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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Hormonal responses to whole-body vibrationin men 显示文摘 | Bosco C Laeovelli M TsarpelaO | 2000 | European Journal of Applied Physiology2000，81，6： | 1 |
| 3 | The use of vibration as an exerciseintervention显示文摘 | Cardinale M Bosco C | 2003 | Exerc Sport Sci Rev2003，31，1： | 1 |
| 4 | Influence of vibration on mechanical power and electromyogram activity in human arm flexor muscles 显示文摘 | Bosco C Cardinale M Tsarpela O | 1999 | European Journal of Applied Physiology1999，79，4： | 1 |
| 5 | Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immune-related genes and identification of CC-ehemokine ligand 20 as a new hypoxia-inducible gene 显示文摘 | Bosco MC Puppo M Santangelo C | 2006 | J Immunol2006，177，3： | 1 |
| 6 | The influence of whole body vibration on the mechanical behavior of skeletal muscle 显示文摘 | Bosco C Cardinale M Colli R | 1999 | Clinical Physiology1999，19，： | 1 |
| 7 | Effect of organic produc-tion system on broiler carcass and meat quality显示文摘 | Castellini C M ugnai C Dal Bosco A | 2002 | Meat Sci2002，60，3： | 1 |
| 8 | Sequential kidney/islet transplantation:efficacy and safety assessment of a steroid-free immunosuppression protocol显示文摘 | Toso C Baertschiger R Morel P Bosco D Armanet M Wojtusciszyn A | | 0，，： | 1 |
| 9 | Plant growth-promoting Pseudomonas putida WCS358 produces and secretes four cyclic dipeptides: cross-talk with quorum sensing bacterial sensors显示文摘 | Degrassi G Aguilar C Bosco M | 2002 | Current Microbiology2002，45，4： | 1 |
| 10 | Immunohistochemic- al expression of yon Willebrand factor in the preeclamptic placenta 显示文摘 | Parra-Cordero M Bosco C Gonztlez J | 2011 | Journal of Molecular Histology2011，42，5： | 1 |
| 11 | Hormonal responses to whole body vibrations in man 显示文摘 | Bosco C Lacovelli M Tsarpela O | 2000 | Eur J Appl Physiol2000，81，： | 1 |
| 12 | ,Tsapela,O,Influence of vibration on mechanical power and electromyogram activity in human arm flexor muscles显示文摘 | Bosco C Cardinale M | 1999 | European Journal of Applied Physiology1999，79，7： | 1 |
| 13 | Improvement of lipid stability of rabbit meat by vitamin E and C administration显示文摘 | CASTELLINI C BOSCO A BERNARDINI M | 2001 | Journal of the Science of Food and Agricultnre2001，81，1： | 1 |
| 14 | The tryptophan catabolite picolinic acid selectively in- duces the chemokines macrophage inflammatory pro- tein-la and -113 in macrophages显示文摘 | BOSCO M C RAPISARDA A MASSAZZA S | 2000 | The Journal of Im- munology2000，164，： | 1 |
| 15 | Heterozygosis drives maize hybrids to select elite 2,4-diacethylphloroglucinol-producing Pseudomonas strains among resident soil populations显示文摘 | PICARD C BOSCO M | 2006 | FEMS Microbiology Ecology2006，58，： | 1 |
| 16 | Influence of vibration on mechanical power and electromyogram activity in human arm flexor muscles显示文摘 | BOSCO C CARDINALE M TSARPELA O | 1999 | Eur J Appl Physical Occup1999，79，4： | 1 |
| 17 | The cold regular ed genes are involved in the physiological response of barley to cold environment 显示文摘 | Busconi M Bosco C D Crosatt I C | 2001 | Agricultural Science2001，14，： | 1 |
| 18 | The use of vibration as an exercise inter- vention 显示文摘 | CARDINALE M BOSCO C | 2003 | Exerc Sport Sci Rev2003，31，1： | 1 |
| 19 | Hormonal responses to whole-body vibration in men显示文摘 | BOSCO C IACOVELLI M TSARPELA O | 2000 | Eur J Appl Physiol2000，，81： | 1 |
| 20 | Use of progestagen-gonadotrophin treatments in estrus synchronization of sheep 显示文摘 | Boscos C M Samartzi F C Dellis S | 2002 | Theriogenology2002，58，7： | 1 |
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