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| 1 | Current status and prospects of clinical proteomics studies on detection of colorectal cancer:Hopes and fears显示文摘Colorectal adenocarcinoma (CRC) is the third most com-mon type of cancer and the fourth most frequent cause of death due to cancer worldwide. Given the natural history of CRC, early diagnosis appears to be the most appropriate tool to reduce disease-related mortality. A fi eld of recent interest is clinical proteomics, which was reported to lead to high sensitivity and specifi cities for early detection of several solid tumors. This emerging fi eld uses mass spectrometry-based protein profi les/pat-terns of easy accessible body fluids to distinguish cancer from non-cancer patients. These discrepancies may be a result of: (1) proteins being abnormally produced or shed and added to the serum proteome, (2) proteins clipped or modified as a consequence of the disease process, or (3) proteins subtracted from the proteome owing to disease-related proteolytic degradation path-ways. Therefore, protein pattern diagnostics would pro-vide easy and reliable tools for detection of cancer. This paper focuses on the current status of clinical proteomics research in oncology and in colorectal cancer especially, and will re? ect on pitfalls and fears in this relatively new area of clinical medicine, which are reproducibility issues and pre-analytical factors, statistical issues, and identifi -cation and nature of discriminating proteins/peptides. | ME de Noo RAEM Tollenaar AM Deelder LH Bouwman | 2006 | World Journal of Gastroenterology2006，12，41： | 3 |
| 2 | Chicken TLR21 is an innate cpg DNA receptor distinct from mammalian TLR9显示文摘 | Keestra AM de Zoete MR Bouwman LI and 1 other | | 0，，01： | 1 |
| 3 | Specificity and sensitivity of transcranial sonography of the substantia nigra in the diagnosis of Parkinson's disease:prospective cohort study in 196 patients显示文摘 | Bouwmans AE Vlaar AM Mess WH | 2013 | BMJ Open2013，，： | 1 |
| 4 | Specificity and sensitivity of transcranial sonography of the substantia nigra in the diagnosis of Parkinson's disease: prospective cohort study in 196 patients显示文摘 | Bouwmans AE Vlaar AM Mess WH | 2013 | BMJ Open2013，3，00： | 1 |
| 5 | Predicting ongoing pregnancy chances after IVF and ICSI : a national prospective study 显示文摘 | Lintsen AM Eijkemans MJ Hunauh CC Bouwmans CA | 2007 | Hum Reprod2007，22，9： | 1 |
| 6 | Transcranial duplex in the differential diagnosis of parkinsonian syndromes:a systematic review显示文摘 | Vlaar AM Bouwmans A Mess WH | | 0，，04： | 1 |
| 7 | Transcranial sonography for the discrimination of idiopathic Parkinsor' s disease from the atypical parkinsonian syndromes显示文摘 | Bouwmans AE Vlaar AM Srulijes K | 2010 | Int Rev Neurobiol2010，90，1： | 1 |
| 8 | The effect of vessel material on granules produced in a high-shear mixer显示文摘 | BOUWMAN AM VISSER MR EISSENS AC | 2004 | Eur J Pharm Sci2004，23，2： | 1 |
| 9 | The relation between granule size,granule stickiness,and torque in the highshear granulation process显示文摘 | BOUWMAN AM HENSTRA MJ HEGGE JJ | 2005 | Pharm Res2005，22，2： | 1 |
| 10 | The relation between granule size,granule stickiness,and torque in the high-shear granulation process显示文摘 | BOUWMAN AM HENSTRA MJ HEGGE JJ | 2005 | Pharm Res2005，22，2： | 1 |
| 11 | The effect of the amount of binder liquid on the granulation mechanisms and structure of microcrystalline cellulose granules prepared by high shear granulation显示文摘 | BOUWMAN AM HENSTRA MJ WESTERMAN D | 2005 | Int J Pharm2005，290，12： | 1 |
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