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| 1 | Current status and prospects of clinical proteomics studies on detection of colorectal cancer:Hopes and fears显示文摘Colorectal adenocarcinoma (CRC) is the third most com-mon type of cancer and the fourth most frequent cause of death due to cancer worldwide. Given the natural history of CRC, early diagnosis appears to be the most appropriate tool to reduce disease-related mortality. A fi eld of recent interest is clinical proteomics, which was reported to lead to high sensitivity and specifi cities for early detection of several solid tumors. This emerging fi eld uses mass spectrometry-based protein profi les/pat-terns of easy accessible body fluids to distinguish cancer from non-cancer patients. These discrepancies may be a result of: (1) proteins being abnormally produced or shed and added to the serum proteome, (2) proteins clipped or modified as a consequence of the disease process, or (3) proteins subtracted from the proteome owing to disease-related proteolytic degradation path-ways. Therefore, protein pattern diagnostics would pro-vide easy and reliable tools for detection of cancer. This paper focuses on the current status of clinical proteomics research in oncology and in colorectal cancer especially, and will re? ect on pitfalls and fears in this relatively new area of clinical medicine, which are reproducibility issues and pre-analytical factors, statistical issues, and identifi -cation and nature of discriminating proteins/peptides. | ME de Noo RAEM Tollenaar AM Deelder LH Bouwman | 2006 | World Journal of Gastroenterology2006，12，41： | 3 |
| 2 | Sensitive determi- nation of circulating anodic antigen in Schistosoma mansoni infect- ed individuals by an enzyme- linked immunosorbent assay using monoclonal antibodies 显示文摘 | Deelder AM De Jonge N Boerman OC | 1989 | Am J Trop Med Hyg1989，40，40： | 1 |
| 3 | Proteomic analysis of uveal melanoma re- veals novel potential markers involved in tumor progression 显示文摘 | Zuidervaart W Hensbergen P J Wong MC Deelder AM Tensen CP Jager MJ | 2006 | Invest Ophthalmol Vis Sei2006，47，3： | 1 |
| 4 | Protein glyeosylation analysis by liquid chromatography-mass spectrometry显示文摘 | Wuhrer M Deelder AM Hokke CH | 2005 | J Chromatogr B Analyt Technol Biomed Life Sei2005，825，2： | 1 |
| 5 | Circulating anodic antigen levels in serum before and after chemotherapy with praziquantel in schistosomiasis mansoni 显示文摘 | Deelder AM De Jonge N Fillie YE | 1989 | Trans Roy Soc Trop Med Hyg1989，83，： | 1 |
| 6 | Quantitative determination of circulating antigens in human schistosomiasis mansoni using an indirect hemagglutination assay 显示文摘 | Deelder AM De Jonge N Fillie YE | 1989 | Am J Trop Med Hyg1989，40，： | 1 |
| 7 | Annexin A2phosphorylation mediates cell scattering and branching morphogenesis via cofilin activa-tion显示文摘 | de Graauw M Tijdens I Smeets MB Hensbergen PJ Deelder AM van de Water B | 2008 | Mol Cell Biol2008，28，3： | 1 |
| 8 | Schistosoma mansoni: Characterization of two circulatingpolysaccharide antigens and the immunological response to these antigens in mouse, hamsterand human infections显示文摘 | Deelder AM Kornells D Van Marck EAE | 1980 | Exp1980，50，： | 1 |
| 9 | Quantitative determination of circulating antigens in humanschistosomiasis mansoni using an indirect hemagglution assay显示文摘 | Deelder AM | 1989 | Am J Trop Med Hyg,1989，40，： | 1 |
| 10 | Protein glycosylation analysis by liquid chromatography-mass spectrometry显示文摘 | Wuhrer M Deelder AM Hokke CH | 2005 | J Chroma-togr B2005，825，2： | 1 |
| 11 | Schistosoma mansoni:characterization of two circulating polysaccharide antigens and the immunological response to these antigens in mouse,hamster and human infections显示文摘 | Deelder AM Kornells D Van Marck EAE | 1980 | Exp Parasitol1980，50，1： | 1 |
| 12 | Quantitative determination of circulating antigens in human schistosomiasis mansoni using an indirect hemagglutination assay显示文摘 | Deelder AM De Jonge N Fiuie YE | 1989 | Am J Trop Med Hyg1989，40，1： | 1 |
| 13 | Oligosaccharide analysis by graphitized carbon liquid chromatography-mass spectrometry显示文摘 | Ruhaak LR Deelder AM Wuhrer M | 2009 | Anal Bioanal Chem2009，394，1： | 1 |
| 14 | Schistosome glycoconjugates in hostparasite interplay显示文摘 | Hokke CH Deelder AM | 2001 | Glycoconj J2001，18，8： | 1 |
| 15 | Elevated proliferation and interleukin-4 release from CD4t cells after chemotherapy in human Schistosoma haematobium infection显示文摘 | Grogan JL Kremsner PG Deelder AM | 1996 | Eur J hnmunol1996，26，： | 1 |
| 16 | Effect of partials postal vein ligation on immune glomerular deposits in schistosoma masoni infected mice显示文摘 | VAN MARK EAE DEELDER AM GIGASE PL | 1997 | Br J Exp Pathol1997，58，： | 1 |
| 17 | Proteomic analysis of uveal melanoma reveals novel potential markers involved in tumor progression显示文摘 | Zuidervaart W Hensbergen PJ Wong MC Deelder AM Tensen CP Jager MJ | 2006 | Invest Ophthalmol Vis Sci2006，47，3： | 1 |
| 18 | Schistosoma: analysis of monoclonal antibodies reactive with the circulating antigens CAA and CCA 显示文摘 | Deelder AM van Dam G J Komelis D | 1996 | Parasitology1996，112，1： | 1 |
| 19 | Elevated prolifer- ation and interleukin-4 release from CD4+ cells after chemothera- py in human Schistosoma haenutobium infection 显示文摘 | Grogan JL Kremsner PG Deelder AM | 1996 | Eur J lm- munol1996，26，6： | 1 |
| 20 | Serum antibody screening by surface plasmon resonance using a natural glycan microarray 显示文摘 | de Boer AR Hokke CH Deelder AM | 2008 | Glycoconjugate J2008，25，1： | 1 |
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