标准,但术后仍有很高的再发率和死亡率。与之相比,一期翻修手术死亡率更低,患者术后生活质量更高。如何在两种术式之间做出选择,需要综合考虑感染控制效果、健康效用以及费用支出等情况。本研究目的在于全面分析TKA术后PJI 的治疗措施,运用决策分析法明确最佳的治疗策略。 | Srivastava K Bozic KJ Silverton C 李昌钊(摘译) 李凭跃(审校) | 2019 | 中国骨科临床与基础研究杂志2019，11，1： | 6 |
| 3 | Inactive matrix Gla protein is elevated in patients with inflammatory bowel disease显示文摘BACKGROUND Matrix Gla protein(MGP)is a vitamin K dependent peptide which has an established role in suppression of vascular calcification.Recent studies have pointed to a possible link between immunomodulatory effect of MGP and inflammatory bowel disease(IBD).AIM To compare plasma levels of dephosphorylated and uncarboxylated MGP(dpucMGP)between IBD patients and controls.METHODS This cross-sectional study was conducted on 70 patients with IBD(30 patients with ulcerative colitis and 40 patients with Crohn’s disease)and 60 age and gender matching healthy controls.Plasma dp-ucMGP levels were analyzed from blood samples by CLIA method using IDS-iSYS InaKtif MGP(Immunodiagnostic Systems,Frankfurt,Germany)according to the manufacturer's instructions.fecal calprotectin(FC)levels were determined from stool samples by turbidimetric immunoassay method using Bühlmann fecal calprotectin turbo assay(Bühlmann Laboratories Aktiengesellschaft,Schonenbuch,Switzerland).Other parameters were analyzed according to the standard laboratory procedures.RESULTS Plasma levels of dp-ucMGP were significantly higher in patients with IBD compared to the healthy control group(629.83±124.20 pmol/mL vs 546.7±122.09 pmol/mL,P<0.001),and there was no significant difference between patients with Crohn’s disease and patients with ulcerative colitis(640.02±131.88 pmol/mL vs 616.23±113.92 pmol/mL,P=0.432).Furthermore,a significant positive correlation of plasma dp-ucMGP levels was found with both FC levels(r=0.396,P<0.001)and high sensitivity C-reactive protein(hsCRP)levels(r=0.477,P<0.001).Moreover,in the total study population a significant positive correlation was found between dp-ucMGP with age(r=0.210,P=0.016)and waist circumference(r=0.264,P=0.002).Multiple linear regression analysis showed that dp-ucMGP levels retained significant association with FC(β±SE,0.06±0.02,P=0.003).CONCLUSION Study results support experimental data of MGP immunomodulatory IBD effect and indicate potential involvement in the pathophysiology of the disease,and possibly extraintestinal manifestations. | Darko Brnic Dinko Martinovic Piero Marin Zivkovic Daria Tokic Marino Vilovic Doris Rusic Ivana Tadin Hadjina Christian Libers Sandro Glumac Daniela Supe-Domic Ante Tonkic Josko Bozic | 2020 | World Journal of Gastroenterology2020，26，32： | 5 |
| 4 | Role of endoscopic ultrasound in anticancer therapy:Current evidence and future perspectives显示文摘The digestive system is one of the most common sites of malignancies in humans.Since gastrointestinal tumors represent a massive global health burden both in terms of morbidity and health care expenditures,scientists continuously develop novel diagnostic and therapeutic methods to ameliorate the detrimental effects of this group of diseases.Apart from the well-established role of the endoscopic ultrasound(EUS)in the diagnostic course of gastrointestinal and hepatobiliary malignancies,we have recently become acquainted with a vast array of its therapeutic possibilities.A multitude of previously established,evidence-based methods that might now be guided by the EUS emerged:Radiofrequency ablation,brachytherapy,fine needle injection,celiac plexus neurolysis,and endoscopic submucosal dissection.In this review we endeavored to provide a comprehensive overview of the role of these methods in different malignancies of the digestive system,primarily in the treatment and symptom control in pancreatic cancer,and additionally in the management of hepatic,gastrointestinal tumors,and pancreatic cysts. | Andre Bratanic Dorotea Bozic Antonio Mestrovic Dinko Martinovic Marko Kumric Tina Ticinovic Kurir Josko Bozic | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 2 |
| 5 | Responses of forest herbs to available undemtory light measured with henrispherical photographs in silver fir-beech forest in Croatia显示文摘 | Oleg Antonic MaRio Bozic | 2006 | Ecological modelline2006，194，： | 1 |
| 6 | Integrative analysis of gene ex-pression patterns predicts specific modulations of defined cell functions by estrogen and tamoxifen in MCF7 breast cancer cells 显示文摘 | Gadal F Starzec A Bozic C | 2005 | J Mol Endocrinol2005，34，2： | 1 |
| 7 | Dynamical mechani- cal analysis of photocrosslinked hyperbranched urethane acrylates 显示文摘 | D2UNUZOVI(~ E S TASIC S V BOZIC B R | 2004 | Journal of the Serbian Chemical Society2004，69，6： | 1 |
| 8 | The influence of SiC particles on the compressive properties of metal matrix composites显示文摘 | BOZIC D MITKOV M | 2001 | Materials Characterization2001，47，： | 1 |
| 9 | Advanced oxidation processes in azo dye wastewater treatment显示文摘 | Papic S Koprivanac N Ana Loncaric Bozic | 2006 | Water Env Res2006，78，6： | 1 |
| 10 | The Potential of Fe-excb :nged Y Zeolite as a Heterogeneous Fenton-type Catalyst for Oxidative Degradation of Reactive Dye in Water显示文摘 | Aleksic M Koprivanac N Bozic A | 2010 | Chemical and Biochemical Engineering Quarterly2010，24，3： | 1 |
| 11 | Repeat 2 - stage revision for recurrent infection of total hip arlhroplasty 显示文摘 | Kalra KP Lin KK Bozic K J | 2010 | J Arthroplasty2010，25，： | 1 |
| 12 | Optimum loading for maximizing muscle power output:the effect of training history显示文摘 | PAZIN N BOZIC P BOSANA | | 0，，9： | 1 |
| 13 | Prevalence and Early Detection of Abdominal Aortic Aneurysm in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma显示文摘 | Jasmina Djordjevic-Jocic Predrag Jovanovic Marija Bozic Aleksandar Tasic Zoran Rancic | 2012 | Current Eye Research2012，，7： | 1 |
| 14 | Does Aspirin Have a Role in Venous Thromboembolism Prophylaxis in Total Knee Arthroplasty Patients?显示文摘 | Kevin J. Bozic Thomas P. Vail Penelope S. Pekow Judith H. Maselli Peter K. Lindenauer Andrew D. Auerbach | 2010 | The Journal of Arthroplasty2010，，7： | 1 |
| 15 | Trends in total knee arthroplasty implantutilization显示文摘 | Nguyen L Lehil MS Bozic KJ | 2015 | Journal of Arthroplasty2015，30，5： | 1 |
| 16 | Pro- perties of copper matrix reinforced with nano-and micro- sized A12 03 particles显示文摘 | Viseslava Rajkovic Dusan Bozic Milan T Jovanovic | 2008 | J Alloys Compd2008，459，： | 1 |
| 17 | Synthesis of new hyper-branched urethane-acrylates and their evaluation in UVcurable coatings 显示文摘 | Tasic S D Bozic B Dunjic B | 2004 | Progress in Organic Coatings2004，51，4： | 1 |
| 18 | Porous tantalum patellar augnentation:the importance of residual bone stock显示文摘 | Ries MD Cabalo A Bozic KJ | | 0，，： | 1 |
| 19 | Effect of bone morphogenetic protein-7 on gene expression of bone morphogenetic protein-4, dentin matrix protein-1, insμLin-like growth factor-I and-II in cementoblasts in vitro 显示文摘 | Bozic D Grgurevic L Erjavec I | 2012 | Collegium antropologicum2012，36，4： | 1 |
| 20 | Distant metastasis occurs late during the genetic evolution of pancreatic cancer显示文摘 | Yachida S Jones S Bozic I | 2010 | Nature2010，467，7319： | 1 |
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